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Q12550 (XYN4_ASPNG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endo-1,4-beta-xylanase 4

Short name=Xylanase 4
EC=3.2.1.8
Alternative name(s):
1,4-beta-D-xylan xylanohydrolase 4
Gene names
Name:XYN4
OrganismAspergillus niger
Taxonomic identifier5061 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose By similarity. Ref.1

Catalytic activity

Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.

Pathway

Glycan degradation; xylan degradation.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 11 (cellulase G) family.

Biophysicochemical properties

pH dependence:

Optimum pH is 4.0. Ref.1

Temperature dependence:

Optimum temperature is 60 degrees Celsius.

Sequence caution

The sequence AAA99066.1 differs from that shown. Reason: Frameshift at positions 102 and 178.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
Xylan degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processxylan catabolic process

Inferred from direct assay. Source: UniProtKB

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionendo-1,4-beta-xylanase activity

Inferred from direct assay. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 211195Endo-1,4-beta-xylanase 4
PRO_0000393171

Regions

Compositional bias86 – 927Poly-Ser

Sites

Active site1061Nucleophile By similarity
Active site1971Proton donor By similarity

Amino acid modifications

Glycosylation1011N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q12550 [UniParc].

Last modified March 23, 2010. Version 2.
Checksum: B27B7D7F692979EE

FASTA21122,669
        10         20         30         40         50         60 
MKVTAAFAGL LVTAFAPPVP EPVLVSRSAG INYVQNYNGN LGDFTYDESA GTFSMYWEDG 

        70         80         90        100        110        120 
VSSDFVVGLG WTTGSSNAIT YSAEYSASGS SSYLAVYGWV NLSQAEYYIV EDYGDYNPCS 

       130        140        150        160        170        180 
SATSLGTEYS DGSTYQVCTD TRTNEPSITG TSTFTQYFSV RESTRTSGTV TVAIHFNFWA 

       190        200        210 
QHGFGNSDFN YQVMAVEAWS GACSASVTIS S 

« Hide

References

[1]"Cloning of two beta-xylanase-encoding genes from Aspergillus niger and their expression in Saccharomyces cerevisiae."
Luttig M., Pretorius I.S., van Zyl W.H.
Biotechnol. Lett. 19:411-415(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
Strain: ATCC 90196 / Alo MP-22.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U39785 mRNA. Translation: AAA99066.1. Frameshift.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH11. Glycoside Hydrolase Family 11.
mycoCLAPXYN11D_ASPNG.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG05353.

Enzyme and pathway databases

UniPathwayUPA00114.

Family and domain databases

Gene3D2.60.120.180. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR001137. Glyco_hydro_11.
IPR013319. Glyco_hydro_11/12.
IPR018208. Glyco_hydro_11_AS.
[Graphical view]
PfamPF00457. Glyco_hydro_11. 1 hit.
[Graphical view]
PRINTSPR00911. GLHYDRLASE11.
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00776. GLYCOSYL_HYDROL_F11_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXYN4_ASPNG
AccessionPrimary (citable) accession number: Q12550
Entry history
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: February 19, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries