Reviewed, UniProtKB/Swiss-Prot Q12548 (SODC_ASPJA)

Names and origin

Protein names

Recommended name:
    Superoxide dismutase [Cu-Zn]
    EC=1.15.1.1

Gene names

Name:

sodC

Organism

Aspergillus japonicus

Taxonomic identifier

34381 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	120 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	antioxidant activity Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 120	›120	Superoxide dismutase [Cu-Zn]		PRO_0000164109
Sites
	Metal binding	11	1	Copper By similarity
	Metal binding	13	1	Copper By similarity
	Metal binding	28	1	Copper By similarity
	Metal binding	28	1	Zinc By similarity
	Metal binding	36	1	Zinc By similarity
	Metal binding	45	1	Zinc By similarity
	Metal binding	48	1	Zinc By similarity
	Metal binding	85	1	Copper By similarity
Amino acid modifications
	Disulfide bond	22 ↔ 112		By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q12548-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: CB91C4E276F4741E	FASTA	120	12,122
	10 20 30 40 50 60 NSSSVPLHGF HVHALGDTTN GCMSTGPHFN PTGKEHGAPQ DENRHAGDLG NITAGADGVA 70 80 90 100 110 120 NVNVSDSQIP LTGAHSIIGR AVVVHADPDD LGKGGHELSK TTGNSNSSMD SCAHGIQGIL

References

[1]	"Cloning and characterization of a copper/zinc-superoxide dismutase gene from Aspergillus japonicus." Lin C.T., Lin M.T., Sheu D.C., Duan K.J. Taiwania 39:73-79(1994) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	L32834 Genomic DNA. Translation: AAA87597.1.
3D structure databases
HSSP	HSSP built from PDB template 1OZU based on UniProtKB P00441.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.15.1.1. 15246.
Family and domain databases
InterPro	IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn. [Graphical view]
Gene3D	G3DSA:2.60.40.200. SOD_Cu_Zn. 1 hit.
PANTHER	PTHR10003. SOD_Cu_Zn. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
PRINTS	PR00068. CUZNDISMTASE.
ProDom	PD000469. SOD_CU_ZN. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00087. SOD_CU_ZN_1. 1 hit. PS00332. SOD_CU_ZN_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODC_ASPJA

Accession

Primary (citable) accession number: Q12548

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)