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Protein

Acid phosphatase

Gene

aphA

Organism
Aspergillus ficuum
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Cu cationCurated

Enzyme regulationi

Competitively inhibited by phosphomycin and inorganic orthophosphate.

pH dependencei

Optimum pH is 6. Inactive above pH 6.7.

Temperature dependencei

Optimum temperature is 63 degrees Celsius.

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandCopper

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase (EC:3.1.3.2)
Alternative name(s):
APase6
pH 6-optimum acid phosphatase
Gene namesi
Name:aphA
OrganismiAspergillus ficuum
Taxonomic identifieri5058 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 222 PublicationsAdd BLAST22
ChainiPRO_000002399723 – 605Acid phosphataseAdd BLAST583
PropeptideiPRO_0000023998606 – 6149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi352N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi429N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi512N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi559N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi578N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated; probably with N-linked high-mannose oligosaccharides.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliQ12546
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 176Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST97

Keywords - Domaini

Signal

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.380, 1 hit
InterProiView protein in InterPro
IPR014390 Acid_Pase_Asper
IPR004843 Calcineurin-like_PHP_ApaH
IPR003961 FN3_dom
IPR008963 Purple_acid_Pase-like_N
IPR015914 Purple_acid_Pase_N
IPR025733 Purple_acid_PPase_C_dom
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF14008 Metallophos_C, 1 hit
PF16656 Pur_ac_phosph_N, 1 hit
PIRSFiPIRSF000900 Acid_Ptase_Asper, 1 hit
SUPFAMiSSF49363 SSF49363, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGTAASALL VALSATAAQA RPVVDERFPY TGPAVPIGDW VDPTINGNGK
60 70 80 90 100
GFPRLVEPPA VKPATANPRN NVNVISLSYI PKGMHIHYQT PFGLGQLPAV
110 120 130 140 150
RWGKDPRNLN STAQGYSHTY DRTPSCSQVK AVTQCSQFFH EVSIDGLEPD
160 170 180 190 200
TTYYYQIPAA NGTTQSEVLS FKTSRPAGHP GSFSVAVLND MGYTNAHGTH
210 220 230 240 250
KQLVKAATEG TAFAWHGGDL SYADDWYSGI LACADDWPVC YNGTSSTLPG
260 270 280 290 300
GGPLPEEYKK PLPAGEIPDQ GGPQGGDMSV LYESNWDLWQ QWLNNVTLKI
310 320 330 340 350
PYMVLPGNHE ASCAEFDGPH NILTAYLNDD IANGTAPTDN LTYYSCPPSQ
360 370 380 390 400
RNFTAYQHRF RMPGPETGGV GNFWYSFDYG LAHFVSIDGE TDFANSPEWN
410 420 430 440 450
FAEDVTGNET LPSESETFIT DSGPFGNVNG SVHETKSYEQ WHWLQQDLAK
460 470 480 490 500
VDRSKTPWVI VMSHRPMYSS AYSSYQLHVR EAFEGLLLKY GVDAYLSGHI
510 520 530 540 550
HWYERLYPLG ANGTIDTAAI VNNNTYYAHN GKSITHIING MAGNIESHSE
560 570 580 590 600
FSDGEGLTNI TALLDKVHYG FSKLTIFNET ALKWELIRGD DGTVGDSLTL
610
LKPSHVAGGK KLHS
Length:614
Mass (Da):67,211
Last modified:November 1, 1996 - v1
Checksum:i7016738F63C62EBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18553 Genomic DNA Translation: AAA91632.1
PIRiJC2545

Similar proteinsi

Entry informationi

Entry nameiPPA_ASPFI
AccessioniPrimary (citable) accession number: Q12546
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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