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Protein

Laccase-2

Gene

lcc2

Organism
Agaricus bisporus (White button mushroom)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82Copper 1; type 2By similarity1
Metal bindingi84Copper 2; type 3By similarity1
Metal bindingi127Copper 2; type 3By similarity1
Metal bindingi129Copper 3; type 3By similarity1
Metal bindingi417Copper 4; type 1By similarity1
Metal bindingi420Copper 1; type 2By similarity1
Metal bindingi422Copper 3; type 3By similarity1
Metal bindingi470Copper 3; type 3By similarity1
Metal bindingi471Copper 4; type 1By similarity1
Metal bindingi472Copper 2; type 3By similarity1
Metal bindingi476Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Protein family/group databases

CAZyiAA1. Auxiliary Activities 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-2 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 2
Diphenol oxidase 2
Laccase II
Urishiol oxidase 2
Gene namesi
Name:lcc2
OrganismiAgaricus bisporus (White button mushroom)
Taxonomic identifieri5341 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000000291920 – 520Laccase-2Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi454N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi492N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ12542.
SMRiQ12542.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 145Plastocyanin-like 1Add BLAST125
Domaini157 – 305Plastocyanin-like 2Add BLAST149
Domaini375 – 488Plastocyanin-like 3Add BLAST114

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiView protein in InterPro
IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
PfamiView protein in Pfam
PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiView protein in PROSITE
PS00079. MULTICOPPER_OXIDASE1. 2 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFSNAFVLV AACISSVLAD TKTFNFDLVN TRLAPDGFER DTVVINGEFP
60 70 80 90 100
GTLVQVNKGD SVRIPVNNKL TSSTMRRSVS IHWHGFFQAR TSGQDGPAFV
110 120 130 140 150
NQCPQPPNTT FTYEFSVADE SGTFWYHSHL STQYCDGLRG AFVVYDPEDP
160 170 180 190 200
LGHLYDVDDE TTVITLAEWY HVLAPDINNE FFSSGIIPVQ DSGLINGKGR
210 220 230 240 250
FNGGPETPFA VVNVEQGKRY RFRVIAISCR PFFTFSVDNH NLTFMEADSV
260 270 280 290 300
EHDPVEIQNV DIYAAQRVSV ILNANQPVDN YWMRAPMTGG NPDRNPNLNI
310 320 330 340 350
SLTLAILRYK GAPEVEPTTV NVPGHKLLDQ EMHPIAQEGP GKLGDGPPDK
360 370 380 390 400
HITLNIAQPN APFFDINGIS YISPTVPVLL QILSGAKRPE DVLPSEQIFF
410 420 430 440 450
VPKNSLIEVN IPGEGAHPFH LHGHNFDVVL ASNDDTFNFV NPPRRDVYPI
460 470 480 490 500
NGGNTTFRFF TDNPGAWFLH CHIDWHLEAG LAIVFAEAPE DNVSGPQSQI
510 520
TPQDWLDLCP EYNAIEPEFQ
Length:520
Mass (Da):57,823
Last modified:November 1, 1996 - v1
Checksum:iEF100145F0A697AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10663 mRNA. Translation: AAA17035.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10663 mRNA. Translation: AAA17035.1.

3D structure databases

ProteinModelPortaliQ12542.
SMRiQ12542.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiAA1. Auxiliary Activities 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiView protein in InterPro
IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
PfamiView protein in Pfam
PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiView protein in PROSITE
PS00079. MULTICOPPER_OXIDASE1. 2 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLAC2_AGABI
AccessioniPrimary (citable) accession number: Q12542
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 10, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.