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Reviewed, UniProtKB/Swiss-Prot Q12541 (LAC1_AGABI)

Last modified November 25, 2008. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Laccase-1
    EC=1.10.3.2
Alternative name(s):
    Laccase I
    Benzenediol:oxygen oxidoreductase 1
    Urishiol oxidase 1
    Diphenol oxidase 1
Gene names
Name: lcc1
OrganismAgaricus bisporus (Common mushroom)
Taxonomic identifier5341 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Homobasidiomycetes › Agaricomycetidae › Agaricales › Agaricaceae › Agaricus

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Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activity

4 benzenediol + O(2) = 4 benzosemiquinone + 2 H(2)O.

Cofactor

Binds 4 copper ions per monomer By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the multicopper oxidase family.

Contains 3 plastocyanin-like domains.

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Ontologies

Keywords

   Biological processLignin degradation
   Cellular componentSecreted
   DomainRepeat
Signal
   LigandCopper
Metal-binding
   Molecular functionOxidoreductase
   PTMGlycoprotein
   Technical termDirect protein sequencing

Gene Ontology (GO)

   Biological processlignin catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncopper ion binding

Inferred from electronic annotation. Source: InterPro

laccase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 520501Laccase-1
PRO_0000002918

Regions

Domain21 – 145125Plastocyanin-like 1
Domain157 – 305149Plastocyanin-like 2
Domain375 – 488114Plastocyanin-like 3

Sites

Metal binding821Copper 1; type 2 By similarity
Metal binding841Copper 2; type 3 By similarity
Metal binding1271Copper 2; type 3 By similarity
Metal binding1291Copper 3; type 3 By similarity
Metal binding4171Copper 4; type 1 By similarity
Metal binding4201Copper 1; type 2 By similarity
Metal binding4221Copper 3; type 3 By similarity
Metal binding4701Copper 3; type 3 By similarity
Metal binding4711Copper 4; type 1 By similarity
Metal binding4721Copper 2; type 3 By similarity
Metal binding4761Copper 4; type 1 By similarity

Amino acid modifications

Glycosylation1081N-linked (GlcNAc...) Potential
Glycosylation2391N-linked (GlcNAc...) Potential
Glycosylation2991N-linked (GlcNAc...) Potential
Glycosylation4541N-linked (GlcNAc...) Potential
Glycosylation4921N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q12541-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 943DB3F23297B891

FASTA52058,099
        10         20         30         40         50         60 
MRLSNALVLV AACISSVVAK TRTFDFDLVN TRLAPDGFER DTVVINGEFP GTLIQVNKGD 

        70         80         90        100        110        120 
SVRIPLHNKL TSPTMRRSVS IHWHGFFQAR TSGQDGPSFV NQCPQPPNTT FTYEFSVAEQ 

       130        140        150        160        170        180 
SGTFWYHSHL STQYCDGLRG AFIVYDPRDP LRHLYDVDDE STVITLAEWY HILAPDATNE 

       190        200        210        220        230        240 
FFSSGIIPVQ DSGLINGKGR FNGGPLTPFA VVNVRRGKRY RLRVIAISCR PFFTFSVDNH 

       250        260        270        280        290        300 
SLVFMEADGV EHDPVEVQNV DIYAAQRVSV ILHANQPIDN YWIRAPMTGG NPDRNPNLNI 

       310        320        330        340        350        360 
SLTLAILRYH GARHVEPTTV NVPGHKLLDQ EMHPIRQEGP GKLGDGPPDK HITLNIAQPN 

       370        380        390        400        410        420 
APFFDINGIS YISPTVPVLL QILSGAKRPE DVLPSEQIFF VPKNSLIEVN IPGEGAHPFH 

       430        440        450        460        470        480 
LHGHNFDVVL ASNDDTFNFK NPPRRDVYPI NGGNTTFRFF TDNPGAWFLH CHIDWHLEAG 

       490        500        510        520 
LAIVFAEAPE DNVSGPQSQI TPQDWLDLCP EYNAIEPEFQ

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References

[1]"Identification of two laccase genes in the cultivated mushroom Agaricus bisporus."
Perry C.R., Smith M., Britnell C.H., Wood D.A., Thurston C.F.
J. Gen. Microbiol. 139:1209-1218(1993) [PubMed: 8360614] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
Strain: D649.
Tissue: Mycelium.

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Cross-references

Sequence databases

L10664 Genomic DNA. Translation: AAC18877.1.

3D structure databases

HSSPHSSP built from PDB template 1HFU based on UniProtKB Q9Y780.
ModBaseSearch...

Family and domain databases

InterProIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
Gene3DG3DSA:2.60.40.420. Cupredoxin. 3 hits.
PfamPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
PROSITEPS00079. MULTICOPPER_OXIDASE1. 2 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLAC1_AGABI
AccessionPrimary (citable) accession number: Q12541
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 25, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents