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Q12541

- LAC1_AGABI

UniProt

Q12541 - LAC1_AGABI

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Protein
Laccase-1
Gene
lcc1
Organism
Agaricus bisporus (White button mushroom)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi82 – 821Copper 1; type 2 By similarity
Metal bindingi84 – 841Copper 2; type 3 By similarity
Metal bindingi127 – 1271Copper 2; type 3 By similarity
Metal bindingi129 – 1291Copper 3; type 3 By similarity
Metal bindingi417 – 4171Copper 4; type 1 By similarity
Metal bindingi420 – 4201Copper 1; type 2 By similarity
Metal bindingi422 – 4221Copper 3; type 3 By similarity
Metal bindingi470 – 4701Copper 3; type 3 By similarity
Metal bindingi471 – 4711Copper 4; type 1 By similarity
Metal bindingi472 – 4721Copper 2; type 3 By similarity
Metal bindingi476 – 4761Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-1 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 1
Diphenol oxidase 1
Laccase I
Urishiol oxidase 1
Gene namesi
Name:lcc1
OrganismiAgaricus bisporus (White button mushroom)
Taxonomic identifieri5341 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919
Add
BLAST
Chaini20 – 520501Laccase-1
PRO_0000002918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi108 – 1081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi299 – 2991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi454 – 4541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi492 – 4921N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ12541.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 145125Plastocyanin-like 1
Add
BLAST
Domaini157 – 305149Plastocyanin-like 2
Add
BLAST
Domaini375 – 488114Plastocyanin-like 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 2 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12541-1 [UniParc]FASTAAdd to Basket

« Hide

MRLSNALVLV AACISSVVAK TRTFDFDLVN TRLAPDGFER DTVVINGEFP    50
GTLIQVNKGD SVRIPLHNKL TSPTMRRSVS IHWHGFFQAR TSGQDGPSFV 100
NQCPQPPNTT FTYEFSVAEQ SGTFWYHSHL STQYCDGLRG AFIVYDPRDP 150
LRHLYDVDDE STVITLAEWY HILAPDATNE FFSSGIIPVQ DSGLINGKGR 200
FNGGPLTPFA VVNVRRGKRY RLRVIAISCR PFFTFSVDNH SLVFMEADGV 250
EHDPVEVQNV DIYAAQRVSV ILHANQPIDN YWIRAPMTGG NPDRNPNLNI 300
SLTLAILRYH GARHVEPTTV NVPGHKLLDQ EMHPIRQEGP GKLGDGPPDK 350
HITLNIAQPN APFFDINGIS YISPTVPVLL QILSGAKRPE DVLPSEQIFF 400
VPKNSLIEVN IPGEGAHPFH LHGHNFDVVL ASNDDTFNFK NPPRRDVYPI 450
NGGNTTFRFF TDNPGAWFLH CHIDWHLEAG LAIVFAEAPE DNVSGPQSQI 500
TPQDWLDLCP EYNAIEPEFQ 520
Length:520
Mass (Da):58,099
Last modified:November 1, 1996 - v1
Checksum:i943DB3F23297B891
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10664 Genomic DNA. Translation: AAC18877.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10664 Genomic DNA. Translation: AAC18877.1 .

3D structure databases

ProteinModelPortali Q12541.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 2 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of two laccase genes in the cultivated mushroom Agaricus bisporus."
    Perry C.R., Smith M., Britnell C.H., Wood D.A., Thurston C.F.
    J. Gen. Microbiol. 139:1209-1218(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    Strain: D649.
    Tissue: Mycelium.

Entry informationi

Entry nameiLAC1_AGABI
AccessioniPrimary (citable) accession number: Q12541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi