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Protein

Laccase-1

Gene

lcc1

Organism
Agaricus bisporus (White button mushroom)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82Copper 1; type 2By similarity1
Metal bindingi84Copper 2; type 3By similarity1
Metal bindingi127Copper 2; type 3By similarity1
Metal bindingi129Copper 3; type 3By similarity1
Metal bindingi417Copper 4; type 1By similarity1
Metal bindingi420Copper 1; type 2By similarity1
Metal bindingi422Copper 3; type 3By similarity1
Metal bindingi470Copper 3; type 3By similarity1
Metal bindingi471Copper 4; type 1By similarity1
Metal bindingi472Copper 2; type 3By similarity1
Metal bindingi476Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Protein family/group databases

CAZyiAA1. Auxiliary Activities 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-1 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 1
Diphenol oxidase 1
Laccase I
Urishiol oxidase 1
Gene namesi
Name:lcc1
OrganismiAgaricus bisporus (White button mushroom)
Taxonomic identifieri5341 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesAgaricaceaeAgaricus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000000291820 – 520Laccase-1Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Glycosylationi454N-linked (GlcNAc...)Sequence analysis1
Glycosylationi492N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ12541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 145Plastocyanin-like 1Add BLAST125
Domaini157 – 305Plastocyanin-like 2Add BLAST149
Domaini375 – 488Plastocyanin-like 3Add BLAST114

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 2 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSNALVLV AACISSVVAK TRTFDFDLVN TRLAPDGFER DTVVINGEFP
60 70 80 90 100
GTLIQVNKGD SVRIPLHNKL TSPTMRRSVS IHWHGFFQAR TSGQDGPSFV
110 120 130 140 150
NQCPQPPNTT FTYEFSVAEQ SGTFWYHSHL STQYCDGLRG AFIVYDPRDP
160 170 180 190 200
LRHLYDVDDE STVITLAEWY HILAPDATNE FFSSGIIPVQ DSGLINGKGR
210 220 230 240 250
FNGGPLTPFA VVNVRRGKRY RLRVIAISCR PFFTFSVDNH SLVFMEADGV
260 270 280 290 300
EHDPVEVQNV DIYAAQRVSV ILHANQPIDN YWIRAPMTGG NPDRNPNLNI
310 320 330 340 350
SLTLAILRYH GARHVEPTTV NVPGHKLLDQ EMHPIRQEGP GKLGDGPPDK
360 370 380 390 400
HITLNIAQPN APFFDINGIS YISPTVPVLL QILSGAKRPE DVLPSEQIFF
410 420 430 440 450
VPKNSLIEVN IPGEGAHPFH LHGHNFDVVL ASNDDTFNFK NPPRRDVYPI
460 470 480 490 500
NGGNTTFRFF TDNPGAWFLH CHIDWHLEAG LAIVFAEAPE DNVSGPQSQI
510 520
TPQDWLDLCP EYNAIEPEFQ
Length:520
Mass (Da):58,099
Last modified:November 1, 1996 - v1
Checksum:i943DB3F23297B891
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10664 Genomic DNA. Translation: AAC18877.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10664 Genomic DNA. Translation: AAC18877.1.

3D structure databases

ProteinModelPortaliQ12541.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiAA1. Auxiliary Activities 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 2 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC1_AGABI
AccessioniPrimary (citable) accession number: Q12541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.