Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribonuclease MRP protein subunit RMP1

Gene

RMP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as part of ribonuclease MRP (RNase MRP), which is involved in rRNA processing in mitochondria.1 Publication

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • rRNA primary transcript binding Source: SGD

GO - Biological processi

  • maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay Source: SGD

Keywordsi

Biological processrRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-32282-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease MRP protein subunit RMP1
Alternative name(s):
RNA-processing protein RMP1
RNase MRP 23.6 kDa subunit
Gene namesi
Name:RMP1Imported
Ordered Locus Names:YLR145W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR145W
SGDiS000004135 RMP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei86 – 108HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi103C → R in RMP1-6; temperature-sensitive phenotype. Defective in 5.8S rRNA processing. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002705721 – 201Ribonuclease MRP protein subunit RMP1Add BLAST201

Proteomic databases

MaxQBiQ12530
PaxDbiQ12530
PRIDEiQ12530

Interactioni

Subunit structurei

Component of RNase MRP complex which consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RPP1P387862EBI-29955,EBI-15968

Protein-protein interaction databases

BioGridi31414, 179 interactors
DIPiDIP-4813N
IntActiQ12530, 11 interactors
MINTiQ12530
STRINGi4932.YLR145W

Structurei

3D structure databases

ProteinModelPortaliQ12530
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi183 – 193Poly-LysSequence analysisAdd BLAST11

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000066119
InParanoidiQ12530
KOiK14532
OMAiQFVTLGV
OrthoDBiEOG092C4V3O

Sequencei

Sequence statusi: Complete.

Q12530-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEMDNVIRS LEQEYRLILL LNHRNKNQHR AASWYGSFNE MKRNCGQIIT
60 70 80 90 100
LFSSRRLQAK RLKDVEWVKL HRLLQRALFR QLKRWYWQFN GVIALGQFVT
110 120 130 140 150
LGCTLVTLLA NVRALYMRLW EINETEFIRC GCLIKNLPRT KAKSVVNDVE
160 170 180 190 200
ELGEIIDEDI GNNVQENELV ITSIPKPLTE NCKKKKKRKK KNKSAIDGIF

G
Length:201
Mass (Da):23,619
Last modified:November 1, 1996 - v1
Checksum:iEDE608D76402BBBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53879 Genomic DNA Translation: AAB82379.1
Z73317 Genomic DNA Translation: CAA97717.1
BK006945 Genomic DNA Translation: DAA09455.1
PIRiS64994
RefSeqiNP_013246.1, NM_001182032.1

Genome annotation databases

EnsemblFungiiYLR145W; YLR145W; YLR145W
GeneIDi850837
KEGGisce:YLR145W

Similar proteinsi

Entry informationi

Entry nameiRMP1_YEAST
AccessioniPrimary (citable) accession number: Q12530
Secondary accession number(s): D6VYD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health