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Q12530 (RMP1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease MRP protein subunit RMP1
Alternative name(s):
RNA-processing protein RMP1
RNase MRP 23.6 kDa subunit
Gene names
Name:RMP1
Ordered Locus Names:YLR145W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as part of ribonuclease MRP (RNase MRP), which is involved in rRNA processing in mitochondria. Ref.5

Subunit structure

Component of RNase MRP complex which consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex. Ref.5

Subcellular location

Membrane; Single-pass membrane protein Potential. Cytoplasm. Nucleus Ref.3.

Miscellaneous

Present with 556 molecules/cell in log phase SD medium. Ref.4

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Ribonuclease MRP protein subunit RMP1
PRO_0000270572

Regions

Transmembrane86 – 10823Helical; Potential
Compositional bias183 – 19311Poly-Lys

Experimental info

Mutagenesis1031C → R in RMP1-6; temperature-sensitive phenotype. Defective in 5.8S rRNA processing. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q12530 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: EDE608D76402BBBC

FASTA20123,619
        10         20         30         40         50         60 
MDEMDNVIRS LEQEYRLILL LNHRNKNQHR AASWYGSFNE MKRNCGQIIT LFSSRRLQAK 

        70         80         90        100        110        120 
RLKDVEWVKL HRLLQRALFR QLKRWYWQFN GVIALGQFVT LGCTLVTLLA NVRALYMRLW 

       130        140        150        160        170        180 
EINETEFIRC GCLIKNLPRT KAKSVVNDVE ELGEIIDEDI GNNVQENELV ITSIPKPLTE 

       190        200 
NCKKKKKRKK KNKSAIDGIF G 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component."
Salinas K., Wierzbicki S., Zhou L., Schmitt M.E.
J. Biol. Chem. 280:11352-11360(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE RNASE MRP COMPLEX BY MASS SPECTROMETRY, MUTAGENESIS OF CYS-103.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U53879 Genomic DNA. Translation: AAB82379.1.
Z73317 Genomic DNA. Translation: CAA97717.1.
BK006945 Genomic DNA. Translation: DAA09455.1.
PIRS64994.
RefSeqNP_013246.1. NM_001182032.1.

3D structure databases

ProteinModelPortalQ12530.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31414. 116 interactions.
DIPDIP-4813N.
IntActQ12530. 9 interactions.
MINTMINT-573400.
STRING4932.YLR145W.

Proteomic databases

MaxQBQ12530.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR145W; YLR145W; YLR145W.
GeneID850837.
KEGGsce:YLR145W.

Organism-specific databases

CYGDYLR145w.
SGDS000004135. RMP1.

Phylogenomic databases

eggNOGNOG42290.
HOGENOMHOG000066119.
KOK14532.
OMAINETEFI.
OrthoDBEOG7T4MXW.

Enzyme and pathway databases

BioCycYEAST:G3O-32282-MONOMER.

Gene expression databases

GenevestigatorQ12530.

Family and domain databases

ProtoNetSearch...

Other

NextBio967114.

Entry information

Entry nameRMP1_YEAST
AccessionPrimary (citable) accession number: Q12530
Secondary accession number(s): D6VYD9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD