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Q12530

- RMP1_YEAST

UniProt

Q12530 - RMP1_YEAST

Protein

Ribonuclease MRP protein subunit RMP1

Gene

RMP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Functions as part of ribonuclease MRP (RNase MRP), which is involved in rRNA processing in mitochondria.1 Publication

    GO - Molecular functioni

    1. rRNA primary transcript binding Source: SGD

    GO - Biological processi

    1. maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
    2. mRNA cleavage Source: SGD

    Keywords - Biological processi

    rRNA processing

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32282-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease MRP protein subunit RMP1
    Alternative name(s):
    RNA-processing protein RMP1
    RNase MRP 23.6 kDa subunit
    Gene namesi
    Name:RMP1Imported
    Ordered Locus Names:YLR145W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLR145w.
    SGDiS000004135. RMP1.

    Subcellular locationi

    Membrane Sequence Analysis; Single-pass membrane protein Sequence Analysis. Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. nucleus Source: UniProtKB-SubCell
    4. ribonuclease MRP complex Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi103 – 1031C → R in RMP1-6; temperature-sensitive phenotype. Defective in 5.8S rRNA processing. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201Ribonuclease MRP protein subunit RMP1PRO_0000270572Add
    BLAST

    Proteomic databases

    MaxQBiQ12530.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12530.

    Interactioni

    Subunit structurei

    Component of RNase MRP complex which consists of an RNA moiety and at least 10 protein subunits including POP1, POP3, POP4, POP5, POP6, POP7, POP8, RMP1, RPP1 and SNM1, many of which are shared with the RNase P complex.1 Publication

    Protein-protein interaction databases

    BioGridi31414. 116 interactions.
    DIPiDIP-4813N.
    IntActiQ12530. 9 interactions.
    MINTiMINT-573400.
    STRINGi4932.YLR145W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12530.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei86 – 10823HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi183 – 19311Poly-LysSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42290.
    HOGENOMiHOG000066119.
    KOiK14532.
    OMAiINETEFI.
    OrthoDBiEOG7T4MXW.

    Sequencei

    Sequence statusi: Complete.

    Q12530-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEMDNVIRS LEQEYRLILL LNHRNKNQHR AASWYGSFNE MKRNCGQIIT    50
    LFSSRRLQAK RLKDVEWVKL HRLLQRALFR QLKRWYWQFN GVIALGQFVT 100
    LGCTLVTLLA NVRALYMRLW EINETEFIRC GCLIKNLPRT KAKSVVNDVE 150
    ELGEIIDEDI GNNVQENELV ITSIPKPLTE NCKKKKKRKK KNKSAIDGIF 200
    G 201
    Length:201
    Mass (Da):23,619
    Last modified:November 1, 1996 - v1
    Checksum:iEDE608D76402BBBC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53879 Genomic DNA. Translation: AAB82379.1.
    Z73317 Genomic DNA. Translation: CAA97717.1.
    BK006945 Genomic DNA. Translation: DAA09455.1.
    PIRiS64994.
    RefSeqiNP_013246.1. NM_001182032.1.

    Genome annotation databases

    EnsemblFungiiYLR145W; YLR145W; YLR145W.
    GeneIDi850837.
    KEGGisce:YLR145W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U53879 Genomic DNA. Translation: AAB82379.1 .
    Z73317 Genomic DNA. Translation: CAA97717.1 .
    BK006945 Genomic DNA. Translation: DAA09455.1 .
    PIRi S64994.
    RefSeqi NP_013246.1. NM_001182032.1.

    3D structure databases

    ProteinModelPortali Q12530.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31414. 116 interactions.
    DIPi DIP-4813N.
    IntActi Q12530. 9 interactions.
    MINTi MINT-573400.
    STRINGi 4932.YLR145W.

    Proteomic databases

    MaxQBi Q12530.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR145W ; YLR145W ; YLR145W .
    GeneIDi 850837.
    KEGGi sce:YLR145W.

    Organism-specific databases

    CYGDi YLR145w.
    SGDi S000004135. RMP1.

    Phylogenomic databases

    eggNOGi NOG42290.
    HOGENOMi HOG000066119.
    KOi K14532.
    OMAi INETEFI.
    OrthoDBi EOG7T4MXW.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32282-MONOMER.

    Miscellaneous databases

    NextBioi 967114.

    Gene expression databases

    Genevestigatori Q12530.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component."
      Salinas K., Wierzbicki S., Zhou L., Schmitt M.E.
      J. Biol. Chem. 280:11352-11360(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE RNASE MRP COMPLEX BY MASS SPECTROMETRY, MUTAGENESIS OF CYS-103.

    Entry informationi

    Entry nameiRMP1_YEAST
    AccessioniPrimary (citable) accession number: Q12530
    Secondary accession number(s): D6VYD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 556 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3