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Reviewed, UniProtKB/Swiss-Prot Q12527 (ATG11_YEAST)

Last modified June 16, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Autophagy-related protein 11
Alternative name(s):
    Cytoplasm to vacuole targeting protein 9
Gene names
Name: ATG11
Synonyms: CVT9
Ordered Locus Names: YPR049C
ORF Names: YP9499.07c
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length1178 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in cytoplasm to vacuole transport (Cvt) and pexophagy. Recruites the ATG19-prAPE1 complex to the pre-autophagosome, the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion. Ref.2 Ref.3 Ref.4 Ref.5

Subunit structure

Homodimer and potential homooligomers. Interacts with ATG1 kinase and the ATG19 cargo protein transporter. Ref.3 Ref.5

Subcellular location

Membrane; Peripheral membrane protein. Note: Punctate structures. Ref.4 Ref.7

Miscellaneous

Present with 86 molecules/cell in log phase SD medium. Ref.8

Sequence similarities

Belongs to the ATG11 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself1EBI-31977,EBI-31977
ATG1P531041EBI-31977,EBI-2657

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11781178Autophagy-related protein 11
PRO_0000124554

Regions

Coiled coil538 – 57235 Potential
Coiled coil696 – 850155 Potential
Compositional bias598 – 61013Asn-rich
Compositional bias1050 – 109950Ser-rich

Amino acid modifications

Modified residue6131Phosphoserine Ref.9
Modified residue9351Phosphoserine Ref.9

Sequences

Sequence LengthMass (Da)Tools
Q12527-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A904B92E9AE79449

FASTA1,178135,025
        10         20         30         40         50         60 
MADADEYSTA PTQQEITPLQ TTATIINAIS GECITTNVDF FVSLDKFKQF IARKWKIPPD 

        70         80         90        100        110        120 
QLLILLPYGN KLKPSMFKEL LINRSFTLND FYVYDRRLFS LVSKPTPTNL LTSKDSNPMN 

       130        140        150        160        170        180 
SPNSNDLTET LEYLIKNSHI SQYQGSDTIM IKPMPSPLED ADVDLSRLNY HSVTSLLTTN 

       190        200        210        220        230        240 
LGWLSALEID VHYFKSLIPD IIAHIKRIFD GLTVCSQYLK LYCFDVESLY NSNVQFLNQL 

       250        260        270        280        290        300 
VDNGMTSKWE KCFNDTLSKL TALEGDSLQK FINIESLLEN EKSVKILNHS INGKLNKIKR 

       310        320        330        340        350        360 
EIDENASFRD IITVNIDRLR QMFTPNESKF ELEDQMAESF EVLVSEMRTR SRNVLDKEEE 

       370        380        390        400        410        420 
EFNSQEFLKS MNVMLEKDKK ESVKTLFTIS QALYSQIGEL IDLKKSLQKH AVAILGNIAF 

       430        440        450        460        470        480 
TQMEILGIKR LLLNECNKDL ELYKKYEVEF AQVEDLPLIY GLYLIEKYRR LSWFQQILSF 

       490        500        510        520        530        540 
ISNFNQDLEL FKQNELRTRN KWVKNFGSIA TVFCEDLLSS SDFKRLNEYH SHTSPPNEDE 

       550        560        570        580        590        600 
EDENENSIAN YRQDLVKVSQ AIDNYMTQIK ETDVSEPIID LLSKTLFETK RFHIIYSNFK 

       610        620        630        640        650        660 
NNNNNSSNGN SISPEGSIAL KSDDVVKGYK TRIKKLESLL HEFQYSDIGH WPQGVLNTHL 

       670        680        690        700        710        720 
KPFRGSATSI NKKKFLGASV LLEPANISEV NIDSVSQANN HQIQELESNV DDLLHQLQLL 

       730        740        750        760        770        780 
KEENNRKSMQ ISEMGKKISD LEVEKTAYRE TLTNLNQELA RLTNEEQSHR TEIFTLNASF 

       790        800        810        820        830        840 
KKQLNDIISQ DNEKIEKLTG DYDDVSKSRE RLQMDLDESN KKHEQEVNLL KADIERLGKQ 

       850        860        870        880        890        900 
IVTSEKSYAE TNSSSMEKGE KFETIPLAED PGRENQISAY TQTLQDRIFD IISTNIFILE 

       910        920        930        940        950        960 
NIGLLLTFDN NNNIQIRRVK GLKKGTAQSN ILDESTQMLD AHDNSLIKSP VFQKLKDEYE 

       970        980        990       1000       1010       1020 
LIKSVANGSE KDTQQSIFLG NITQLYDNKL YEVAVIRRFK DIETLAKKLT KENKIKRTLL 

      1030       1040       1050       1060       1070       1080 
ERFQREKVTL RNFQIGDLAL FLPTRENVNS VGSMSSSTSS LSSSFSSVDL STPPPLDAMS 

      1090       1100       1110       1120       1130       1140 
IQSSPSVIHS NVINQASISG RDKNKLMRPW AAFTAFEEST RYFLKDEKGL TKGKEWFVGR 

      1150       1160       1170 
IVTLEHFVAD SPSNNPFRLP KGSVWFQVTA VVVSYQGV 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed: 9169875] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway."
Harding T.M., Hefner-Gravink A., Thumm M., Klionsky D.J.
J. Biol. Chem. 271:17621-17624(1996) [PubMed: 8663607] [Abstract]
Cited for: FUNCTION.
[3]"Tor-mediated induction of autophagy via an Apg1 protein kinase complex."
Kamada Y., Funakoshi T., Shintani T., Nagano K., Ohsumi M., Ohsumi Y.
J. Cell Biol. 150:1507-1513(2000) [PubMed: 10995454] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ATG1.
[4]"Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole."
Kim J., Kamada Y., Stromhaug P.E., Guan J., Hefner-Gravink A., Baba M., Scott S.V., Ohsumi Y., Dunn W.A. Jr., Klionsky D.J.
J. Cell Biol. 153:381-396(2001) [PubMed: 11309418] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[5]"Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway."
Shintani T., Huang W.-P., Stromhaug P.E., Klionsky D.J.
Dev. Cell 3:825-837(2002) [PubMed: 12479808] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ATG19.
[6]"A unified nomenclature for yeast autophagy-related genes."
Klionsky D.J., Cregg J.M., Dunn W.A. Jr., Emr S.D., Sakai Y., Sandoval I.V., Sibirny A., Subramani S., Thumm M., Veenhuis M., Ohsumi Y.
Dev. Cell 5:539-545(2003) [PubMed: 14536056] [Abstract]
Cited for: NOMENCLATURE.
[7]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613 AND SER-935, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

Z71255 Genomic DNA. Translation: CAA94996.1.
Z49219 Genomic DNA. Translation: CAA89169.1.
PIRS54073.
RefSeqNP_015374.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:1492N.
IntActQ12527. 16 interactions.

Proteomic databases

PRIDEQ12527.

Genome annotation databases

EnsemblYPR049C. Saccharomyces cerevisiae. [Contig view]
GeneID856162.
GenomeReviewsGene locus YPR049C in contig U00094_GR.
KEGGsce:YPR049C.
NMPDRfig|4932.3.peg.6510.

Organism-specific databases

CYGDYPR049c.
SGDS000006253. ATG11.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMQ12527.
OMAQ12527. YGLYLIE.

Gene expression databases

ArrayExpressQ12527.
GermOnlineYPR049C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR019460. Autophagy-rel_prot_11.
[Graphical view]
PfamPF10377. ATG11. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio981307.

Entry information

Entry nameATG11_YEAST
AccessionPrimary (citable) accession number: Q12527
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents