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Protein

Ras-like protein

Gene

rasA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi62 – 66GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: AspGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • conidium formation Source: AspGD
  • regulation of conidium formation Source: AspGD
  • signal transduction Source: InterPro
  • spore germination Source: AspGD

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein
Gene namesi
Name:rasA
ORF Names:AN0182
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826751 – 209Ras-like proteinAdd BLAST209
PropeptideiPRO_0000281330210 – 212Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi205S-palmitoyl cysteineBy similarity1
Lipidationi206S-palmitoyl cysteineBy similarity1
Modified residuei209Cysteine methyl esterBy similarity1
Lipidationi209S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PRIDEiQ12526

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00002552

Structurei

3D structure databases

ProteinModelPortaliQ12526
SMRiQ12526
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

HOGENOMiHOG000233973
InParanoidiQ12526
KOiK07827
OMAiYAQTYKL
OrthoDBiEOG092C4VY0

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKFLREYK LVVVGGGGVG KSCLTIQLIQ SHFVDEYDPT IEDSYRKQCV
60 70 80 90 100
IDDEVALLDV LDTAGQEEYS AMREQYMRTG EGFLLVYSIT SRQSFEEIMT
110 120 130 140 150
FQQQILRVKD KDYFPIIVVG NKCDLDKERV VSEQEGESLA RQFGCKFIET
160 170 180 190 200
SAKSRINVEN AFYDLVREIR RYNKEMSNPS GSGAFGARAP DSKMDVSEPG
210
ESAGCCGKCI VM
Length:212
Mass (Da):23,845
Last modified:May 1, 2007 - v2
Checksum:i073FC2F09BB6D15E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188 – 189RA → PR in AAA20964 (PubMed:8035812).Curated2
Sequence conflicti188 – 189RA → PR in AAA20965 (PubMed:8035812).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03025 Genomic DNA Translation: AAA20965.1
U03023 mRNA Translation: AAA20964.1
AACD01000005 Genomic DNA Translation: EAA66055.1
BN001308 Genomic DNA Translation: CBF90024.1
PIRiA53778
RefSeqiXP_657786.1, XM_652694.1

Genome annotation databases

EnsemblFungiiCADANIAT00002552; CADANIAP00002552; CADANIAG00002552
EAA66055; EAA66055; AN0182.2
GeneIDi2875958
KEGGiani:AN0182.2

Similar proteinsi

Entry informationi

Entry nameiRAS_EMENI
AccessioniPrimary (citable) accession number: Q12526
Secondary accession number(s): C8VUY1, Q5BGZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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