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Protein

Ras-like protein

Gene

rasA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTPBy similarity
Nucleotide bindingi62 – 665GTPBy similarity
Nucleotide bindingi121 – 1244GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: ASPGD
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • conidium formation Source: ASPGD
  • regulation of conidium formation Source: ASPGD
  • small GTPase mediated signal transduction Source: InterPro
  • spore germination Source: ASPGD
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein
Gene namesi
Name:rasA
ORF Names:AN0182
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome VIII
  • UP000005890 Componenti: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:AN0182.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Ras-like proteinPRO_0000082675Add
BLAST
Propeptidei210 – 2123Removed in mature formBy similarityPRO_0000281330

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi205 – 2051S-palmitoyl cysteineBy similarity
Lipidationi206 – 2061S-palmitoyl cysteineBy similarity
Modified residuei209 – 2091Cysteine methyl esterBy similarity
Lipidationi209 – 2091S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Structurei

3D structure databases

ProteinModelPortaliQ12526.
SMRiQ12526. Positions 6-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

HOGENOMiHOG000233973.
InParanoidiQ12526.
KOiK07827.
OMAiRRYNREM.
OrthoDBiEOG7H1JXN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKFLREYK LVVVGGGGVG KSCLTIQLIQ SHFVDEYDPT IEDSYRKQCV
60 70 80 90 100
IDDEVALLDV LDTAGQEEYS AMREQYMRTG EGFLLVYSIT SRQSFEEIMT
110 120 130 140 150
FQQQILRVKD KDYFPIIVVG NKCDLDKERV VSEQEGESLA RQFGCKFIET
160 170 180 190 200
SAKSRINVEN AFYDLVREIR RYNKEMSNPS GSGAFGARAP DSKMDVSEPG
210
ESAGCCGKCI VM
Length:212
Mass (Da):23,845
Last modified:May 1, 2007 - v2
Checksum:i073FC2F09BB6D15E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1892RA → PR in AAA20964 (PubMed:8035812).Curated
Sequence conflicti188 – 1892RA → PR in AAA20965 (PubMed:8035812).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03025 Genomic DNA. Translation: AAA20965.1.
U03023 mRNA. Translation: AAA20964.1.
AACD01000005 Genomic DNA. Translation: EAA66055.1.
BN001308 Genomic DNA. Translation: CBF90024.1.
PIRiA53778.
RefSeqiXP_657786.1. XM_652694.1.

Genome annotation databases

EnsemblFungiiCADANIAT00002552; CADANIAP00002552; CADANIAG00002552.
EAA66055; EAA66055; AN0182.2.
GeneIDi2875958.
KEGGiani:AN0182.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03025 Genomic DNA. Translation: AAA20965.1.
U03023 mRNA. Translation: AAA20964.1.
AACD01000005 Genomic DNA. Translation: EAA66055.1.
BN001308 Genomic DNA. Translation: CBF90024.1.
PIRiA53778.
RefSeqiXP_657786.1. XM_652694.1.

3D structure databases

ProteinModelPortaliQ12526.
SMRiQ12526. Positions 6-172.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANIAT00002552; CADANIAP00002552; CADANIAG00002552.
EAA66055; EAA66055; AN0182.2.
GeneIDi2875958.
KEGGiani:AN0182.2.

Organism-specific databases

EuPathDBiFungiDB:AN0182.

Phylogenomic databases

HOGENOMiHOG000233973.
InParanoidiQ12526.
KOiK07827.
OMAiRRYNREM.
OrthoDBiEOG7H1JXN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Developmental decisions in Aspergillus nidulans are modulated by Ras activity."
    Som T., Kolaparthi V.S.R.
    Mol. Cell. Biol. 14:5333-5348(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiRAS_EMENI
AccessioniPrimary (citable) accession number: Q12526
Secondary accession number(s): C8VUY1, Q5BGZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 2007
Last modified: May 11, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.