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Protein

WD repeat-containing protein YPL247C

Gene

YPL247C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-34133-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein YPL247C
Gene namesi
Ordered Locus Names:YPL247C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL247C.
SGDiS000006168. YPL247C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523WD repeat-containing protein YPL247CPRO_0000242490Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471PhosphoserineCombined sources
Modified residuei65 – 651PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12523.
PeptideAtlasiQ12523.
PRIDEiQ12523.

PTM databases

iPTMnetiQ12523.

Interactioni

Protein-protein interaction databases

BioGridi35916. 8 interactions.
DIPiDIP-6366N.
IntActiQ12523. 6 interactions.
MINTiMINT-685692.

Structurei

3D structure databases

ProteinModelPortaliQ12523.
SMRiQ12523. Positions 226-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati173 – 21341WD 1Add
BLAST
Repeati241 – 28141WD 2Add
BLAST
Repeati285 – 32541WD 3Add
BLAST
Repeati392 – 43241WD 4Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat WDR68 family.Curated
Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000006939.
HOGENOMiHOG000260968.
InParanoidiQ12523.
KOiK11805.
OMAiMYSPLDF.
OrthoDBiEOG7K9KD0.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12523-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPFHNGNKR SSISFGSSQR QPYNKNNYLS GTNGPSSAAQ DQGRGPSPFG
60 70 80 90 100
MSGNTTNGGN SKRNSGCDLS ATYYASRSPM YSPLDFSPPV FSPNHSQLQQ
110 120 130 140 150
ARGYAANIPV VSNLMNPSMA SVCEYQSHYP LFGLDWSADD YVCLGSYKED
160 170 180 190 200
SRNKLQVLHS NDLLSWESVV DADVVYPVSK IQWVPSQLYP RKLATCSDSL
210 220 230 240 250
RIWSVSPEER QFQEQINLSL CKYNRQHPAN PAAADDMKVI GTFPPITSFD
260 270 280 290 300
WNTVDTNLII SSSIDTTCIV WDLQSSHYVK TQLIAHDSEV FDVRFLTKST
310 320 330 340 350
QLFASCGGDG SVRVFDLRSL AHSTIIYEPP SSSVSGATAG TITPSSKGSD
360 370 380 390 400
ALLRLEPSPY DPNVLATFAA DSNKIIILDM RNPESPILNL QGHGSSVNGI
410 420 430 440 450
KWHPTKRNVL LSCGDDCQVL YWDLNSSFME INAAGSKSPS IHGTSLEDPD
460 470 480 490 500
GDTEMTDGGA GSGLNEDPLS LNNNSKQVCK TLETPNMMYA NKTQEINNIA
510 520
WRPQRGDWFG CVSGKKFQNV RVL
Length:523
Mass (Da):57,324
Last modified:November 1, 1996 - v1
Checksum:i02CE191AB77E712C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67751 Genomic DNA. Translation: CAA91597.1.
Z73603 Genomic DNA. Translation: CAA97968.1.
BK006949 Genomic DNA. Translation: DAA11190.1.
PIRiS61017.
RefSeqiNP_015077.1. NM_001184061.1.

Genome annotation databases

EnsemblFungiiYPL247C; YPL247C; YPL247C.
GeneIDi855829.
KEGGisce:YPL247C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67751 Genomic DNA. Translation: CAA91597.1.
Z73603 Genomic DNA. Translation: CAA97968.1.
BK006949 Genomic DNA. Translation: DAA11190.1.
PIRiS61017.
RefSeqiNP_015077.1. NM_001184061.1.

3D structure databases

ProteinModelPortaliQ12523.
SMRiQ12523. Positions 226-450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35916. 8 interactions.
DIPiDIP-6366N.
IntActiQ12523. 6 interactions.
MINTiMINT-685692.

PTM databases

iPTMnetiQ12523.

Proteomic databases

MaxQBiQ12523.
PeptideAtlasiQ12523.
PRIDEiQ12523.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL247C; YPL247C; YPL247C.
GeneIDi855829.
KEGGisce:YPL247C.

Organism-specific databases

EuPathDBiFungiDB:YPL247C.
SGDiS000006168. YPL247C.

Phylogenomic databases

GeneTreeiENSGT00390000006939.
HOGENOMiHOG000260968.
InParanoidiQ12523.
KOiK11805.
OMAiMYSPLDF.
OrthoDBiEOG7K9KD0.

Enzyme and pathway databases

BioCyciYEAST:G3O-34133-MONOMER.

Miscellaneous databases

PROiQ12523.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-47 AND SER-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYP247_YEAST
AccessioniPrimary (citable) accession number: Q12523
Secondary accession number(s): D6W3C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 799 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.