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Protein

UDP-galactose transporter homolog 1

Gene

HUT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen. Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum. Overexpression confers resistance to the immunosuppressive drug, leflunomide.3 Publications

GO - Molecular functioni

  • UDP-galactose transmembrane transporter activity Source: SGD

GO - Biological processi

  • UDP-galactose transmembrane transport Source: GO_Central
  • UDP-galactose transport Source: SGD
  • UDP-glucose transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34130-MONOMER.
ReactomeiR-SCE-174362. Transport and synthesis of PAPS.
R-SCE-727802. Transport of nucleotide sugars.

Protein family/group databases

TCDBi2.A.7.11.6. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-galactose transporter homolog 1
Alternative name(s):
Multicopy suppressor of leflunomide-sensitivity protein 6
Gene namesi
Name:HUT1
Synonyms:MLF6
Ordered Locus Names:YPL244C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL244C.
SGDiS000006165. HUT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44LumenalSequence analysis
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Topological domaini26 – 4217CytoplasmicSequence analysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence analysisAdd
BLAST
Topological domaini64 – 10643LumenalSequence analysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence analysisAdd
BLAST
Topological domaini128 – 1369CytoplasmicSequence analysis
Transmembranei137 – 15721HelicalSequence analysisAdd
BLAST
Topological domaini158 – 17417LumenalSequence analysisAdd
BLAST
Transmembranei175 – 19218HelicalSequence analysisAdd
BLAST
Topological domaini193 – 21422CytoplasmicSequence analysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence analysisAdd
BLAST
Topological domaini236 – 24510LumenalSequence analysis
Transmembranei246 – 26621HelicalSequence analysisAdd
BLAST
Topological domaini267 – 28014CytoplasmicSequence analysisAdd
BLAST
Transmembranei281 – 30323HelicalSequence analysisAdd
BLAST
Topological domaini304 – 3074LumenalSequence analysis
Transmembranei308 – 32720HelicalSequence analysisAdd
BLAST
Topological domaini328 – 33912CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339UDP-galactose transporter homolog 1PRO_0000213414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ12520.

Interactioni

Protein-protein interaction databases

BioGridi35919. 23 interactions.
DIPiDIP-3958N.
IntActiQ12520. 1 interaction.
MINTiMINT-475283.

Structurei

3D structure databases

ProteinModelPortaliQ12520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063090.
HOGENOMiHOG000091197.
InParanoidiQ12520.
KOiK15275.
OMAiMEAHGAG.
OrthoDBiEOG092C4IT1.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSTSSLVI CAIGIYATFL TWALVQEPLA TRTWPNSMGK FQFPNVISLI
60 70 80 90 100
QASVAMMMGY LYLNWKKVEY PPRKMIKDHW KQLMLISFTQ SSSGPLATTS
110 120 130 140 150
LKHVDYLTYM LAKSCKMIPV LLVHLLLYRT PIASQKKVVA LLVSLGVTIF
160 170 180 190 200
TIGGNDGKKL KRSFNESGND NKLQGFGLLF SSLFLDGLTN ATQDKLLKAN
210 220 230 240 250
KAKEKGKQTL ITGAHLMFTL NLFVILWNIL YFIVIDCKQW DNAVSVLTMD
260 270 280 290 300
PQVWGYLMLY SFCGAMGQCF IFYTLEQFGS LVLIMITVTR KMVSMILSII
310 320 330
VFGKSVRFQQ WVGMFIVFGG ITWEALNKKK ANIPKAKSA
Length:339
Mass (Da):38,075
Last modified:November 1, 1996 - v1
Checksum:i1094A9D705BD3563
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67751 Genomic DNA. Translation: CAA91600.1.
Z73600 Genomic DNA. Translation: CAA97965.1.
AY692836 Genomic DNA. Translation: AAT92855.1.
BK006949 Genomic DNA. Translation: DAA11193.1.
PIRiS61020.
RefSeqiNP_015080.1. NM_001184058.1.

Genome annotation databases

EnsemblFungiiYPL244C; YPL244C; YPL244C.
GeneIDi855832.
KEGGisce:YPL244C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67751 Genomic DNA. Translation: CAA91600.1.
Z73600 Genomic DNA. Translation: CAA97965.1.
AY692836 Genomic DNA. Translation: AAT92855.1.
BK006949 Genomic DNA. Translation: DAA11193.1.
PIRiS61020.
RefSeqiNP_015080.1. NM_001184058.1.

3D structure databases

ProteinModelPortaliQ12520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35919. 23 interactions.
DIPiDIP-3958N.
IntActiQ12520. 1 interaction.
MINTiMINT-475283.

Protein family/group databases

TCDBi2.A.7.11.6. the drug/metabolite transporter (dmt) superfamily.

Proteomic databases

PRIDEiQ12520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL244C; YPL244C; YPL244C.
GeneIDi855832.
KEGGisce:YPL244C.

Organism-specific databases

EuPathDBiFungiDB:YPL244C.
SGDiS000006165. HUT1.

Phylogenomic databases

GeneTreeiENSGT00530000063090.
HOGENOMiHOG000091197.
InParanoidiQ12520.
KOiK15275.
OMAiMEAHGAG.
OrthoDBiEOG092C4IT1.

Enzyme and pathway databases

BioCyciYEAST:G3O-34130-MONOMER.
ReactomeiR-SCE-174362. Transport and synthesis of PAPS.
R-SCE-727802. Transport of nucleotide sugars.

Miscellaneous databases

PROiQ12520.

Family and domain databases

InterProiIPR013657. UAA.
[Graphical view]
PfamiPF08449. UAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHUT1_YEAST
AccessioniPrimary (citable) accession number: Q12520
Secondary accession number(s): D6W3C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.