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Protein

DNA damage-binding protein CMR1

Gene

CMR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA in vitro (PubMed:22367945). May be involved in DNA-metabolic processes (PubMed:23349438).1 Publication1 Publication

Miscellaneous

Present with 3810 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • DNA binding Source: SGD

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB-KW
  • regulation of DNA damage checkpoint Source: SGD

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage

Enzyme and pathway databases

BioCyciYEAST:G3O-29551-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA damage-binding protein CMR11 Publication
Alternative name(s):
Changed mutation rate protein 11 Publication
Gene namesi
Name:CMR11 Publication
Ordered Locus Names:YDL156WImported
ORF Names:D1536
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL156W.
SGDiS000002315. CMR1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408741 – 522DNA damage-binding protein CMR1Add BLAST522

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineCombined sources1
Modified residuei69PhosphothreonineCombined sources1
Modified residuei224PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12510.
PRIDEiQ12510.

PTM databases

iPTMnetiQ12510.

Expressioni

Inductioni

Closely coexpressed with replication factor A (RF-A), the cohesion complex and the DNA polymerases alpha, delta and epsilon.1 Publication

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31907. 695 interactors.
DIPiDIP-1004N.
IntActiQ12510. 28 interactors.
MINTiMINT-560906.
STRINGi4932.YDL156W.

Structurei

3D structure databases

ProteinModelPortaliQ12510.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati183 – 224WD 1Sequence analysisAdd BLAST42
Repeati239 – 281WD 2Sequence analysisAdd BLAST43
Repeati287 – 327WD 3Sequence analysisAdd BLAST41
Repeati331 – 371WD 4Sequence analysisAdd BLAST41
Repeati388 – 427WD 5Sequence analysisAdd BLAST40
Repeati442 – 481WD 6Sequence analysisAdd BLAST40
Repeati482 – 521WD 7Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the WD repeat DDB2/WDR76 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00510000048144.
HOGENOMiHOG000234710.
InParanoidiQ12510.
OMAiGMVISED.
OrthoDBiEOG092C1WXP.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR033052. Cmr1/WDR76.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PANTHERiPTHR14773:SF2. PTHR14773:SF2. 1 hit.
PfamiView protein in Pfam
PF00400. WD40. 1 hit.
SMARTiView protein in SMART
SM00320. WD40. 4 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12510-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPELTEFQKK RLENIKRNND LLKKLHLSGV ASQIKHEAGV LEKSRAPAKK
60 70 80 90 100
KQKTTNTRAT KSASPTLPTR RSRRLRGESA DDVKGIPNVN DNQLLKMGSP
110 120 130 140 150
DGQDKNFIDA IKEKPVIGDV KLSDLIKDED ESALLEKFKR FNNGNFSSGD
160 170 180 190 200
FFEEIKKRQG DVTGMDEFDL DLYDVFQPNE IKITYERISA TYFHPAMEKK
210 220 230 240 250
LIIAGDTSGT VGFWNVRDEP LADSEEDRME EPDITRVKLF TKNVGRIDCF
260 270 280 290 300
PADTSKILLT SYDGSIRSVH LNNLQSEEVL TLKNEYDDSL GISDCQFSYE
310 320 330 340 350
NPNVLFLTTL GGEFTTFDTR VKKSEYNLRR LADKKIGSMA INPMRPYEIA
360 370 380 390 400
TGSLDRTLKI WDTRNLVKKP EWSQYEDYPS HEIVSTYDSR LSVSAVSYSP
410 420 430 440 450
TDGTLVCNGY DDTIRLFDVK SRDHLSAKLE PKLTIQHNCQ TGRWTSILKA
460 470 480 490 500
RFKPNKNVFA IANMKRAIDI YNSEGQQLAH LPTATVPAVI SWHPLRNWIA
510 520
GGNSSGKIFL FTDDSGTIKQ EE
Length:522
Mass (Da):59,156
Last modified:November 1, 1996 - v1
Checksum:i3BE716E4858EF3E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97751 Genomic DNA. Translation: CAA66335.1.
Z74204 Genomic DNA. Translation: CAA98730.1.
BK006938 Genomic DNA. Translation: DAA11704.1.
PIRiS67704.
RefSeqiNP_010125.1. NM_001180216.1.

Genome annotation databases

EnsemblFungiiYDL156W; YDL156W; YDL156W.
GeneIDi851399.
KEGGisce:YDL156W.

Similar proteinsi

Entry informationi

Entry nameiCMR1_YEAST
AccessioniPrimary (citable) accession number: Q12510
Secondary accession number(s): D6VRJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names