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Protein

Actin-like protein ARP6

Gene

ARP6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.3 Publications

GO - Molecular functioni

  • nucleosome binding Source: SGD

GO - Biological processi

  • chromatin remodeling Source: SGD
  • histone exchange Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32236-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein ARP6
Gene namesi
Name:ARP6
Ordered Locus Names:YLR085C
ORF Names:L2393, L9449.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR085C.
SGDiS000004075. ARP6.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • nuclear periphery Source: SGD
  • Swr1 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Actin-like protein ARP6PRO_0000089121Add
BLAST

Proteomic databases

MaxQBiQ12509.

Interactioni

Subunit structurei

Component of the SWR1 chromatin remodeling complex composed of at least ACT1, ARP4, RVB1, RVB2, ARP6, YAF9, VPS71, VPS72, SWC3, SWC4, SWC5, SWC7 and SWR1, and perhaps BDF1.3 Publications

GO - Molecular functioni

  • nucleosome binding Source: SGD

Protein-protein interaction databases

BioGridi31358. 345 interactions.
DIPiDIP-5169N.
IntActiQ12509. 7 interactions.
MINTiMINT-497450.

Structurei

3D structure databases

ProteinModelPortaliQ12509.
SMRiQ12509. Positions 2-424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP6 subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00720000108833.
HOGENOMiHOG000170496.
InParanoidiQ12509.
KOiK11662.
OMAiDFKTTTT.
OrthoDBiEOG092C23I1.

Family and domain databases

InterProiIPR004000. Actin.
IPR030054. Arp6.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 3 hits.
PTHR11937:SF47. PTHR11937:SF47. 3 hits.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12509-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPPIVIDN GSYEIKFGPS TNKKPFRALN ALAKDKFGTS YLSNHIKNIK
60 70 80 90 100
DISSITFRRP HELGQLTLWE LESCIWDYCL FNPSEFDGFD LKEGKGHHLV
110 120 130 140 150
ASESCMTLPE LSKHADQVIF EEYEFDSLFK SPVAVFVPFT KSYKGEMRTI
160 170 180 190 200
SGKDEDIDIV RGNSDSTNST SSESKNAQDS GSDYHDFQLV IDSGFNCTWI
210 220 230 240 250
IPVLKGIPYY KAVKKLDIGG RFLTGLLKET LSFRHYNMMD ETILVNNIKE
260 270 280 290 300
QCLFVSPVSY FDSFKTKDKH ALEYVLPDFQ TSFLGYVRNP RKENVPLPED
310 320 330 340 350
AQIITLTDEL FTIPETFFHP EISQITKPGI VEAILESLSM LPEIVRPLMV
360 370 380 390 400
GNIVCTGGNF NLPNFAQRLA AELQRQLPTD WTCHVSVPEG DCALFGWEVM
410 420 430
SQFAKTDSYR KARVTREEYY EHGPDWCTKH RFGYQNWI
Length:438
Mass (Da):50,044
Last modified:November 1, 1996 - v1
Checksum:i92D201F62D04232B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53880 Genomic DNA. Translation: AAB67589.1.
Z73257 Genomic DNA. Translation: CAA97645.1.
BK006945 Genomic DNA. Translation: DAA09401.1.
PIRiS64917.
RefSeqiNP_013186.1. NM_001181972.1.

Genome annotation databases

EnsemblFungiiYLR085C; YLR085C; YLR085C.
GeneIDi850774.
KEGGisce:YLR085C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53880 Genomic DNA. Translation: AAB67589.1.
Z73257 Genomic DNA. Translation: CAA97645.1.
BK006945 Genomic DNA. Translation: DAA09401.1.
PIRiS64917.
RefSeqiNP_013186.1. NM_001181972.1.

3D structure databases

ProteinModelPortaliQ12509.
SMRiQ12509. Positions 2-424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31358. 345 interactions.
DIPiDIP-5169N.
IntActiQ12509. 7 interactions.
MINTiMINT-497450.

Proteomic databases

MaxQBiQ12509.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR085C; YLR085C; YLR085C.
GeneIDi850774.
KEGGisce:YLR085C.

Organism-specific databases

EuPathDBiFungiDB:YLR085C.
SGDiS000004075. ARP6.

Phylogenomic databases

GeneTreeiENSGT00720000108833.
HOGENOMiHOG000170496.
InParanoidiQ12509.
KOiK11662.
OMAiDFKTTTT.
OrthoDBiEOG092C23I1.

Enzyme and pathway databases

BioCyciYEAST:G3O-32236-MONOMER.

Miscellaneous databases

PROiQ12509.

Family and domain databases

InterProiIPR004000. Actin.
IPR030054. Arp6.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 3 hits.
PTHR11937:SF47. PTHR11937:SF47. 3 hits.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARP6_YEAST
AccessioniPrimary (citable) accession number: Q12509
Secondary accession number(s): D6VY85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 238 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.