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Protein

Late secretory pathway protein AVL9

Gene

AVL9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions in the late secretory pathway. Required for the generation of secretory vesicles as well as for actin polarization and polarized growth.1 Publication

GO - Biological processi

  • post-Golgi vesicle-mediated transport Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32259-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Late secretory pathway protein AVL9
Alternative name(s):
APL2 VPS1 synthetic lethal protein 9
Gene namesi
Name:AVL9
Ordered Locus Names:YLR114C
ORF Names:L2941
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR114C.
SGDiS000004104. AVL9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764Late secretory pathway protein AVL9PRO_0000247424Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei519 – 5191PhosphoserineCombined sources
Modified residuei524 – 5241PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12500.

PTM databases

iPTMnetiQ12500.

Interactioni

Protein-protein interaction databases

BioGridi31386. 121 interactions.
DIPiDIP-4819N.
IntActiQ12500. 1 interaction.
MINTiMINT-482194.

Structurei

3D structure databases

ProteinModelPortaliQ12500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi603 – 68280Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the AVL9 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000010255.
HOGENOMiHOG000001119.
InParanoidiQ12500.
OrthoDBiEOG7VQJNP.

Family and domain databases

InterProiIPR018307. ABL9/DENND6_dom.
[Graphical view]
PfamiPF09794. Avl9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEHEEAVIF GICLVDFHHK RGPEIEYWYG LPEGTQSAEL WPNLPFQALP
60 70 80 90 100
DGSHSFEETF TYFTLLYDER RQRSPPNGAT DLSDDSINDN TTLFAISCSR
110 120 130 140 150
QIKSDELVTK DKDVTRSTVQ KAIVVISRQP IFGQIKDKLS IVTNAFFLQH
160 170 180 190 200
DFGDRKIIQS LYENLKSIYT PASLVRNAEN RLYIGLCLRK ILHDFKRNAL
210 220 230 240 250
VLLKAIMLEK KIIVYGNDVE ALCNLQFGLI SLIPDLMSNL QDSGSPQLFQ
260 270 280 290 300
DISKLNVVDS FKSSNRESVL RFLGFPLPIF EKGGLFSPYT PLQQMNDIRS
310 320 330 340 350
ERTLFFMIGS SNTLLAEQKE ELCHIFVNTD NSTVDILDKT LNPVLQLSSH
360 370 380 390 400
DKKWIESISG IVSDTWNEND DETPKNSQFE GSEDFIRWQF EDYLTGLLSS
410 420 430 440 450
VKLSDYLDLH KENDQALKTI PEDMLNSNPV HLFNLNWVQS WKETQNFLIF
460 470 480 490 500
NSRTDDRLFD LFPPKHIYNG ADTLSLLQQR FLATFHNLKR SSSNSSSNKN
510 520 530 540 550
GHQSEEDIKD QESIESKKSV SQISVNPGKN TDKPAANLWN SWKEYFNKPK
560 570 580 590 600
NTANEDVTES TEDLKNRSKT SNAIQKAMMG LGLHYKPDAE TDQQSEEVGN
610 620 630 640 650
SEDNEDDDTD EDSEDDDDDG GDDDDSEDDD DDDDGEGDEN GDDGEGDENG
660 670 680 690 700
DDGEGDENGD KEDSQDFSNG FTDVTNINTD HDKENEQNFE GNAENFNEDE
710 720 730 740 750
TVADKDIEGG PESNKNSDSK TDIYENDRNV EDSSKTRNTV KKSNEEGGAN
760
DAAIGNCVQD EEKL
Length:764
Mass (Da):86,426
Last modified:November 1, 1996 - v1
Checksum:i159A00CF933A5C4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89514 Genomic DNA. Translation: CAA61692.1.
U53878 Genomic DNA. Translation: AAB67559.1.
Z73286 Genomic DNA. Translation: CAA97681.1.
BK006945 Genomic DNA. Translation: DAA09428.1.
PIRiS64951.
RefSeqiNP_013215.1. NM_001182001.1.

Genome annotation databases

EnsemblFungiiYLR114C; YLR114C; YLR114C.
GeneIDi850805.
KEGGisce:YLR114C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89514 Genomic DNA. Translation: CAA61692.1.
U53878 Genomic DNA. Translation: AAB67559.1.
Z73286 Genomic DNA. Translation: CAA97681.1.
BK006945 Genomic DNA. Translation: DAA09428.1.
PIRiS64951.
RefSeqiNP_013215.1. NM_001182001.1.

3D structure databases

ProteinModelPortaliQ12500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31386. 121 interactions.
DIPiDIP-4819N.
IntActiQ12500. 1 interaction.
MINTiMINT-482194.

PTM databases

iPTMnetiQ12500.

Proteomic databases

MaxQBiQ12500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR114C; YLR114C; YLR114C.
GeneIDi850805.
KEGGisce:YLR114C.

Organism-specific databases

EuPathDBiFungiDB:YLR114C.
SGDiS000004104. AVL9.

Phylogenomic databases

GeneTreeiENSGT00390000010255.
HOGENOMiHOG000001119.
InParanoidiQ12500.
OrthoDBiEOG7VQJNP.

Enzyme and pathway databases

BioCyciYEAST:G3O-32259-MONOMER.

Miscellaneous databases

PROiQ12500.

Family and domain databases

InterProiIPR018307. ABL9/DENND6_dom.
[Graphical view]
PfamiPF09794. Avl9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a 37.6 kbp cosmid clone from the right arm of Saccharomyces cerevisiae chromosome XII, carrying YAP3, HOG1, SNR6, tRNA-Arg3 and 23 new open reading frames, among which several homologies to proteins involved in cell division control and to mammalian growth factors and other animal proteins are found."
    Verhasselt P., Volckaert G.
    Yeast 13:241-250(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 90840 / EAY235 / FY23.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Avl9p, a member of a novel protein superfamily, functions in the late secretory pathway."
    Harsay E., Schekman R.
    Mol. Biol. Cell 18:1203-1219(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-524, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-519, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAVL9_YEAST
AccessioniPrimary (citable) accession number: Q12500
Secondary accession number(s): D6VYB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 7500 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.