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Protein

Late secretory pathway protein AVL9

Gene

AVL9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in the late secretory pathway. Required for the generation of secretory vesicles as well as for actin polarization and polarized growth.1 Publication

Miscellaneous

Present with 7500 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • post-Golgi vesicle-mediated transport Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-32259-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Late secretory pathway protein AVL9
Alternative name(s):
APL2 VPS1 synthetic lethal protein 9
Gene namesi
Name:AVL9
Ordered Locus Names:YLR114C
ORF Names:L2941
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YLR114C
SGDiS000004104 AVL9

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474241 – 764Late secretory pathway protein AVL9Add BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei519PhosphoserineCombined sources1
Modified residuei524PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12500
PaxDbiQ12500
PRIDEiQ12500

PTM databases

CarbonylDBiQ12500
iPTMnetiQ12500

Interactioni

Protein-protein interaction databases

BioGridi31386, 254 interactors
DIPiDIP-4819N
IntActiQ12500, 1 interactor
STRINGi4932.YLR114C

Structurei

3D structure databases

ProteinModelPortaliQ12500
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 173uDENNPROSITE-ProRule annotationAdd BLAST164
Domaini195 – 360cDENNPROSITE-ProRule annotationAdd BLAST166
Domaini362 – 464dDENNPROSITE-ProRule annotationAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi603 – 682Asp-richAdd BLAST80

Sequence similaritiesi

Belongs to the AVL9 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000010255
HOGENOMiHOG000001119
InParanoidiQ12500
OrthoDBiEOG092C2X4R

Family and domain databases

InterProiView protein in InterPro
IPR018307 ABL9/DENND6_dom
IPR037516 Tripartite_DENN
PfamiView protein in Pfam
PF09794 Avl9, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

Sequencei

Sequence statusi: Complete.

Q12500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEHEEAVIF GICLVDFHHK RGPEIEYWYG LPEGTQSAEL WPNLPFQALP
60 70 80 90 100
DGSHSFEETF TYFTLLYDER RQRSPPNGAT DLSDDSINDN TTLFAISCSR
110 120 130 140 150
QIKSDELVTK DKDVTRSTVQ KAIVVISRQP IFGQIKDKLS IVTNAFFLQH
160 170 180 190 200
DFGDRKIIQS LYENLKSIYT PASLVRNAEN RLYIGLCLRK ILHDFKRNAL
210 220 230 240 250
VLLKAIMLEK KIIVYGNDVE ALCNLQFGLI SLIPDLMSNL QDSGSPQLFQ
260 270 280 290 300
DISKLNVVDS FKSSNRESVL RFLGFPLPIF EKGGLFSPYT PLQQMNDIRS
310 320 330 340 350
ERTLFFMIGS SNTLLAEQKE ELCHIFVNTD NSTVDILDKT LNPVLQLSSH
360 370 380 390 400
DKKWIESISG IVSDTWNEND DETPKNSQFE GSEDFIRWQF EDYLTGLLSS
410 420 430 440 450
VKLSDYLDLH KENDQALKTI PEDMLNSNPV HLFNLNWVQS WKETQNFLIF
460 470 480 490 500
NSRTDDRLFD LFPPKHIYNG ADTLSLLQQR FLATFHNLKR SSSNSSSNKN
510 520 530 540 550
GHQSEEDIKD QESIESKKSV SQISVNPGKN TDKPAANLWN SWKEYFNKPK
560 570 580 590 600
NTANEDVTES TEDLKNRSKT SNAIQKAMMG LGLHYKPDAE TDQQSEEVGN
610 620 630 640 650
SEDNEDDDTD EDSEDDDDDG GDDDDSEDDD DDDDGEGDEN GDDGEGDENG
660 670 680 690 700
DDGEGDENGD KEDSQDFSNG FTDVTNINTD HDKENEQNFE GNAENFNEDE
710 720 730 740 750
TVADKDIEGG PESNKNSDSK TDIYENDRNV EDSSKTRNTV KKSNEEGGAN
760
DAAIGNCVQD EEKL
Length:764
Mass (Da):86,426
Last modified:November 1, 1996 - v1
Checksum:i159A00CF933A5C4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89514 Genomic DNA Translation: CAA61692.1
U53878 Genomic DNA Translation: AAB67559.1
Z73286 Genomic DNA Translation: CAA97681.1
BK006945 Genomic DNA Translation: DAA09428.1
PIRiS64951
RefSeqiNP_013215.1, NM_001182001.1

Genome annotation databases

EnsemblFungiiYLR114C; YLR114C; YLR114C
GeneIDi850805
KEGGisce:YLR114C

Similar proteinsi

Entry informationi

Entry nameiAVL9_YEAST
AccessioniPrimary (citable) accession number: Q12500
Secondary accession number(s): D6VYB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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