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Protein

Inositol hexakisphosphate kinase 1

Gene

KCS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Involved in phosphate regulation and polyphosphate accumulation. Required for resistance to salt stress, cell wall integrity, vacuole morphogenesis, and telomere maintenance.7 Publications

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

Kineticsi

  1. KM=3.3 µM for InsP61 Publication
  2. KM=1.2 µM for InsP51 Publication
  1. Vmax=2 µmol/min/mg enzyme1 Publication

GO - Molecular functioni

GO - Biological processi

  • inositol phosphate biosynthetic process Source: SGD
  • regulation of inositol phosphate biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29635-MONOMER.
ReactomeiR-SCE-1855167. Synthesis of pyrophosphates in the cytosol.
R-SCE-1855191. Synthesis of IPs in the nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 1 (EC:2.7.4.21)
Short name:
InsP6 kinase 1
Alternative name(s):
InsP6 kinase KCS1
PKC1 suppressor protein 1
Gene namesi
Name:KCS1
Ordered Locus Names:YDR017C
ORF Names:PZF1050
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR017C.
SGDiS000002424. KCS1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002559551 – 1050Inositol hexakisphosphate kinase 1Add BLAST1050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei150PhosphoserineCombined sources1
Modified residuei396PhosphoserineCombined sources1
Modified residuei469PhosphoserineCombined sources1
Modified residuei537PhosphoserineCombined sources1
Modified residuei539PhosphoserineCombined sources1
Modified residuei566PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei589PhosphoserineCombined sources1
Modified residuei646PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei670PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12494.
PRIDEiQ12494.

PTM databases

iPTMnetiQ12494.

Interactioni

Protein-protein interaction databases

BioGridi32067. 277 interactors.
DIPiDIP-1402N.
IntActiQ12494. 5 interactors.
MINTiMINT-397897.

Structurei

3D structure databases

ProteinModelPortaliQ12494.
SMRiQ12494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni772 – 780Substrate bindingBy similarity9

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000014381.
HOGENOMiHOG000001029.
InParanoidiQ12494.
OMAiTYLRIFR.
OrthoDBiEOG092C0PWZ.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 3 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12494-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSHEIHDK IPDTLREQQQ HLRQKESEGC ITTLKDLNVP ETKKLSSVLH
60 70 80 90 100
GRKASTYLRI FRDDECLADN NNGVDSNNGG SVTCADKITR SEATPKSVPE
110 120 130 140 150
GLQVSEKKNN PDTLSSSLSS FILSNHEEPA IKPNKHVAHR NNITETGQGS
160 170 180 190 200
GEDIAKQQSH QPQVLHHQTS LKPIQNVDEG CISPKSTYQE SLHGISEDLT
210 220 230 240 250
LKPVSSATYY PHKSKADSGY EEKDKMENDI DTIQPATINC ASGIATLPSS
260 270 280 290 300
YNRHTFKVKT YSTLSQSLRQ ENVNNRSNEK KPQQFVPHSE SIKEKPNTFE
310 320 330 340 350
QDKEGEQADE EEDEGDNEHR EYPLAVELKP FTNRVGGHTA IFRFSKRAVC
360 370 380 390 400
KALVNRENRW YENIELCHKE LLQFMPRYIG VLNVRQHFQS KDDFLSDLDQ
410 420 430 440 450
ENNGKNDTSN ENKDIEVNHN NNDDIALNTE PTGTPLTHIH SFPLEHSSRQ
460 470 480 490 500
VLEKEHPEIE SVHPHVKRSL SSSNQPSLLP EVVLNDNRHI IPESLWYKYS
510 520 530 540 550
DSPNSAPNDS YFSSSSSHNS CSFGERGNTN KLKRRDSGST MINTELKNLV
560 570 580 590 600
IREVFAPKCF RRKRNSNTTT MGNHNARLGS SPSFLTQKSR ASSHDASNTS
610 620 630 640 650
MKTLGDSSSQ ASLQMDDSKV NPNLQDPFLK KSLHEKISNA LDGSHSVMDL
660 670 680 690 700
KQFHKNEQIK HKNSFCNSLS PILTATNSRD DGEFATSPNY ISNAQDGVFD
710 720 730 740 750
MDEDTGNETI NMDNHGCHLD SGKNMIIKSL AYNVSNDYSH HDIESITFEE
760 770 780 790 800
TSHTIVSKFI LLEDLTRNMN KPCALDLKMG TRQYGVDAKR AKQLSQRAKC
810 820 830 840 850
LKTTSRRLGV RICGLKVWNK DYYITRDKYF GRRVKVGWQF ARVLARFLYD
860 870 880 890 900
GKTIESLIRQ IPRLIKQLDT LYSEIFNLKG YRLYGASLLL MYDGDANKSN
910 920 930 940 950
SKRKKAANVK VNLIDFARCV TKEDAMECMD KFRIPPKSPN IEDKGFLRGV
960 970 980 990 1000
KSLRFYLLLI WNYLTSDMPL IFDEVEMNDM ISEEADSNSF TSATGSKINF
1010 1020 1030 1040 1050
NSKWDWLDEF DKEDEEMYND PNSKLRQKWR KYELIFDAEP RYNDDAQVSD
Length:1,050
Mass (Da):119,550
Last modified:November 1, 1996 - v1
Checksum:i9C7507CA5F4B0FC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81651 Genomic DNA. Translation: AAB36234.1.
X95966 Genomic DNA. Translation: CAA65208.1.
Z49770 Genomic DNA. Translation: CAA89842.1.
Z74313 Genomic DNA. Translation: CAA98837.1.
Z74314 Genomic DNA. Translation: CAA98839.1.
BK006938 Genomic DNA. Translation: DAA11863.1.
PIRiS54640.
RefSeqiNP_010300.3. NM_001180325.3.

Genome annotation databases

EnsemblFungiiYDR017C; YDR017C; YDR017C.
GeneIDi851580.
KEGGisce:YDR017C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81651 Genomic DNA. Translation: AAB36234.1.
X95966 Genomic DNA. Translation: CAA65208.1.
Z49770 Genomic DNA. Translation: CAA89842.1.
Z74313 Genomic DNA. Translation: CAA98837.1.
Z74314 Genomic DNA. Translation: CAA98839.1.
BK006938 Genomic DNA. Translation: DAA11863.1.
PIRiS54640.
RefSeqiNP_010300.3. NM_001180325.3.

3D structure databases

ProteinModelPortaliQ12494.
SMRiQ12494.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32067. 277 interactors.
DIPiDIP-1402N.
IntActiQ12494. 5 interactors.
MINTiMINT-397897.

PTM databases

iPTMnetiQ12494.

Proteomic databases

MaxQBiQ12494.
PRIDEiQ12494.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR017C; YDR017C; YDR017C.
GeneIDi851580.
KEGGisce:YDR017C.

Organism-specific databases

EuPathDBiFungiDB:YDR017C.
SGDiS000002424. KCS1.

Phylogenomic databases

GeneTreeiENSGT00390000014381.
HOGENOMiHOG000001029.
InParanoidiQ12494.
OMAiTYLRIFR.
OrthoDBiEOG092C0PWZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-29635-MONOMER.
ReactomeiR-SCE-1855167. Synthesis of pyrophosphates in the cytosol.
R-SCE-1855191. Synthesis of IPs in the nucleus.

Miscellaneous databases

PROiQ12494.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 3 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCS1_YEAST
AccessioniPrimary (citable) accession number: Q12494
Secondary accession number(s): D6VS03, P89899, Q7LGR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1940 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.