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Protein

Inner kinetochore subunit NKP1

Gene

NKP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Meiosis, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29931-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Inner kinetochore subunit NKP1Curated
Alternative name(s):
Constitutive centromere-associated network protein NKP1Curated
Non-essential kinetochore protein 1
Gene namesi
Name:NKP1
Ordered Locus Names:YDR383C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR383C
SGDiS000002791 NKP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000968671 – 238Inner kinetochore subunit NKP1Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei222PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12493
PaxDbiQ12493
PRIDEiQ12493

PTM databases

iPTMnetiQ12493

Interactioni

Subunit structurei

Component of the inner kinetochore constitutive centromere-associated network (CCAN) (also known as central kinetochore CTF19 complex in yeast), which is composed of at least AME1, CHL4, CNN1, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, MHF1, MHF2, MIF2, NKP1, NKP2, OKP1 and WIP1 (PubMed:22561346). NKP1 interacts directly with OKP1 and AME1 (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32444, 75 interactors
DIPiDIP-1940N
IntActiQ12493, 11 interactors
MINTiQ12493
STRINGi4932.YDR383C

Structurei

3D structure databases

ProteinModelPortaliQ12493
SMRiQ12493
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NKP1 family.Curated

Phylogenomic databases

InParanoidiQ12493
OMAiYELENEW
OrthoDBiEOG092C4YU8

Sequencei

Sequence statusi: Complete.

Q12493-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTYNSISN FIENELTALL SSDDYLMDDL AGELPNEVCR LLKAQVIEKR
60 70 80 90 100
KDAMSRGKQD LLSKEIYDNE SELRASQSQQ IMELVGDIPK YSLGSELRNR
110 120 130 140 150
VEGEPQSTSI ERLIEDVLKL PQMEVADEEE VEVENDLKVL SEYSNLRKDL
160 170 180 190 200
ILKCQALQIG ESKLSDILSQ TNSINSLTTS IKEASEDDDI SEYFATYNGK
210 220 230
LVVALEEMKL LLEEAVKTFG NSPEKREKIK KILSELKK
Length:238
Mass (Da):26,976
Last modified:September 13, 2005 - v2
Checksum:iA2BE651F72E76B54
GO

Sequence cautioni

The sequence AAB64819 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAB64825 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28373 Genomic DNA Translation: AAB64819.1 Different initiation.
U32274 Genomic DNA Translation: AAB64825.1 Different initiation.
BK006938 Genomic DNA Translation: DAA12227.1
PIRiS61178
RefSeqiNP_010671.4, NM_001180691.3

Genome annotation databases

EnsemblFungiiYDR383C; YDR383C; YDR383C
GeneIDi851991
KEGGisce:YDR383C

Similar proteinsi

Entry informationi

Entry nameiNKP1_YEAST
AccessioniPrimary (citable) accession number: Q12493
Secondary accession number(s): D6VT17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health