Q12487 (RM23_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
54S ribosomal protein L23, mitochondrial

Alternative name(s):
YmL23

Gene names

Name:	MRPL23
Ordered Locus Names:	YOR150W
ORF Names:	O3530

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S). Ref.5
Subcellular location	Mitochondrion Ref.7 Ref.9.
Miscellaneous	Present with 6700 molecules/cell in log phase SD medium. Ref.8
Sequence similarities	Belongs to the ribosomal protein L13P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	mitochondrial translation Inferred by curator Ref.6Ref.5. Source: SGD
Cellular component	mitochondrial large ribosomal subunit Inferred from direct assay Ref.5. Source: SGD
Molecular function	structural constituent of ribosome Inferred from direct assay Ref.5. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 4	4			PRO_0000030462
	Chain	5 – 163	159	54S ribosomal protein L23, mitochondrial		PRO_0000030463
Experimental info
	Sequence conflict	5	1	I → K AA sequence Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q12487 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5FD27E5A965F6315	FASTA	163	18,463
	10 20 30 40 50 60 MSQKIGHSGL AFARLWHHVD VARDKRTLGR LASAIAITLI GRHKPVYHPS QDCGDYVVVT 70 80 90 100 110 120 NCQKIRVTGK KFEQKTYWSH SGRPGQLKLQ TMNKVVADKG FGEILKKAVS GMLPKNKLRK 130 140 150 160 QRLDRLKVFD GSENPYKQNI TAFAHEQSSI PEPLKESIFN QLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of a 35.6 kb region on the right arm of Saccharomyces cerevisiae chromosome XV." Bordonne R., Camasses A., Madania A., Poch O., Tarassov I.A., Winsor B., Martin R.P. Yeast 13:73-83(1997) [PubMed: 9046089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: S288c / FY1678.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed: 9169874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S288c / FY1678.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Identification and characterization of the genes for mitochondrial ribosomal proteins of Saccharomyces cerevisiae." Kitakawa M., Graack H.-R., Grohmann L., Goldschmidt-Reisin S., Herfurth E., Wittmann-Liebold B., Nishimura T., Isono K. Eur. J. Biochem. 245:449-456(1997) [PubMed: 9151978] [Abstract] Cited for: PROTEIN SEQUENCE OF 5-18, SUBUNIT. Strain: 07173.
[6]	"Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components." Gan X., Kitakawa M., Yoshino K., Oshiro N., Yonezawa K., Isono K. Eur. J. Biochem. 269:5203-5214(2002) [PubMed: 12392552] [Abstract] Cited for: IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOMAL LARGE COMPLEX, MASS SPECTROMETRY.
[7]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]	"The proteome of Saccharomyces cerevisiae mitochondria." Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C. Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed: 14576278] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Strain: ATCC 76625 / YPH499.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U55020 Genomic DNA. Translation: AAC49636.1. Z75058 Genomic DNA. Translation: CAA99356.1. AY558133 Genomic DNA. Translation: AAS56459.1. BK006948 Genomic DNA. Translation: DAA10923.1.
PIR	S67038.
RefSeq	NP_014793.1. NM_001183569.1.
3D structure databases
ProteinModelPortal	Q12487.
SMR	Q12487. Positions 9-143.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5385N.
IntAct	Q12487. 6 interactions.
MINT	MINT-502479.
STRING	Q12487.
Proteomic databases
PeptideAtlas	Q12487.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YOR150W; YOR150W; YOR150W.
GeneID	854321.
KEGG	sce:YOR150W.
NMPDR	fig|4932.3.peg.5898.
Organism-specific databases
CYGD	YOR150w.
SGD	S000005676. MRPL23.
Phylogenomic databases
eggNOG	fuNOG08506.
GeneTree	EFGT00050000003376.
HOGENOM	HBG380826.
OMA	YTPHMDC.
OrthoDB	EOG46T69R.
Gene expression databases
ArrayExpress	Q12487.
Genevestigator	Q12487.
GermOnline	YOR150W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR005822. Ribosomal_L13. IPR005823. Ribosomal_L13_bac-type. IPR023563. Ribosomal_L13_CS. IPR023564. Ribosomal_L13_dom. [Graphical view]
Gene3D	G3DSA:3.90.1180.10. Ribosomal_L13. 1 hit.
KO	K02871.
PANTHER	PTHR11545. Ribosomal_L13. 1 hit.
Pfam	PF00572. Ribosomal_L13. 1 hit. [Graphical view]
PIRSF	PIRSF002181. Ribosomal_L13. 1 hit.
SUPFAM	SSF52161. Ribosomal_L13. 1 hit.
TIGRFAMs	TIGR01066. RplM_bact. 1 hit.
PROSITE	PS00783. RIBOSOMAL_L13. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	976357.

Entry information

Entry name

RM23_YEAST

Accession

Primary (citable) accession number: Q12487
Secondary accession number(s): D6W2K7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program