Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

54S ribosomal protein L23, mitochondrial

Gene

MRPL23

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

Miscellaneous

Present with 6700 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-33667-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
54S ribosomal protein L23, mitochondrial
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL13m1 Publication
YmL23
Gene namesi
Name:MRPL23
Ordered Locus Names:YOR150W
ORF Names:O3530
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR150W
SGDiS000005676 MRPL23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
PropeptideiPRO_00000304622 – 41 Publication3
ChainiPRO_00000304635 – 16354S ribosomal protein L23, mitochondrialAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ12487
PaxDbiQ12487
PRIDEiQ12487

PTM databases

iPTMnetiQ12487

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.3 Publications

Protein-protein interaction databases

BioGridi34546, 20 interactors
DIPiDIP-5385N
IntActiQ12487, 8 interactors
STRINGi4932.YOR150W

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Belectron microscopy3.20H1-163[»]
5MRCelectron microscopy3.25H2-161[»]
5MREelectron microscopy3.75H2-161[»]
5MRFelectron microscopy4.97H2-161[»]
ProteinModelPortaliQ12487
SMRiQ12487
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000001515
HOGENOMiHOG000225288
InParanoidiQ12487
KOiK02871
OMAiVLMGKHK
OrthoDBiEOG092C59OH

Family and domain databases

CDDicd00392 Ribosomal_L13, 1 hit
Gene3Di3.90.1180.10, 1 hit
HAMAPiMF_01366 Ribosomal_L13, 1 hit
InterProiView protein in InterPro
IPR005822 Ribosomal_L13
IPR005823 Ribosomal_L13_bac-type
IPR023563 Ribosomal_L13_CS
IPR036899 Ribosomal_L13_sf
PANTHERiPTHR11545 PTHR11545, 1 hit
PfamiView protein in Pfam
PF00572 Ribosomal_L13, 1 hit
PIRSFiPIRSF002181 Ribosomal_L13, 1 hit
SUPFAMiSSF52161 SSF52161, 1 hit
TIGRFAMsiTIGR01066 rplM_bact, 1 hit
PROSITEiView protein in PROSITE
PS00783 RIBOSOMAL_L13, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKIGHSGL AFARLWHHVD VARDKRTLGR LASAIAITLI GRHKPVYHPS
60 70 80 90 100
QDCGDYVVVT NCQKIRVTGK KFEQKTYWSH SGRPGQLKLQ TMNKVVADKG
110 120 130 140 150
FGEILKKAVS GMLPKNKLRK QRLDRLKVFD GSENPYKQNI TAFAHEQSSI
160
PEPLKESIFN QLK
Length:163
Mass (Da):18,463
Last modified:November 1, 1996 - v1
Checksum:i5FD27E5A965F6315
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5I → K AA sequence (PubMed:9151978).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55020 Genomic DNA Translation: AAC49636.1
Z75058 Genomic DNA Translation: CAA99356.1
AY558133 Genomic DNA Translation: AAS56459.1
BK006948 Genomic DNA Translation: DAA10923.1
PIRiS67038
RefSeqiNP_014793.1, NM_001183569.1

Genome annotation databases

EnsemblFungiiYOR150W; YOR150W; YOR150W
GeneIDi854321
KEGGisce:YOR150W

Similar proteinsi

Entry informationi

Entry nameiRM23_YEAST
AccessioniPrimary (citable) accession number: Q12487
Secondary accession number(s): D6W2K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health