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Protein

Mitochondrial aspartate-glutamate transporter AGC1

Gene

AGC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.2 Publications

GO - Molecular functioni

  • antiporter activity Source: SGD
  • L-aspartate transmembrane transporter activity Source: SGD
  • L-glutamate transmembrane transporter activity Source: SGD
  • uniporter activity Source: SGD

GO - Biological processi

  • aspartate transmembrane transport Source: SGD
  • cellular nitrogen compound biosynthetic process Source: SGD
  • L-glutamate transmembrane transport Source: SGD
  • malate-aspartate shuttle Source: GO_Central

Keywordsi

Biological processAmino-acid transport, Transport
LigandCalcium

Enzyme and pathway databases

BioCyciYEAST:G3O-34181-MONOMER
ReactomeiR-SCE-428643 Organic anion transporters
R-SCE-70263 Gluconeogenesis

Protein family/group databases

TCDBi2.A.29.14.4 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial aspartate-glutamate transporter AGC1
Alternative name(s):
Aspartate-glutamate carrier 1
Gene namesi
Name:AGC1
Ordered Locus Names:YPR021C
ORF Names:YP9367.01C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR021C
SGDiS000006225 AGC1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei534 – 554Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei591 – 611Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei622 – 642Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei681 – 702Helical; Name=4Sequence analysisAdd BLAST22
Transmembranei731 – 751Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei786 – 806Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002276011 – 902Mitochondrial aspartate-glutamate transporter AGC1Add BLAST902

Proteomic databases

MaxQBiQ12482
PaxDbiQ12482
PRIDEiQ12482

PTM databases

iPTMnetiQ12482

Interactioni

Protein-protein interaction databases

BioGridi36198, 98 interactors
DIPiDIP-8968N
STRINGi4932.YPR021C

Structurei

3D structure databases

ProteinModelPortaliQ12482
SMRiQ12482
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati528 – 614Solcar 1Add BLAST87
Repeati622 – 710Solcar 2Add BLAST89
Repeati725 – 813Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000062944
HOGENOMiHOG000180633
InParanoidiQ12482
KOiK15105
OMAiYYYKSCQ
OrthoDBiEOG092C0E6C

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q12482-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQINSNSRK KKQQLEVFKY FASVLTKEDK PISISNGMLD MPTVNSSKLT
60 70 80 90 100
AGNGKPDTEK LTGELILTYD DFIELISSSK TIYSKFTDHS FNLNQIPKNV
110 120 130 140 150
FGCIFFAIDE QNKGYLTLND WFYFNNLLEY DNYHLIILYE FFRKFDVENL
160 170 180 190 200
KAKQKKELGS SSFNLKAADD RIKSINYGNR FLSFDDLLLN LNQFKDTIRL
210 220 230 240 250
LHESIDDNFV KDNKLLLDWN DFRFLKFYKC YHENEEYLSL NSLVTILQND
260 270 280 290 300
LKNEKIFIGF DRLAQMDSQG HRLALSKNQL TYLLRLFYSH RVSADIFSSL
310 320 330 340 350
NLSNTELLKA DNNSIPYNVF KDIFYLFQNF DLLNQIFHKY VTENNLNEQD
360 370 380 390 400
IREQIVTKND FMTVLNAQYN KVNNIIEFSP SQINLLFSIV ANSKENRRLR
410 420 430 440 450
KRNQDRDDEL LNDHHYDSDI DFFIHNEYLH GVSRSRKNLE SFNDYYHDLS
460 470 480 490 500
DGFDQDSGVK KASKASTGLF ESVFGGKKDK ATMRSDLTIE DFMKILNPNY
510 520 530 540 550
LNDLVHQMEL QKNQNESLYI NYYFYPIFDS LYNFSLGSIA GCIGATVVYP
560 570 580 590 600
IDFIKTRMQA QRSLAQYKNS IDCLLKIISR EGIKGLYSGL GPQLIGVAPE
610 620 630 640 650
KAIKLTVNDF MRNRLTDKNG KLSLFPEIIS GASAGACQVI FTNPLEIVKI
660 670 680 690 700
RLQVQSDYVG ENIQQANETA TQIVKKLGLR GLYNGVAACL MRDVPFSAIY
710 720 730 740 750
FPTYAHLKKD LFDFDPNDKT KRNRLKTWEL LTAGAIAGMP AAFLTTPFDV
760 770 780 790 800
IKTRLQIDPR KGETKYNGIF HAIRTILKEE SFRSFFKGGG ARVLRSSPQF
810 820 830 840 850
GFTLAAYELF KGFIPSPDNK LKSREGRKRF CIDDDAGNEE TVVHSNGELP
860 870 880 890 900
QQKFYSDDRK HANYYYKSCQ IAKTFIDLDN NFSRFDSSVY KNFQEHLRSI

NG
Length:902
Mass (Da):104,304
Last modified:November 1, 1996 - v1
Checksum:i07D6F831E2CD15CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA Translation: CAA95017.1
Z49274 Genomic DNA Translation: CAA89275.1
BK006949 Genomic DNA Translation: DAA11447.1
PIRiS54495
RefSeqiNP_015346.1, NM_001184118.1

Genome annotation databases

EnsemblFungiiYPR021C; YPR021C; YPR021C
GeneIDi856132
KEGGisce:YPR021C

Similar proteinsi

Entry informationi

Entry nameiAGC1_YEAST
AccessioniPrimary (citable) accession number: Q12482
Secondary accession number(s): D6W431
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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