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Protein

PHO85 cyclin-9

Gene

PCL9

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. May have a role in bud site selection in G1 phase.2 Publications

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-29566-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PHO85 cyclin-9
Gene namesi
Name:PCL9
Ordered Locus Names:YDL179W
ORF Names:D1408
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL179W.
SGDiS000002338. PCL9.

Subcellular locationi

GO - Cellular componenti

  • cellular bud neck Source: SGD
  • cyclin-dependent protein kinase holoenzyme complex Source: SGD
  • incipient cellular bud site Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002717881 – 304PHO85 cyclin-9Add BLAST304

Proteomic databases

PRIDEiQ12477.

Expressioni

Inductioni

By transcription factor SWI5 in a cell cycle-regulated manner. Peaks in late M, early G1 phase (at protein level).2 Publications

Interactioni

Subunit structurei

Forms a cyclin-CDK complex with PHO85.

Binary interactionsi

WithEntry#Exp.IntActNotes
PHO85P171574EBI-38090,EBI-13327

Protein-protein interaction databases

BioGridi31887. 22 interactors.
DIPiDIP-1510N.
IntActiQ12477. 4 interactors.
MINTiMINT-408364.

Structurei

3D structure databases

ProteinModelPortaliQ12477.
SMRiQ12477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 146Cyclin N-terminalAdd BLAST128

Sequence similaritiesi

Belongs to the cyclin family. PCL1,2 subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

GeneTreeiENSGT00390000004809.
HOGENOMiHOG000000866.
InParanoidiQ12477.
OrthoDBiEOG092C3KSL.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR006671. Cyclin_N.
IPR012104. PHO85_cyclin_1/2/9.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF016511. Cyclin_Pcl. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12477-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISDYDALLQ FNKKPVSQEM IQFLATSTAS IIKIRENNNP IQGCRPPDLS
60 70 80 90 100
IFIKNVVIQS NVQTPTLMAT SVYLNKLKSV IPKNVYGINT TRHRIFLGCL
110 120 130 140 150
ILAAKTLNDS SPWNKHWTTY TEGLLRIREV NTIERELLEY LNWDVRITTP
160 170 180 190 200
DLIDSLSYFL GPIKEQLFLQ RRQEMLLFNA PSPGQLKEYI NHRRPVSHSR
210 220 230 240 250
TSSAISVPSL TSMATVSTTD SRSSLLAKYQ PSLPLVESDN FNKKNHVPLR
260 270 280 290 300
NNNDICNNFR AEENIHSVNH IDVTMGSSPV MSHKPTIHQR LNFTRRGWSS

FFKQ
Length:304
Mass (Da):34,798
Last modified:November 1, 1996 - v1
Checksum:i183820067EC00D23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67750 Genomic DNA. Translation: CAA91566.1.
Z74227 Genomic DNA. Translation: CAA98753.1.
AY557655 Genomic DNA. Translation: AAS55981.1.
BK006938 Genomic DNA. Translation: DAA11683.1.
PIRiS61033.
RefSeqiNP_010102.1. NM_001180239.1.

Genome annotation databases

EnsemblFungiiYDL179W; YDL179W; YDL179W.
GeneIDi851375.
KEGGisce:YDL179W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67750 Genomic DNA. Translation: CAA91566.1.
Z74227 Genomic DNA. Translation: CAA98753.1.
AY557655 Genomic DNA. Translation: AAS55981.1.
BK006938 Genomic DNA. Translation: DAA11683.1.
PIRiS61033.
RefSeqiNP_010102.1. NM_001180239.1.

3D structure databases

ProteinModelPortaliQ12477.
SMRiQ12477.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31887. 22 interactors.
DIPiDIP-1510N.
IntActiQ12477. 4 interactors.
MINTiMINT-408364.

Proteomic databases

PRIDEiQ12477.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL179W; YDL179W; YDL179W.
GeneIDi851375.
KEGGisce:YDL179W.

Organism-specific databases

EuPathDBiFungiDB:YDL179W.
SGDiS000002338. PCL9.

Phylogenomic databases

GeneTreeiENSGT00390000004809.
HOGENOMiHOG000000866.
InParanoidiQ12477.
OrthoDBiEOG092C3KSL.

Enzyme and pathway databases

BioCyciYEAST:G3O-29566-MONOMER.

Miscellaneous databases

PROiQ12477.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR006671. Cyclin_N.
IPR012104. PHO85_cyclin_1/2/9.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF016511. Cyclin_Pcl. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPCL9_YEAST
AccessioniPrimary (citable) accession number: Q12477
Secondary accession number(s): D6VRH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.