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Protein

Serine/threonine-protein kinase SKM1

Gene

SKM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in cellular signaling or cytoskeletal functions. May play a role in morphogenetic control.

Miscellaneous

Present with 238 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei406ATPPROSITE-ProRule annotation1
Active sitei507Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi366 – 374ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD
  • Rac GTPase binding Source: GO_Central

GO - Biological processi

  • actin cytoskeleton organization Source: GO_Central
  • activation of protein kinase activity Source: GO_Central
  • cell separation after cytokinesis Source: SGD
  • negative regulation of gene expression Source: SGD
  • negative regulation of sterol import by negative regulation of transcription from RNA polymerase II promoter Source: SGD
  • protein phosphorylation Source: SGD
  • regulation of apoptotic process Source: GO_Central
  • regulation of MAPK cascade Source: GO_Central
  • regulation of mitotic cell cycle Source: GO_Central
  • Rho protein signal transduction Source: GO_Central
  • signal transduction by protein phosphorylation Source: GO_Central
  • sterol import Source: SGD
  • stress-activated protein kinase signaling cascade Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-33510-MONOMER
BRENDAi2.7.11.1 984

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SKM1 (EC:2.7.11.1)
Alternative name(s):
Protein kinase 75490 D
Gene namesi
Name:SKM1
Ordered Locus Names:YOL113W
ORF Names:HRA655
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL113W
SGDiS000005473 SKM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000866561 – 655Serine/threonine-protein kinase SKM1Add BLAST655

Proteomic databases

MaxQBiQ12469
PaxDbiQ12469
PRIDEiQ12469

PTM databases

iPTMnetiQ12469

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi34287, 134 interactors
DIPiDIP-4217N
IntActiQ12469, 13 interactors
MINTiQ12469
STRINGi4932.YOL113W

Structurei

3D structure databases

ProteinModelPortaliQ12469
SMRiQ12469
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 118PHPROSITE-ProRule annotationAdd BLAST116
Domaini123 – 136CRIBPROSITE-ProRule annotationAdd BLAST14
Domaini360 – 639Protein kinasePROSITE-ProRule annotationAdd BLAST280

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00910000145970
HOGENOMiHOG000234202
InParanoidiQ12469
KOiK19833
OMAiYCAKLTD
OrthoDBiEOG092C2E30

Family and domain databases

CDDicd01093 CRIB_PAK_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.90.810.10, 1 hit
InterProiView protein in InterPro
IPR000095 CRIB_dom
IPR036936 CRIB_dom_sf
IPR011009 Kinase-like_dom_sf
IPR033923 PAK_BD
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00786 PBD, 1 hit
PF00169 PH, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
SM00233 PH, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q12469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGVKKEGWI SYKVDGLFSF LWQKRYLVLN DSYLAFYKSD KCNEEPVLSV
60 70 80 90 100
PLTSITNVSR IQLKQNCFEI LRATDQKENI SPINSYFYES NSKRSIFIST
110 120 130 140 150
RTERDLHGWL DAIFAKCPLL SGVSSPTNFT HKVHVGFDPK VGNFVGVPDS
160 170 180 190 200
WAKLLQTSEI TYDDWNRNSK AVIKALQFYE DYNGLDTMQF NDHLNTSLDL
210 220 230 240 250
KPLKSPTRYI INKRTNSIKR SVSRTLRKGK TDSILPVYQS ELKPFPRPSD
260 270 280 290 300
DDYKFTNIED NKVREEGRVH VSKESTADSQ TKQLGKKEQK VIQSHLRRHD
310 320 330 340 350
NNSTFRPHRL APSAPATKNH DSKTKWHKED LLELKNNDDS NEIIMKMKTV
360 370 380 390 400
AIDVNPRPYF QLVEKAGQGA SGAVYLSKRI KLPQENDPRF LKSHCHRVVG
410 420 430 440 450
ERVAIKQIRL SEQPKKQLIM NELLVMNDSR QENIVNFLEA YIIDDEELWV
460 470 480 490 500
IMEYMEGGCL TDILDAVARS NTGEHSSPLN ENQMAYIVKE TCQGLKFLHN
510 520 530 540 550
KKIIHRDIKS DNILLNSQGL VKITDFGFCV ELTEKRSKRA TMVGTPYWMA
560 570 580 590 600
PEIVNQKGYD EKVDVWSLGI MLIEMIEGEP PYLNEDPLKA LYLIANNGSP
610 620 630 640 650
KLRHPESVSK QTKQFLDACL QVNVESRASV RKLLTFEFLS MACSPEQLKV

SLKWH
Length:655
Mass (Da):75,331
Last modified:November 1, 1996 - v1
Checksum:i1F6CBC85FE10D385
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150S → R in AAT93238 (PubMed:17322287).Curated1
Sequence conflicti303S → A in CAA49163 (PubMed:9044278).Curated1
Sequence conflicti306R → K in CAA49163 (PubMed:9044278).Curated1
Sequence conflicti320H → Y (PubMed:9044278).Curated1
Sequence conflicti322S → R (PubMed:9044278).Curated1
Sequence conflicti452M → T in CAA49163 (PubMed:9044278).Curated1
Sequence conflicti468A → V in CAA49163 (PubMed:9044278).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69322 Genomic DNA Translation: CAA49163.1
Z48149 Genomic DNA Translation: CAA88147.1
Z74855 Genomic DNA Translation: CAA99132.1
AY693219 Genomic DNA Translation: AAT93238.1
BK006948 Genomic DNA Translation: DAA10670.1
PIRiS51884
RefSeqiNP_014528.1, NM_001183367.1

Genome annotation databases

EnsemblFungiiYOL113W; YOL113W; YOL113W
GeneIDi854036
KEGGisce:YOL113W

Similar proteinsi

Entry informationi

Entry nameiSKM1_YEAST
AccessioniPrimary (citable) accession number: Q12469
Secondary accession number(s): D6W1V4, E9P934, Q06940
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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