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Q12462

- PEX11_YEAST

UniProt

Q12462 - PEX11_YEAST

Protein

Peroxisomal membrane protein PMP27

Gene

PEX11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in peroxisomal proliferation. Promotes peroxisome division and biogenesis.3 Publications

    GO - Biological processi

    1. fatty acid oxidation Source: SGD
    2. peroxisome fission Source: UniProtKB
    3. peroxisome organization Source: UniProtKB
    4. regulation of peroxisome size Source: UniProtKB
    5. signal transduction Source: UniProtKB

    Keywords - Biological processi

    Peroxisome biogenesis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33537-MONOMER.
    ReactomeiREACT_188984. PPARA activates gene expression.

    Protein family/group databases

    TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal membrane protein PMP27
    Alternative name(s):
    Peroxin-11
    Gene namesi
    Name:PEX11
    Synonyms:PMP24, PMP27
    Ordered Locus Names:YOL147C
    ORF Names:O0454
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    SGDiS000005507. PEX11.

    Subcellular locationi

    Peroxisome membrane 2 Publications; Peripheral membrane protein 2 Publications

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. integral component of peroxisomal membrane Source: UniProtKB
    3. peroxisomal membrane Source: SGD
    4. peroxisome Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 236235Peroxisomal membrane protein PMP27PRO_0000105974Add
    BLAST

    Proteomic databases

    MaxQBiQ12462.
    PaxDbiQ12462.
    PeptideAtlasiQ12462.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12462.

    Interactioni

    Subunit structurei

    Homooligomer. Interacts with PEX34.3 Publications

    Protein-protein interaction databases

    BioGridi34270. 42 interactions.
    DIPiDIP-3839N.
    IntActiQ12462. 28 interactions.
    MINTiMINT-500737.
    STRINGi4932.YOL147C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12462.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peroxin-11 family.Curated

    Phylogenomic databases

    eggNOGiNOG328843.
    HOGENOMiHOG000214966.
    OMAiYLHFTEG.
    OrthoDBiEOG7XSTRS.

    Family and domain databases

    InterProiIPR008733. PEX11.
    [Graphical view]
    PfamiPF05648. PEX11. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q12462-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVCDTLVYHP SVTRFVKFLD GSAGREKVLR LLQYLARFLA VQNSSLLARQ    50
    LQAQFTTVRK FLRFLKPLNH LQAAAKFYDN KLASDNVVRV CNVLKNIFFA 100
    AYLSLDQVNL LRILKVIPVT VLTGKKIPRW SNWCWLFGLL SGLAMDLRKI 150
    QTSHAQIAAF VKAKSQSQGD EHEDHKKVLG KAYQDRYTAL RRLFWDAADS 200
    FIVLNNLGYL SSNEEYVALS GVVTSILGMQ DMWKAT 236
    Length:236
    Mass (Da):26,875
    Last modified:January 23, 2007 - v2
    Checksum:i26B95896D57018DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48239 Genomic DNA. Translation: CAA88280.1.
    Z74889 Genomic DNA. Translation: CAA99168.1.
    X81465 Genomic DNA. Translation: CAA57223.1.
    Z46846 Genomic DNA. Translation: CAA86903.1.
    AY558010 Genomic DNA. Translation: AAS56336.1.
    BK006948 Genomic DNA. Translation: DAA10638.1.
    PIRiA56509.
    RefSeqiNP_014494.1. NM_001183401.1.

    Genome annotation databases

    EnsemblFungiiYOL147C; YOL147C; YOL147C.
    GeneIDi854018.
    KEGGisce:YOL147C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48239 Genomic DNA. Translation: CAA88280.1 .
    Z74889 Genomic DNA. Translation: CAA99168.1 .
    X81465 Genomic DNA. Translation: CAA57223.1 .
    Z46846 Genomic DNA. Translation: CAA86903.1 .
    AY558010 Genomic DNA. Translation: AAS56336.1 .
    BK006948 Genomic DNA. Translation: DAA10638.1 .
    PIRi A56509.
    RefSeqi NP_014494.1. NM_001183401.1.

    3D structure databases

    ProteinModelPortali Q12462.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34270. 42 interactions.
    DIPi DIP-3839N.
    IntActi Q12462. 28 interactions.
    MINTi MINT-500737.
    STRINGi 4932.YOL147C.

    Protein family/group databases

    TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.

    Proteomic databases

    MaxQBi Q12462.
    PaxDbi Q12462.
    PeptideAtlasi Q12462.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOL147C ; YOL147C ; YOL147C .
    GeneIDi 854018.
    KEGGi sce:YOL147C.

    Organism-specific databases

    SGDi S000005507. PEX11.

    Phylogenomic databases

    eggNOGi NOG328843.
    HOGENOMi HOG000214966.
    OMAi YLHFTEG.
    OrthoDBi EOG7XSTRS.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33537-MONOMER.
    Reactomei REACT_188984. PPARA activates gene expression.

    Miscellaneous databases

    NextBioi 975544.

    Gene expression databases

    Genevestigatori Q12462.

    Family and domain databases

    InterProi IPR008733. PEX11.
    [Graphical view ]
    Pfami PF05648. PEX11. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p."
      Erdmann R., Blobel G.
      J. Cell Biol. 128:509-523(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-28.
      Strain: ATCC 204508 / S288c.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-30 AND 192-207.
      Strain: S288c / GRF88.
    3. "DNA sequence analysis of a 13 kbp fragment of the left arm of yeast chromosome XV containing seven new open reading frames."
      Casamayor A., Aldea M., Casas C., Herrero E., Gamo F.-J., Lafuente M.J., Gancedo C., Arino J.
      Yeast 11:1281-1288(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 96604 / S288c / FY1679.
    4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast."
      Tower R.J., Fagarasanu A., Aitchison J.D., Rachubinski R.A.
      Mol. Biol. Cell 22:1727-1738(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PEX34.
    6. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    8. "Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae."
      Tam Y.Y.C., Torres-Guzman J.C., Vizeacoumar F.J., Smith J.J., Marelli M., Aitchison J.D., Rachubinski R.A.
      Mol. Biol. Cell 14:4089-4102(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.
    9. "Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis."
      Rottensteiner H., Stein K., Sonnenhol E., Erdmann R.
      Mol. Biol. Cell 14:4316-4328(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
      Strain: ATCC 201389 / BY4742.
    10. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    11. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPEX11_YEAST
    AccessioniPrimary (citable) accession number: Q12462
    Secondary accession number(s): D6W1S2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1630 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3