Q12462 (PEX11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisomal membrane protein PMP27

Alternative name(s):
Peroxin-11

Gene names

Name:	PEX11
Synonyms:	PMP24, PMP27
Ordered Locus Names:	YOL147C
ORF Names:	O0454

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in peroxisomal proliferation. Promotes peroxisome division and biogenesis. Ref.5 Ref.8 Ref.9
Subunit structure	Homooligomer. Interacts with PEX34. Ref.5 Ref.8 Ref.9
Subcellular location	Peroxisome membrane; Peripheral membrane protein Ref.9 Ref.10.
Miscellaneous	Present with 1630 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the peroxin-11 family.

Ontologies

Keywords
Biological process	Peroxisome biogenesis
Cellular component	Membrane Peroxisome
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid oxidation Inferred from mutant phenotype PubMed 10931862. Source: SGD peroxisome fission Inferred from direct assay PubMed 20826455. Source: UniProtKB regulation of peroxisome size Inferred from direct assay PubMed 20826455. Source: UniProtKB signal transduction Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	endoplasmic reticulum Inferred from direct assay PubMed 20028986. Source: SGD integral to peroxisomal membrane Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1 Ref.2
	Chain	2 – 236	235	Peroxisomal membrane protein PMP27		PRO_0000105974

Sequences

	Sequence		Length	Mass (Da)
	Q12462 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 26B95896D57018DD	FASTA	236	26,875
	10 20 30 40 50 60 MVCDTLVYHP SVTRFVKFLD GSAGREKVLR LLQYLARFLA VQNSSLLARQ LQAQFTTVRK 70 80 90 100 110 120 FLRFLKPLNH LQAAAKFYDN KLASDNVVRV CNVLKNIFFA AYLSLDQVNL LRILKVIPVT 130 140 150 160 170 180 VLTGKKIPRW SNWCWLFGLL SGLAMDLRKI QTSHAQIAAF VKAKSQSQGD EHEDHKKVLG 190 200 210 220 230 KAYQDRYTAL RRLFWDAADS FIVLNNLGYL SSNEEYVALS GVVTSILGMQ DMWKAT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p." Erdmann R., Blobel G. J. Cell Biol. 128:509-523(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-28. Strain: ATCC 204508 / S288c.
[2]	"Pmp27 promotes peroxisomal proliferation." Marshall P.A., Krimkevich Y.I., Lark R.H., Dyer J.M., Veenhuis M., Goodman J.M. J. Cell Biol. 129:345-355(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-30 AND 192-207. Strain: S288c / GRF88.
[3]	"DNA sequence analysis of a 13 kbp fragment of the left arm of yeast chromosome XV containing seven new open reading frames." Casamayor A., Aldea M., Casas C., Herrero E., Gamo F.-J., Lafuente M.J., Gancedo C., Arino J. Yeast 11:1281-1288(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[4]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[5]	"The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast." Tower R.J., Fagarasanu A., Aitchison J.D., Rachubinski R.A. Mol. Biol. Cell 22:1727-1738(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH PEX34.
[6]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[7]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[8]	"Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae." Tam Y.Y.C., Torres-Guzman J.C., Vizeacoumar F.J., Smith J.J., Marelli M., Aitchison J.D., Rachubinski R.A. Mol. Biol. Cell 14:4089-4102(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT.
[9]	"Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis." Rottensteiner H., Stein K., Sonnenhol E., Erdmann R. Mol. Biol. Cell 14:4316-4328(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION. Strain: ATCC 201389 / BY4742.
[10]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[11]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z48239 Genomic DNA. Translation: CAA88280.1. Z74889 Genomic DNA. Translation: CAA99168.1. X81465 Genomic DNA. Translation: CAA57223.1. Z46846 Genomic DNA. Translation: CAA86903.1. AY558010 Genomic DNA. Translation: AAS56336.1. BK006948 Genomic DNA. Translation: DAA10638.1.
PIR	A56509.
RefSeq	NP_014494.1. NM_001183401.1.
3D structure databases
ProteinModelPortal	Q12462.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3839N.
IntAct	Q12462. 28 interactions.
MINT	MINT-500737.
STRING	4932.YOL147C.
Proteomic databases
PaxDb	Q12462.
PeptideAtlas	Q12462.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YOL147C; YOL147C; YOL147C.
GeneID	854018.
KEGG	sce:YOL147C.
Organism-specific databases
SGD	S000005507. PEX11.
Phylogenomic databases
eggNOG	NOG328843.
HOGENOM	HOG000214966.
OMA	QLGYAGY.
OrthoDB	EOG4WM83V.
Gene expression databases
Genevestigator	Q12462.
GermOnline	YOL147C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR008733. PEX11. [Graphical view]
PANTHER	PTHR12652. PTHR12652. 1 hit.
Pfam	PF05648. PEX11. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	975544.

Entry information

Entry name

PEX11_YEAST

Accession

Primary (citable) accession number: Q12462
Secondary accession number(s): D6W1S2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program