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Q12462 (PEX11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal membrane protein PMP27
Alternative name(s):
Peroxin-11
Gene names
Name:PEX11
Synonyms:PMP24, PMP27
Ordered Locus Names:YOL147C
ORF Names:O0454
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in peroxisomal proliferation. Promotes peroxisome division and biogenesis. Ref.5 Ref.8 Ref.9

Subunit structure

Homooligomer. Interacts with PEX34. Ref.5 Ref.8 Ref.9

Subcellular location

Peroxisome membrane; Peripheral membrane protein Ref.9 Ref.10.

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the peroxin-11 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1 Ref.2
Chain2 – 236235Peroxisomal membrane protein PMP27
PRO_0000105974

Sequences

Sequence LengthMass (Da)Tools
Q12462 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 26B95896D57018DD

FASTA23626,875
        10         20         30         40         50         60 
MVCDTLVYHP SVTRFVKFLD GSAGREKVLR LLQYLARFLA VQNSSLLARQ LQAQFTTVRK 

        70         80         90        100        110        120 
FLRFLKPLNH LQAAAKFYDN KLASDNVVRV CNVLKNIFFA AYLSLDQVNL LRILKVIPVT 

       130        140        150        160        170        180 
VLTGKKIPRW SNWCWLFGLL SGLAMDLRKI QTSHAQIAAF VKAKSQSQGD EHEDHKKVLG 

       190        200        210        220        230 
KAYQDRYTAL RRLFWDAADS FIVLNNLGYL SSNEEYVALS GVVTSILGMQ DMWKAT 

« Hide

References

« Hide 'large scale' references
[1]"Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p."
Erdmann R., Blobel G.
J. Cell Biol. 128:509-523(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-28.
Strain: ATCC 204508 / S288c.
[2]"Pmp27 promotes peroxisomal proliferation."
Marshall P.A., Krimkevich Y.I., Lark R.H., Dyer J.M., Veenhuis M., Goodman J.M.
J. Cell Biol. 129:345-355(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-30 AND 192-207.
Strain: S288c / GRF88.
[3]"DNA sequence analysis of a 13 kbp fragment of the left arm of yeast chromosome XV containing seven new open reading frames."
Casamayor A., Aldea M., Casas C., Herrero E., Gamo F.-J., Lafuente M.J., Gancedo C., Arino J.
Yeast 11:1281-1288(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[4]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[5]"The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast."
Tower R.J., Fagarasanu A., Aitchison J.D., Rachubinski R.A.
Mol. Biol. Cell 22:1727-1738(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH PEX34.
[6]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[7]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[8]"Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae."
Tam Y.Y.C., Torres-Guzman J.C., Vizeacoumar F.J., Smith J.J., Marelli M., Aitchison J.D., Rachubinski R.A.
Mol. Biol. Cell 14:4089-4102(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[9]"Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis."
Rottensteiner H., Stein K., Sonnenhol E., Erdmann R.
Mol. Biol. Cell 14:4316-4328(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
Strain: ATCC 201389 / BY4742.
[10]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[11]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[12]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z48239 Genomic DNA. Translation: CAA88280.1.
Z74889 Genomic DNA. Translation: CAA99168.1.
X81465 Genomic DNA. Translation: CAA57223.1.
Z46846 Genomic DNA. Translation: CAA86903.1.
AY558010 Genomic DNA. Translation: AAS56336.1.
BK006948 Genomic DNA. Translation: DAA10638.1.
PIRA56509.
RefSeqNP_014494.1. NM_001183401.1.

3D structure databases

ProteinModelPortalQ12462.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid34270. 42 interactions.
DIPDIP-3839N.
IntActQ12462. 28 interactions.
MINTMINT-500737.
STRING4932.YOL147C.

Protein family/group databases

TCDB3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

PaxDbQ12462.
PeptideAtlasQ12462.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYOL147C; YOL147C; YOL147C.
GeneID854018.
KEGGsce:YOL147C.

Organism-specific databases

SGDS000005507. PEX11.

Phylogenomic databases

eggNOGNOG328843.
HOGENOMHOG000214966.
OMAYLHFTEG.
OrthoDBEOG7XSTRS.

Enzyme and pathway databases

BioCycYEAST:G3O-33537-MONOMER.

Gene expression databases

GenevestigatorQ12462.

Family and domain databases

InterProIPR008733. PEX11.
[Graphical view]
PANTHERPTHR12652. PTHR12652. 1 hit.
PfamPF05648. PEX11. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio975544.

Entry information

Entry namePEX11_YEAST
AccessionPrimary (citable) accession number: Q12462
Secondary accession number(s): D6W1S2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XV

Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families