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Protein

Peroxisomal membrane protein PMP27

Gene

PEX11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in peroxisomal proliferation. Promotes peroxisome division and biogenesis.3 Publications

GO - Biological processi

  1. fatty acid oxidation Source: SGD
  2. peroxisome fission Source: UniProtKB
  3. peroxisome organization Source: UniProtKB
  4. regulation of peroxisome size Source: UniProtKB
  5. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Peroxisome biogenesis

Enzyme and pathway databases

BioCyciYEAST:G3O-33537-MONOMER.
ReactomeiREACT_306517. PPARA activates gene expression.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein PMP27
Alternative name(s):
Peroxin-11
Gene namesi
Name:PEX11
Synonyms:PMP24, PMP27
Ordered Locus Names:YOL147C
ORF Names:O0454
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XV

Organism-specific databases

SGDiS000005507. PEX11.

Subcellular locationi

Peroxisome membrane 2 Publications; Peripheral membrane protein 2 Publications

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. integral component of peroxisomal membrane Source: UniProtKB
  3. peroxisomal importomer complex Source: SGD
  4. peroxisomal membrane Source: SGD
  5. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 236235Peroxisomal membrane protein PMP27PRO_0000105974Add
BLAST

Proteomic databases

MaxQBiQ12462.
PaxDbiQ12462.
PeptideAtlasiQ12462.

Expressioni

Gene expression databases

GenevestigatoriQ12462.

Interactioni

Subunit structurei

Homooligomer. Interacts with PEX34.3 Publications

Protein-protein interaction databases

BioGridi34270. 43 interactions.
DIPiDIP-3839N.
IntActiQ12462. 28 interactions.
MINTiMINT-500737.
STRINGi4932.YOL147C.

Structurei

3D structure databases

ProteinModelPortaliQ12462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-11 family.Curated

Phylogenomic databases

eggNOGiNOG328843.
HOGENOMiHOG000214966.
InParanoidiQ12462.
OMAiYLHFTEG.
OrthoDBiEOG7XSTRS.

Family and domain databases

InterProiIPR008733. PEX11.
[Graphical view]
PfamiPF05648. PEX11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCDTLVYHP SVTRFVKFLD GSAGREKVLR LLQYLARFLA VQNSSLLARQ
60 70 80 90 100
LQAQFTTVRK FLRFLKPLNH LQAAAKFYDN KLASDNVVRV CNVLKNIFFA
110 120 130 140 150
AYLSLDQVNL LRILKVIPVT VLTGKKIPRW SNWCWLFGLL SGLAMDLRKI
160 170 180 190 200
QTSHAQIAAF VKAKSQSQGD EHEDHKKVLG KAYQDRYTAL RRLFWDAADS
210 220 230
FIVLNNLGYL SSNEEYVALS GVVTSILGMQ DMWKAT
Length:236
Mass (Da):26,875
Last modified:January 23, 2007 - v2
Checksum:i26B95896D57018DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48239 Genomic DNA. Translation: CAA88280.1.
Z74889 Genomic DNA. Translation: CAA99168.1.
X81465 Genomic DNA. Translation: CAA57223.1.
Z46846 Genomic DNA. Translation: CAA86903.1.
AY558010 Genomic DNA. Translation: AAS56336.1.
BK006948 Genomic DNA. Translation: DAA10638.1.
PIRiA56509.
RefSeqiNP_014494.1. NM_001183401.1.

Genome annotation databases

EnsemblFungiiYOL147C; YOL147C; YOL147C.
GeneIDi854018.
KEGGisce:YOL147C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48239 Genomic DNA. Translation: CAA88280.1.
Z74889 Genomic DNA. Translation: CAA99168.1.
X81465 Genomic DNA. Translation: CAA57223.1.
Z46846 Genomic DNA. Translation: CAA86903.1.
AY558010 Genomic DNA. Translation: AAS56336.1.
BK006948 Genomic DNA. Translation: DAA10638.1.
PIRiA56509.
RefSeqiNP_014494.1. NM_001183401.1.

3D structure databases

ProteinModelPortaliQ12462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34270. 43 interactions.
DIPiDIP-3839N.
IntActiQ12462. 28 interactions.
MINTiMINT-500737.
STRINGi4932.YOL147C.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.

Proteomic databases

MaxQBiQ12462.
PaxDbiQ12462.
PeptideAtlasiQ12462.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOL147C; YOL147C; YOL147C.
GeneIDi854018.
KEGGisce:YOL147C.

Organism-specific databases

SGDiS000005507. PEX11.

Phylogenomic databases

eggNOGiNOG328843.
HOGENOMiHOG000214966.
InParanoidiQ12462.
OMAiYLHFTEG.
OrthoDBiEOG7XSTRS.

Enzyme and pathway databases

BioCyciYEAST:G3O-33537-MONOMER.
ReactomeiREACT_306517. PPARA activates gene expression.

Miscellaneous databases

NextBioi975544.

Gene expression databases

GenevestigatoriQ12462.

Family and domain databases

InterProiIPR008733. PEX11.
[Graphical view]
PfamiPF05648. PEX11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p."
    Erdmann R., Blobel G.
    J. Cell Biol. 128:509-523(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-28.
    Strain: ATCC 204508 / S288c.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-30 AND 192-207.
    Strain: S288c / GRF88.
  3. "DNA sequence analysis of a 13 kbp fragment of the left arm of yeast chromosome XV containing seven new open reading frames."
    Casamayor A., Aldea M., Casas C., Herrero E., Gamo F.-J., Lafuente M.J., Gancedo C., Arino J.
    Yeast 11:1281-1288(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 96604 / S288c / FY1679.
  4. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast."
    Tower R.J., Fagarasanu A., Aitchison J.D., Rachubinski R.A.
    Mol. Biol. Cell 22:1727-1738(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PEX34.
  6. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  8. "Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae."
    Tam Y.Y.C., Torres-Guzman J.C., Vizeacoumar F.J., Smith J.J., Marelli M., Aitchison J.D., Rachubinski R.A.
    Mol. Biol. Cell 14:4089-4102(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  9. "Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis."
    Rottensteiner H., Stein K., Sonnenhol E., Erdmann R.
    Mol. Biol. Cell 14:4316-4328(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
    Strain: ATCC 201389 / BY4742.
  10. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  11. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEX11_YEAST
AccessioniPrimary (citable) accession number: Q12462
Secondary accession number(s): D6W1S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1630 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.