Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein phosphatase 2A activator 2

Gene

RRD2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg2+ by dissociating the inactive form from the complex. Acts also inhibitory at high concentrations. Involved in the regulation of cell cycle progression, mitotic spindle formation and bud morphogenesis.6 Publications

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: SGD
  • protein phosphatase type 2A regulator activity Source: SGD
  • protein tyrosine phosphatase activator activity Source: GO_Central

GO - Biological processi

  • mitotic spindle organization in nucleus Source: SGD
  • response to osmotic stress Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:G3O-34049-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A activator 2 (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase PTPA-2
Short name:
PPIase PTPA-2
Short name:
Rotamase PTPA-2
Phosphotyrosyl phosphatase activator 2
Gene namesi
Name:RRD2
Synonyms:NOH1, YPA2
Ordered Locus Names:YPL152W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL152W.
SGDiS000006073. RRD2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nucleus Source: GO_Central
  • protein phosphatase type 2A complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002261201 – 358Serine/threonine-protein phosphatase 2A activator 2Add BLAST358

Proteomic databases

MaxQBiQ12461.
PRIDEiQ12461.

Interactioni

Subunit structurei

Interacts with the phosphatase PP2A catalytic subunits PPH21 and PPH22. Forms a ternary complex with PPH21-TAP42.3 Publications

Protein-protein interaction databases

BioGridi36031. 66 interactors.
DIPiDIP-2558N.
IntActiQ12461. 3 interactors.
MINTiMINT-556521.

Structurei

Secondary structure

1358
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni10 – 13Combined sources4
Helixi14 – 17Combined sources4
Helixi20 – 34Combined sources15
Turni35 – 38Combined sources4
Helixi50 – 66Combined sources17
Helixi84 – 103Combined sources20
Helixi109 – 120Combined sources12
Turni126 – 129Combined sources4
Helixi133 – 148Combined sources16
Helixi154 – 163Combined sources10
Helixi165 – 180Combined sources16
Beta strandi192 – 196Combined sources5
Helixi199 – 207Combined sources9
Turni208 – 210Combined sources3
Helixi216 – 220Combined sources5
Helixi222 – 228Combined sources7
Turni229 – 231Combined sources3
Helixi233 – 244Combined sources12
Turni245 – 247Combined sources3
Helixi250 – 253Combined sources4
Helixi255 – 260Combined sources6
Helixi266 – 280Combined sources15
Turni281 – 283Combined sources3
Helixi285 – 288Combined sources4
Beta strandi295 – 297Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IXNX-ray2.80A/B1-304[»]
ProteinModelPortaliQ12461.
SMRiQ12461.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12461.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000011500.
HOGENOMiHOG000205736.
InParanoidiQ12461.
KOiK17605.
OMAiFRTFYDK.
OrthoDBiEOG092C3CMG.

Family and domain databases

CDDicd04087. PTPA. 1 hit.
InterProiIPR004327. Phstyr_phstse_ac.
[Graphical view]
PANTHERiPTHR10012. PTHR10012. 1 hit.
PfamiPF03095. PTPA. 1 hit.
[Graphical view]
PIRSFiPIRSF016325. Phstyr_phstse_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12461-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPEKRLLTP DDMKLWEESP TRAHFTKFII DLAESVKGHE NSQYKEPISE
60 70 80 90 100
SINSMMNLLS QIKDITQKHP VIKDADSSRF GKVEFRDFYD EVSRNSRKIL
110 120 130 140 150
RSEFPSLTDE QLEQLSIYLD ESWGNKRRID YGSGHELNFM CLLYGLYSYG
160 170 180 190 200
IFNLSNDSTN LVLKVFIEYL KIMRILETKY WLEPAGSHGV WGLDDYHFLP
210 220 230 240 250
FLFGAFQLTT HKHLKPISIH NNELVEMFAH RYLYFGCIAF INKVKSSASL
260 270 280 290 300
RWHSPMLDDI SGVKTWSKVA EGMIKMYKAE VLSKLPIMQH FYFSEFLPCP
310 320 330 340 350
DGVSPPRGHI HDGTDKDDEC NFEGHVHTTW GDCCGIKLPS AIAATEMNKK

HHKPIPFD
Length:358
Mass (Da):41,452
Last modified:November 1, 1996 - v1
Checksum:iE0BE8A7EDD54E306
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96770 Genomic DNA. Translation: CAA65569.1.
Z73508 Genomic DNA. Translation: CAA97857.1.
BK006949 Genomic DNA. Translation: DAA11283.1.
PIRiS65163.
RefSeqiNP_015173.1. NM_001183966.1.

Genome annotation databases

EnsemblFungiiYPL152W; YPL152W; YPL152W.
GeneIDi855951.
KEGGisce:YPL152W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96770 Genomic DNA. Translation: CAA65569.1.
Z73508 Genomic DNA. Translation: CAA97857.1.
BK006949 Genomic DNA. Translation: DAA11283.1.
PIRiS65163.
RefSeqiNP_015173.1. NM_001183966.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IXNX-ray2.80A/B1-304[»]
ProteinModelPortaliQ12461.
SMRiQ12461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36031. 66 interactors.
DIPiDIP-2558N.
IntActiQ12461. 3 interactors.
MINTiMINT-556521.

Proteomic databases

MaxQBiQ12461.
PRIDEiQ12461.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL152W; YPL152W; YPL152W.
GeneIDi855951.
KEGGisce:YPL152W.

Organism-specific databases

EuPathDBiFungiDB:YPL152W.
SGDiS000006073. RRD2.

Phylogenomic databases

GeneTreeiENSGT00390000011500.
HOGENOMiHOG000205736.
InParanoidiQ12461.
KOiK17605.
OMAiFRTFYDK.
OrthoDBiEOG092C3CMG.

Enzyme and pathway databases

BioCyciYEAST:G3O-34049-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ12461.
PROiQ12461.

Family and domain databases

CDDicd04087. PTPA. 1 hit.
InterProiIPR004327. Phstyr_phstse_ac.
[Graphical view]
PANTHERiPTHR10012. PTHR10012. 1 hit.
PfamiPF03095. PTPA. 1 hit.
[Graphical view]
PIRSFiPIRSF016325. Phstyr_phstse_ac. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTPA2_YEAST
AccessioniPrimary (citable) accession number: Q12461
Secondary accession number(s): D6W3L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2430 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.