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Protein

Serine/threonine-protein phosphatase 2A activator 2

Gene

RRD2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for TAP42-associated PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg2+ by dissociating the inactive form from the complex. Acts also inhibitory at high concentrations. Involved in the regulation of cell cycle progression, mitotic spindle formation and bud morphogenesis.6 Publications

Miscellaneous

Present with 2430 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: SGD
  • protein phosphatase regulator activity Source: SGD
  • protein tyrosine phosphatase activator activity Source: GO_Central

GO - Biological processi

  • mitotic spindle organization Source: SGD
  • response to osmotic stress Source: SGD

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:G3O-34049-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A activator 2 (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase PTPA-2
Short name:
PPIase PTPA-2
Short name:
Rotamase PTPA-2
Phosphotyrosyl phosphatase activator 2
Gene namesi
Name:RRD2
Synonyms:NOH1, YPA2
Ordered Locus Names:YPL152W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL152W
SGDiS000006073 RRD2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002261201 – 358Serine/threonine-protein phosphatase 2A activator 2Add BLAST358

Proteomic databases

MaxQBiQ12461
PaxDbiQ12461
PRIDEiQ12461

Interactioni

Subunit structurei

Interacts with the phosphatase PP2A catalytic subunits PPH21 and PPH22. Forms a ternary complex with PPH21-TAP42.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPH21P235947EBI-32784,EBI-12745

Protein-protein interaction databases

BioGridi36031, 206 interactors
DIPiDIP-2558N
IntActiQ12461, 4 interactors
MINTiQ12461
STRINGi4932.YPL152W

Structurei

Secondary structure

1358
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni10 – 13Combined sources4
Helixi14 – 17Combined sources4
Helixi20 – 34Combined sources15
Turni35 – 38Combined sources4
Helixi50 – 66Combined sources17
Helixi84 – 103Combined sources20
Helixi109 – 120Combined sources12
Turni126 – 129Combined sources4
Helixi133 – 148Combined sources16
Helixi154 – 163Combined sources10
Helixi165 – 180Combined sources16
Beta strandi192 – 196Combined sources5
Helixi199 – 207Combined sources9
Turni208 – 210Combined sources3
Helixi216 – 220Combined sources5
Helixi222 – 228Combined sources7
Turni229 – 231Combined sources3
Helixi233 – 244Combined sources12
Turni245 – 247Combined sources3
Helixi250 – 253Combined sources4
Helixi255 – 260Combined sources6
Helixi266 – 280Combined sources15
Turni281 – 283Combined sources3
Helixi285 – 288Combined sources4
Beta strandi295 – 297Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IXNX-ray2.80A/B1-304[»]
ProteinModelPortaliQ12461
SMRiQ12461
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12461

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00910000146525
HOGENOMiHOG000205736
InParanoidiQ12461
KOiK17605
OMAiMRRMFVA
OrthoDBiEOG092C3CMG

Family and domain databases

CDDicd04087 PTPA, 1 hit
InterProiView protein in InterPro
IPR004327 Phstyr_phstse_ac
IPR037218 PTPA_sf
PANTHERiPTHR10012 PTHR10012, 1 hit
PfamiView protein in Pfam
PF03095 PTPA, 1 hit
PIRSFiPIRSF016325 Phstyr_phstse_ac, 1 hit
SUPFAMiSSF140984 SSF140984, 1 hit

Sequencei

Sequence statusi: Complete.

Q12461-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPEKRLLTP DDMKLWEESP TRAHFTKFII DLAESVKGHE NSQYKEPISE
60 70 80 90 100
SINSMMNLLS QIKDITQKHP VIKDADSSRF GKVEFRDFYD EVSRNSRKIL
110 120 130 140 150
RSEFPSLTDE QLEQLSIYLD ESWGNKRRID YGSGHELNFM CLLYGLYSYG
160 170 180 190 200
IFNLSNDSTN LVLKVFIEYL KIMRILETKY WLEPAGSHGV WGLDDYHFLP
210 220 230 240 250
FLFGAFQLTT HKHLKPISIH NNELVEMFAH RYLYFGCIAF INKVKSSASL
260 270 280 290 300
RWHSPMLDDI SGVKTWSKVA EGMIKMYKAE VLSKLPIMQH FYFSEFLPCP
310 320 330 340 350
DGVSPPRGHI HDGTDKDDEC NFEGHVHTTW GDCCGIKLPS AIAATEMNKK

HHKPIPFD
Length:358
Mass (Da):41,452
Last modified:November 1, 1996 - v1
Checksum:iE0BE8A7EDD54E306
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96770 Genomic DNA Translation: CAA65569.1
Z73508 Genomic DNA Translation: CAA97857.1
BK006949 Genomic DNA Translation: DAA11283.1
PIRiS65163
RefSeqiNP_015173.1, NM_001183966.1

Genome annotation databases

EnsemblFungiiYPL152W; YPL152W; YPL152W
GeneIDi855951
KEGGisce:YPL152W

Similar proteinsi

Entry informationi

Entry nameiPTPA2_YEAST
AccessioniPrimary (citable) accession number: Q12461
Secondary accession number(s): D6W3L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

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