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Protein

Putative reductase 1

Gene

YPR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 14100 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56Proton donorBy similarity1
Sitei81Lowers pKa of active site TyrBy similarity1
Binding sitei112SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 274NADPBy similarityAdd BLAST55

GO - Molecular functioni

  • alditol:NADP+ 1-oxidoreductase activity Source: SGD
  • carbonyl reductase (NADPH) activity Source: SGD

GO - Biological processi

  • arabinose catabolic process Source: SGD
  • cellular response to oxidative stress Source: SGD
  • D-xylose catabolic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyciYEAST:G3O-29918-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative reductase 1 (EC:1.1.1.-)
Gene namesi
Name:YPR1
Ordered Locus Names:YDR368W
ORF Names:D9481.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR368W
SGDiS000002776 YPR1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001246121 – 312Putative reductase 1Add BLAST312

Proteomic databases

MaxQBiQ12458
PaxDbiQ12458
PRIDEiQ12458

PTM databases

iPTMnetiQ12458

Interactioni

Protein-protein interaction databases

BioGridi32427, 45 interactors
DIPiDIP-4334N
IntActiQ12458, 1 interactor
MINTiQ12458
STRINGi4932.YDR368W

Structurei

3D structure databases

ProteinModelPortaliQ12458
SMRiQ12458
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

GeneTreeiENSGT00850000132445
HOGENOMiHOG000250272
InParanoidiQ12458
OMAiTSKLWLQ
OrthoDBiEOG092C324N

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit
PS00063 ALDOKETO_REDUCTASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q12458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPATLKNSSA TLKLNTGASI PVLGFGTWRS VDNNGYHSVI AALKAGYRHI
60 70 80 90 100
DAAAIYLNEE EVGRAIKDSG VPREEIFITT KLWGTEQRDP EAALNKSLKR
110 120 130 140 150
LGLDYVDLYL MHWPVPLKTD RVTDGNVLCI PTLEDGTVDI DTKEWNFIKT
160 170 180 190 200
WELMQELPKT GKTKAVGVSN FSINNIKELL ESPNNKVVPA TNQIEIHPLL
210 220 230 240 250
PQDELIAFCK EKGIVVEAYS PFGSANAPLL KEQAIIDMAK KHGVEPAQLI
260 270 280 290 300
ISWSIQRGYV VLAKSVNPER IVSNFKIFTL PEDDFKTISN LSKVHGTKRV
310
VDMKWGSFPI FQ
Length:312
Mass (Da):34,755
Last modified:November 1, 1997 - v1
Checksum:i078F92FCACECC70E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80642 Genomic DNA Translation: CAA56686.1
U28373 Genomic DNA Translation: AAB64804.1
BK006938 Genomic DNA Translation: DAA12209.1
PIRiS61163
RefSeqiNP_010656.1, NM_001180676.1

Genome annotation databases

EnsemblFungiiYDR368W; YDR368W; YDR368W
GeneIDi851974
KEGGisce:YDR368W

Similar proteinsi

Entry informationi

Entry nameiYPR1_YEAST
AccessioniPrimary (citable) accession number: Q12458
Secondary accession number(s): D6VSZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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