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Protein

Putative reductase 1

Gene

YPR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56Proton donorBy similarity1
Sitei81Lowers pKa of active site TyrBy similarity1
Binding sitei112SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 274NADPBy similarityAdd BLAST55

GO - Molecular functioni

  • alditol:NADP+ 1-oxidoreductase activity Source: SGD
  • carbonyl reductase (NADPH) activity Source: SGD

GO - Biological processi

  • arabinose catabolic process Source: SGD
  • cellular response to oxidative stress Source: SGD
  • D-xylose catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciYEAST:G3O-29918-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative reductase 1 (EC:1.1.1.-)
Gene namesi
Name:YPR1
Ordered Locus Names:YDR368W
ORF Names:D9481.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR368W.
SGDiS000002776. YPR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001246121 – 312Putative reductase 1Add BLAST312

Proteomic databases

MaxQBiQ12458.
PRIDEiQ12458.

PTM databases

iPTMnetiQ12458.

Interactioni

Protein-protein interaction databases

BioGridi32427. 24 interactors.
DIPiDIP-4334N.
IntActiQ12458. 1 interactor.
MINTiMINT-486642.

Structurei

3D structure databases

ProteinModelPortaliQ12458.
SMRiQ12458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

GeneTreeiENSGT00850000132445.
HOGENOMiHOG000250272.
InParanoidiQ12458.
OMAiYMEELET.
OrthoDBiEOG092C324N.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPATLKNSSA TLKLNTGASI PVLGFGTWRS VDNNGYHSVI AALKAGYRHI
60 70 80 90 100
DAAAIYLNEE EVGRAIKDSG VPREEIFITT KLWGTEQRDP EAALNKSLKR
110 120 130 140 150
LGLDYVDLYL MHWPVPLKTD RVTDGNVLCI PTLEDGTVDI DTKEWNFIKT
160 170 180 190 200
WELMQELPKT GKTKAVGVSN FSINNIKELL ESPNNKVVPA TNQIEIHPLL
210 220 230 240 250
PQDELIAFCK EKGIVVEAYS PFGSANAPLL KEQAIIDMAK KHGVEPAQLI
260 270 280 290 300
ISWSIQRGYV VLAKSVNPER IVSNFKIFTL PEDDFKTISN LSKVHGTKRV
310
VDMKWGSFPI FQ
Length:312
Mass (Da):34,755
Last modified:November 1, 1997 - v1
Checksum:i078F92FCACECC70E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80642 Genomic DNA. Translation: CAA56686.1.
U28373 Genomic DNA. Translation: AAB64804.1.
BK006938 Genomic DNA. Translation: DAA12209.1.
PIRiS61163.
RefSeqiNP_010656.1. NM_001180676.1.

Genome annotation databases

EnsemblFungiiYDR368W; YDR368W; YDR368W.
GeneIDi851974.
KEGGisce:YDR368W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80642 Genomic DNA. Translation: CAA56686.1.
U28373 Genomic DNA. Translation: AAB64804.1.
BK006938 Genomic DNA. Translation: DAA12209.1.
PIRiS61163.
RefSeqiNP_010656.1. NM_001180676.1.

3D structure databases

ProteinModelPortaliQ12458.
SMRiQ12458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32427. 24 interactors.
DIPiDIP-4334N.
IntActiQ12458. 1 interactor.
MINTiMINT-486642.

PTM databases

iPTMnetiQ12458.

Proteomic databases

MaxQBiQ12458.
PRIDEiQ12458.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR368W; YDR368W; YDR368W.
GeneIDi851974.
KEGGisce:YDR368W.

Organism-specific databases

EuPathDBiFungiDB:YDR368W.
SGDiS000002776. YPR1.

Phylogenomic databases

GeneTreeiENSGT00850000132445.
HOGENOMiHOG000250272.
InParanoidiQ12458.
OMAiYMEELET.
OrthoDBiEOG092C324N.

Enzyme and pathway databases

BioCyciYEAST:G3O-29918-MONOMER.

Miscellaneous databases

PROiQ12458.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYPR1_YEAST
AccessioniPrimary (citable) accession number: Q12458
Secondary accession number(s): D6VSZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 14100 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.