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Protein

Putative tyrosine-protein phosphatase OCA6

Gene

OCA6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for replication of Brome mosaic virus (BMV).1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei114Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:G3O-29674-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative tyrosine-protein phosphatase OCA6 (EC:3.1.3.48)
Alternative name(s):
Oxidant-induced cell-cycle arrest protein 6
Gene namesi
Name:OCA6
Ordered Locus Names:YDR067C
ORF Names:D4264
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR067C.
SGDiS000002474. OCA6.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444421 – 224Putative tyrosine-protein phosphatase OCA6Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12454.
PRIDEiQ12454.
TopDownProteomicsiQ12454.

PTM databases

iPTMnetiQ12454.

Interactioni

Protein-protein interaction databases

BioGridi32122. 191 interactors.
DIPiDIP-5466N.
IntActiQ12454. 5 interactors.
MINTiMINT-559882.
STRINGi4932.YDR067C.

Structurei

3D structure databases

ProteinModelPortaliQ12454.
SMRiQ12454.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000248488.
InParanoidiQ12454.
KOiK18046.
OMAiYRGAYPR.
OrthoDBiEOG092C4JKC.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR029021. Prot-tyrosine_phosphatase-like.
IPR004861. Tyr_Pase_SIW14-like.
PfamiView protein in Pfam
PF03162. Y_phosphatase2. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12454-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLVTPLQFS TVQPNLYRGS YPREINLPFL RTLRLKYILS LTPEPLSTDP
60 70 80 90 100
LMVKFCEENN IKTIHIKCQS ERKADKTKPK IKRKKKTVPI EYDVVVRCVK
110 120 130 140 150
FLIDKGHYPC YMHCTNGELI ISLVVACMRK FSYWSTVSIL NEFLVYNSSI
160 170 180 190 200
NIHERNFIEN FNSEIEVDDL DIKDKVPWIT VRYIARTATE SKDELRVDDA
210 220
NASEKVARVS SVSNSLPKLK FHSM
Length:224
Mass (Da):26,024
Last modified:November 1, 1996 - v1
Checksum:iFFF222994B196F86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti208R → G in AAS56817 (PubMed:9169867).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84162 Genomic DNA. Translation: CAA58983.1.
Z49209 Genomic DNA. Translation: CAA89096.1.
Z74363 Genomic DNA. Translation: CAA98885.1.
AY558491 Genomic DNA. Translation: AAS56817.1.
BK006938 Genomic DNA. Translation: DAA11913.1.
PIRiS54051.
RefSeqiNP_010352.1. NM_001180375.1.

Genome annotation databases

EnsemblFungiiYDR067C; YDR067C; YDR067C.
GeneIDi851639.
KEGGisce:YDR067C.

Similar proteinsi

Entry informationi

Entry nameiOCA6_YEAST
AccessioniPrimary (citable) accession number: Q12454
Secondary accession number(s): D6VS53, Q6Q559
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names