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Q12454

- OCA6_YEAST

UniProt

Q12454 - OCA6_YEAST

Protein

Putative tyrosine-protein phosphatase OCA6

Gene

OCA6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Required for replication of Brome mosaic virus (BMV).1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei114 – 1141Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29674-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative tyrosine-protein phosphatase OCA6 (EC:3.1.3.48)
    Alternative name(s):
    Oxidant-induced cell-cycle arrest protein 6
    Gene namesi
    Name:OCA6
    Ordered Locus Names:YDR067C
    ORF Names:D4264
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR067c.
    SGDiS000002474. OCA6.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224Putative tyrosine-protein phosphatase OCA6PRO_0000244442Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ12454.
    PaxDbiQ12454.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12454.

    Interactioni

    Protein-protein interaction databases

    BioGridi32122. 58 interactions.
    DIPiDIP-5466N.
    IntActiQ12454. 2 interactions.
    MINTiMINT-559882.
    STRINGi4932.YDR067C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12454.
    SMRiQ12454. Positions 3-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2365.
    HOGENOMiHOG000248488.
    KOiK18046.
    OMAiYIHCLNG.
    OrthoDBiEOG7J70TB.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR004861. Tyr_Pase_SIW14-like.
    [Graphical view]
    PfamiPF03162. Y_phosphatase2. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q12454-1 [UniParc]FASTAAdd to Basket

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    MTLVTPLQFS TVQPNLYRGS YPREINLPFL RTLRLKYILS LTPEPLSTDP    50
    LMVKFCEENN IKTIHIKCQS ERKADKTKPK IKRKKKTVPI EYDVVVRCVK 100
    FLIDKGHYPC YMHCTNGELI ISLVVACMRK FSYWSTVSIL NEFLVYNSSI 150
    NIHERNFIEN FNSEIEVDDL DIKDKVPWIT VRYIARTATE SKDELRVDDA 200
    NASEKVARVS SVSNSLPKLK FHSM 224
    Length:224
    Mass (Da):26,024
    Last modified:November 1, 1996 - v1
    Checksum:iFFF222994B196F86
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti208 – 2081R → G in AAS56817. (PubMed:9169867)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84162 Genomic DNA. Translation: CAA58983.1.
    Z49209 Genomic DNA. Translation: CAA89096.1.
    Z74363 Genomic DNA. Translation: CAA98885.1.
    AY558491 Genomic DNA. Translation: AAS56817.1.
    BK006938 Genomic DNA. Translation: DAA11913.1.
    PIRiS54051.
    RefSeqiNP_010352.1. NM_001180375.1.

    Genome annotation databases

    EnsemblFungiiYDR067C; YDR067C; YDR067C.
    GeneIDi851639.
    KEGGisce:YDR067C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84162 Genomic DNA. Translation: CAA58983.1 .
    Z49209 Genomic DNA. Translation: CAA89096.1 .
    Z74363 Genomic DNA. Translation: CAA98885.1 .
    AY558491 Genomic DNA. Translation: AAS56817.1 .
    BK006938 Genomic DNA. Translation: DAA11913.1 .
    PIRi S54051.
    RefSeqi NP_010352.1. NM_001180375.1.

    3D structure databases

    ProteinModelPortali Q12454.
    SMRi Q12454. Positions 3-162.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32122. 58 interactions.
    DIPi DIP-5466N.
    IntActi Q12454. 2 interactions.
    MINTi MINT-559882.
    STRINGi 4932.YDR067C.

    Proteomic databases

    MaxQBi Q12454.
    PaxDbi Q12454.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR067C ; YDR067C ; YDR067C .
    GeneIDi 851639.
    KEGGi sce:YDR067C.

    Organism-specific databases

    CYGDi YDR067c.
    SGDi S000002474. OCA6.

    Phylogenomic databases

    eggNOGi COG2365.
    HOGENOMi HOG000248488.
    KOi K18046.
    OMAi YIHCLNG.
    OrthoDBi EOG7J70TB.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29674-MONOMER.

    Miscellaneous databases

    NextBioi 969203.

    Gene expression databases

    Genevestigatori Q12454.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR004861. Tyr_Pase_SIW14-like.
    [Graphical view ]
    Pfami PF03162. Y_phosphatase2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence analysis of a 32,500 bp region of the right arm of Saccharomyces cerevisiae chromosome IV."
      Brandt P., Ramlow S., Otto B., Bloecker H.
      Yeast 12:85-90(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. "Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus."
      Kushner D.B., Lindenbach B.D., Grdzelishvili V.Z., Noueiry A.O., Paul S.M., Ahlquist P.
      Proc. Natl. Acad. Sci. U.S.A. 100:15764-15769(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiOCA6_YEAST
    AccessioniPrimary (citable) accession number: Q12454
    Secondary accession number(s): D6VS53, Q6Q559
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3