Q12450 (ERP4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein ERP4

Gene names

Name:	ERP4
Ordered Locus Names:	YOR016C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in vesicular protein trafficking By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity.
Miscellaneous	Present with 2710 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the EMP24/GP25L family. Contains 1 GOLD domain.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Endoplasmic reticulum Membrane
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ER to Golgi vesicle-mediated transport Inferred from genetic interaction Ref.4. Source: SGD protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from sequence model Ref.4. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ERP1	Q05359	3	EBI-6598,EBI-6581

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 207	186	Protein ERP4		PRO_0000010411
Regions
	Topological domain	22 – 174	153	Lumenal Potential
	Transmembrane	175 – 195	21	Helical; Potential
	Topological domain	196 – 207	12	Cytoplasmic Potential
	Domain	36 – 118	83	GOLD

Sequences

	Sequence		Length	Mass (Da)
	Q12450 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3C8FDC75577690D6	FASTA	207	23,515
	10 20 30 40 50 60 MRVFTLIAIL FSSSLLTHAF SSNYAPVGIS LPAFTKECLY YDLSSDKDVL VVSYQVLTGG 70 80 90 100 110 120 NFEIDFDITA PDGSVIVTER QKKHSDFLLK SFGIGKYTFC LSNNYGTSPK KVEITLEKEK 130 140 150 160 170 180 EIVSSHESKE DIIANNAIEE IDRNLNKITK TMDYLRAREW RNMYTVSSTE SRLTWLSLLI 190 200 MGVMVGISIV QALIIQFFFT SRQKNYV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex." Marzioch M., Henthorn D.C., Herrmann J.M., Wilson R., Thomas D.Y., Bergeron J.J.M., Solari R.C., Rowley A. Mol. Biol. Cell 10:1923-1938(1999) [PubMed] [Europe PMC] [Abstract] Cited for: GENE NAME.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X87331 Genomic DNA. Translation: CAA60765.1. Z74924 Genomic DNA. Translation: CAA99206.1. AY693089 Genomic DNA. Translation: AAT93108.1. BK006948 Genomic DNA. Translation: DAA10798.1.
PIR	S54622.
RefSeq	NP_014659.1. NM_001183435.1.
3D structure databases
ProteinModelPortal	Q12450.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-7868N.
IntAct	Q12450. 15 interactions.
MINT	MINT-1353951.
STRING	4932.YOR016C.
Proteomic databases
PaxDb	Q12450.
PeptideAtlas	Q12450.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YOR016C; YOR016C; YOR016C.
GeneID	854181.
KEGG	sce:YOR016C.
Organism-specific databases
CYGD	YOR016c.
SGD	S000005542. ERP4.
Phylogenomic databases
eggNOG	NOG284261.
GeneTree	ENSGT00670000098921.
HOGENOM	HOG000000781.
KO	K14825.
OrthoDB	EOG4BVW46.
Gene expression databases
Genevestigator	Q12450.
GermOnline	YOR016C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR009038. GOLD. [Graphical view]
Pfam	PF01105. EMP24_GP25L. 1 hit. [Graphical view]
SUPFAM	SSF101576. GOLD. 1 hit.
PROSITE	PS50866. GOLD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	975984.

Entry information

Entry name

ERP4_YEAST

Accession

Primary (citable) accession number: Q12450
Secondary accession number(s): D6W282

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program