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Protein

Polyamine N-acetyltransferase 1

Gene

PAA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acetylates spermine and probably also other polyamines such as putrescine or spermidine. May regulate the levels of polyamines on chromosomal DNA, which would modify chromatin structure and affect transcription or replication. Also able to acetylate arylalkylamines such as tryptamine and serotonin in vitro.2 Publications

Miscellaneous

Present with 8680 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • aralkylamine N-acetyltransferase activity Source: SGD
  • diamine N-acetyltransferase activity Source: SGD

GO - Biological processi

  • chromatin organization Source: SGD

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-29678-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyamine N-acetyltransferase 1 (EC:2.3.1.-)
Alternative name(s):
Arylalkylamine N-acetyltransferase homolog
Short name:
scAANAT
Gene namesi
Name:PAA1
Ordered Locus Names:YDR071C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR071C
SGDiS000002478 PAA1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002458431 – 191Polyamine N-acetyltransferase 1Add BLAST191

Proteomic databases

MaxQBiQ12447
PaxDbiQ12447
PRIDEiQ12447

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32126, 287 interactors
DIPiDIP-1540N
IntActiQ12447, 24 interactors
MINTiQ12447
STRINGi4932.YDR071C

Structurei

3D structure databases

ProteinModelPortaliQ12447
SMRiQ12447
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 179N-acetyltransferasePROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000248485
InParanoidiQ12447
OMAiMAMPENW
OrthoDBiEOG092C5PVX

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q12447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSSTLPL HMYIRPLIIE DLKQILNLES QGFPPNERAS EEIISFRLIN
60 70 80 90 100
CPELCSGLFI REIEGKEVKK ETLIGHIMGT KIPHEYITIE SMGKLQVESS
110 120 130 140 150
NHIGIHSVVI KPEYQKKNLA TLLLTDYIQK LSNQEIGNKI VLIAHEPLIP
160 170 180 190
FYERVGFKII AENTNVAKDK NFAEQKWIDM ERELIKEEYD N
Length:191
Mass (Da):21,947
Last modified:November 1, 1996 - v1
Checksum:i76AAC4EA2926660D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46796 Genomic DNA Translation: CAA86793.1
Z74367 Genomic DNA Translation: CAA98889.1
AY557672 Genomic DNA Translation: AAS55998.1
BK006938 Genomic DNA Translation: DAA11917.1
PIRiS49826
RefSeqiNP_010356.1, NM_001180379.1

Genome annotation databases

EnsemblFungiiYDR071C; YDR071C; YDR071C
GeneIDi851643
KEGGisce:YDR071C

Similar proteinsi

Entry informationi

Entry nameiPAA1_YEAST
AccessioniPrimary (citable) accession number: Q12447
Secondary accession number(s): D6VS57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health