Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proline-rich protein LAS17

Gene

LAS17

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • actin binding Source: SGD

GO - Biological processi

  • actin cortical patch localization Source: SGD
  • actin filament organization Source: SGD
  • actin filament polymerization Source: SGD
  • actin nucleation Source: SGD
  • endocytosis Source: InterPro
  • positive regulation of actin filament bundle assembly Source: SGD
  • positive regulation of Arp2/3 complex-mediated actin nucleation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-33692-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein LAS17
Gene namesi
Name:LAS17
Ordered Locus Names:YOR181W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR181W.
SGDiS000005707. LAS17.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000843611 – 633Proline-rich protein LAS17Add BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei334PhosphothreonineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei588PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12446.
PRIDEiQ12446.

PTM databases

iPTMnetiQ12446.

Interactioni

Subunit structurei

Interacts with KRE6, LSB3, LSB5 and YSC84.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ARC40P383282EBI-10022,EBI-2777
BZZ1P3882214EBI-10022,EBI-3889
END3P390133EBI-10022,EBI-6460
HOF1Q050803EBI-10022,EBI-5412
LSB3P436039EBI-10022,EBI-22980
LSB5P253693EBI-10022,EBI-10218
MYO3P360063EBI-10022,EBI-11670
MYO5Q044397EBI-10022,EBI-11687
PEX13P806672EBI-10022,EBI-13206
PIN3Q064494EBI-10022,EBI-35523
RVS167P3974312EBI-10022,EBI-14500
SHO1P400735EBI-10022,EBI-18140
SLA1P327906EBI-10022,EBI-17313
SLA2P333383EBI-10022,EBI-17323
VRP1P373706EBI-10022,EBI-20502
YSC84P327937EBI-10022,EBI-24460

GO - Molecular functioni

  • actin binding Source: SGD

Protein-protein interaction databases

BioGridi34576. 155 interactors.
DIPiDIP-963N.
IntActiQ12446. 38 interactors.
MINTiMINT-370148.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZUKX-ray1.90C350-360[»]
ProteinModelPortaliQ12446.
SMRiQ12446.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12446.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 127WH1PROSITE-ProRule annotationAdd BLAST112
Domaini547 – 567WH2PROSITE-ProRule annotationAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi185 – 529Pro-richAdd BLAST345
Compositional biasi185 – 190Poly-Pro6
Compositional biasi323 – 329Poly-Pro7
Compositional biasi342 – 348Poly-Pro7
Compositional biasi352 – 358Poly-Pro7
Compositional biasi385 – 391Poly-Pro7
Compositional biasi427 – 431Poly-Pro5
Compositional biasi470 – 474Poly-Pro5
Compositional biasi503 – 507Poly-Pro5
Compositional biasi520 – 526Poly-Pro7

Sequence similaritiesi

Contains 1 WH1 domain.PROSITE-ProRule annotation
Contains 1 WH2 domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00730000110895.
HOGENOMiHOG000111174.
InParanoidiQ12446.
KOiK05747.
OMAiHISHIGY.
OrthoDBiEOG092C4YPO.

Family and domain databases

CDDicd01205. EVH1_WASP-like. 1 hit.
Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR033927. WASPfam_EVH1.
IPR000697. WH1/EVH1_dom.
IPR003124. WH2_dom.
IPR028297. Wsp1/Las17.
[Graphical view]
PANTHERiPTHR23202:SF34. PTHR23202:SF34. 4 hits.
PfamiPF00568. WH1. 1 hit.
PF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50229. WH1. 1 hit.
PS51082. WH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLNSSDKE IIKRALPKAS NKIIDVTVAR LYIAYPDKNE WQYTGLSGAL
60 70 80 90 100
ALVDDLVGNT FFLKLVDING HRGVIWDQEL YVNFEYYQDR TFFHTFEMEE
110 120 130 140 150
CFAGLLFVDI NEASHFLKRV QKRERYANRK TLLNKNAVAL TKKVREEQKS
160 170 180 190 200
QVVHGPRGES LIDNQRKRYN YEDVDTIPTT KHKAPPPPPP TAETFDSDQT
210 220 230 240 250
SSFSDINSTT ASAPTTPAPA LPPASPEVRK EETHPKHSLP PLPNQFAPLP
260 270 280 290 300
DPPQHNSPPQ NNAPSQPQSN PFPFPIPEIP STQSATNPFP FPVPQQQFNQ
310 320 330 340 350
APSMGIPQQN RPLPQLPNRN NRPVPPPPPM RTTTEGSGVR LPAPPPPPRR
360 370 380 390 400
GPAPPPPPHR HVTSNTLNSA GGNSLLPQAT GRRGPAPPPP PRASRPTPNV
410 420 430 440 450
TMQQNPQQYN NSNRPFGYQT NSNMSSPPPP PVTTFNTLTP QMTAATGQPA
460 470 480 490 500
VPLPQNTQAP SQATNVPVAP PPPPASLGQS QIPQSAPSAP IPPTLPSTTS
510 520 530 540 550
AAPPPPPAFL TQQPQSGGAP APPPPPQMPA TSTSGGGSFA ETTGDAGRDA
560 570 580 590 600
LLASIRGAGG IGALRKVDKS QLDKPSVLLQ EARGESASPP AAAGNGGTPG
610 620 630
GPPASLADAL AAALNKRKTK VGAHDDMDNG DDW
Length:633
Mass (Da):67,572
Last modified:November 1, 1997 - v1
Checksum:i4488355563AA2645
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78487 Genomic DNA. Translation: BAA11386.1.
Z75089 Genomic DNA. Translation: CAA99390.1.
BK006948 Genomic DNA. Translation: DAA10953.1.
PIRiS62057.
RefSeqiNP_014824.1. NM_001183600.1.

Genome annotation databases

EnsemblFungiiYOR181W; YOR181W; YOR181W.
GeneIDi854353.
KEGGisce:YOR181W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78487 Genomic DNA. Translation: BAA11386.1.
Z75089 Genomic DNA. Translation: CAA99390.1.
BK006948 Genomic DNA. Translation: DAA10953.1.
PIRiS62057.
RefSeqiNP_014824.1. NM_001183600.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZUKX-ray1.90C350-360[»]
ProteinModelPortaliQ12446.
SMRiQ12446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34576. 155 interactors.
DIPiDIP-963N.
IntActiQ12446. 38 interactors.
MINTiMINT-370148.

PTM databases

iPTMnetiQ12446.

Proteomic databases

MaxQBiQ12446.
PRIDEiQ12446.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR181W; YOR181W; YOR181W.
GeneIDi854353.
KEGGisce:YOR181W.

Organism-specific databases

EuPathDBiFungiDB:YOR181W.
SGDiS000005707. LAS17.

Phylogenomic databases

GeneTreeiENSGT00730000110895.
HOGENOMiHOG000111174.
InParanoidiQ12446.
KOiK05747.
OMAiHISHIGY.
OrthoDBiEOG092C4YPO.

Enzyme and pathway databases

BioCyciYEAST:G3O-33692-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ12446.
PROiQ12446.

Family and domain databases

CDDicd01205. EVH1_WASP-like. 1 hit.
Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR033927. WASPfam_EVH1.
IPR000697. WH1/EVH1_dom.
IPR003124. WH2_dom.
IPR028297. Wsp1/Las17.
[Graphical view]
PANTHERiPTHR23202:SF34. PTHR23202:SF34. 4 hits.
PfamiPF00568. WH1. 1 hit.
PF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00461. WH1. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50229. WH1. 1 hit.
PS51082. WH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAS17_YEAST
AccessioniPrimary (citable) accession number: Q12446
Secondary accession number(s): D6W2N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8580 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.