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Protein

Nucleoporin POM34

Gene

POM34

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.

GO - Molecular functioni

  • structural constituent of nuclear pore Source: SGD

GO - Biological processi

  • mRNA transport Source: UniProtKB-KW
  • nuclear pore organization Source: SGD
  • nucleocytoplasmic transport Source: SGD
  • protein import into nucleus Source: SGD
  • spindle pole body duplication Source: SGD

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32179-MONOMER

Protein family/group databases

TCDBi1.I.1.1.1 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin POM34
Alternative name(s):
Nuclear pore protein POM34
Pore membrane protein POM34
Gene namesi
Name:POM34
Ordered Locus Names:YLR018C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR018C
SGDiS000004008 POM34

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002049111 – 299Nucleoporin POM34Add BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270PhosphoserineCombined sources1
Modified residuei273PhosphothreonineCombined sources1
Modified residuei292PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12445
PaxDbiQ12445
PRIDEiQ12445

PTM databases

iPTMnetiQ12445

Interactioni

Subunit structurei

The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. The 55-60 MDa NPC is composed of at least 31 different subunits: ASM4, CDC31, GLE1, GLE2, NDC1, NIC96, NSP1, NUP1, NUP2, NUP100, NUP116, NUP120, NUP133, NUP145, NUP157, NUP159, NUP170, NUP188, NUP192, NUP42, NUP49, NUP53, NUP57, NUP60, NUP82, NUP84, NUP85, POM152, POM34, SEC13 and SEH1. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.

Protein-protein interaction databases

BioGridi31292, 165 interactors
DIPiDIP-8961N
IntActiQ12445, 6 interactors
MINTiQ12445
STRINGi4932.YLR018C

Structurei

3D structure databases

ProteinModelPortaliQ12445
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ12445
KOiK18724
OMAiSSKYAYM
OrthoDBiEOG092C5OW8

Family and domain databases

InterProiView protein in InterPro
IPR012578 Nucl_pore_cmplx
PANTHERiPTHR28003 PTHR28003, 1 hit
PfamiView protein in Pfam
PF08058 NPCC, 1 hit

Sequencei

Sequence statusi: Complete.

Q12445-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIQAGQLGL DDNDVPGPLP DTDSKPSSQS QNDTPMFKLG NFESPVLKEL
60 70 80 90 100
SRRTVNKEME TQRIMTNVIA FAFWNLLVKF IKFFWNNTHV GRQFCNRLSR
110 120 130 140 150
IHLYMLTFHT LKKANIIYHT TFSWLNAELL DYLFHLLISL NILFSLWKLL
160 170 180 190 200
STVKVSDLNL TDRQKKLLGV DMQSSVDTGL QPQHPHYVST SKISQMAQNK
210 220 230 240 250
THIPQTNLKN HPAYLFKGLE TPLKARQREM AEEQTKLQSQ SLHTKNVFGT
260 270 280 290
LQRHSGISST LVSANNDNNS PHTPVTRKGY IPSSKYAYMM NSQSPRGKI
Length:299
Mass (Da):34,232
Last modified:November 1, 1996 - v1
Checksum:iEEDB5BEFF5BEDF6A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191S → P in AAS56272 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90564 Genomic DNA Translation: CAA62155.1
Z73191 Genomic DNA Translation: CAA97542.1
Z73190 Genomic DNA Translation: CAA97540.1
AY557946 Genomic DNA Translation: AAS56272.1
BK006945 Genomic DNA Translation: DAA09336.1
PIRiS64840
RefSeqiNP_013118.1, NM_001181905.1

Genome annotation databases

EnsemblFungiiYLR018C; YLR018C; YLR018C
GeneIDi850705
KEGGisce:YLR018C

Similar proteinsi

Entry informationi

Entry nameiPOM34_YEAST
AccessioniPrimary (citable) accession number: Q12445
Secondary accession number(s): D6VY20, E9P8U3, Q7LGY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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