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Protein

Monothiol glutaredoxin-6

Gene

GRX6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 1643 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi136Iron-sulfur (2Fe-2S); shared with dimeric partnerSequence analysis1

GO - Molecular functioni

  • 2 iron, 2 sulfur cluster binding Source: SGD
  • electron transfer activity Source: InterPro
  • glutathione-disulfide reductase activity Source: SGD
  • iron ion binding Source: SGD
  • protein disulfide oxidoreductase activity Source: InterPro
  • protein homodimerization activity Source: SGD

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • cellular response to oxidative stress Source: SGD

Keywordsi

Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29441-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Monothiol glutaredoxin-6
Gene namesi
Name:GRX6
Ordered Locus Names:YDL010W
ORF Names:D2890
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL010W
SGDiS000002168 GRX6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000004298830 – 231Monothiol glutaredoxin-6Add BLAST202

Proteomic databases

MaxQBiQ12438
PaxDbiQ12438
PRIDEiQ12438

PTM databases

iPTMnetiQ12438

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: SGD

Protein-protein interaction databases

BioGridi32043, 48 interactors
STRINGi4932.YDL010W

Structurei

Secondary structure

1231
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi115 – 123Combined sources9
Beta strandi127 – 132Combined sources6
Helixi137 – 149Combined sources13
Beta strandi150 – 154Combined sources5
Beta strandi157 – 160Combined sources4
Helixi161 – 163Combined sources3
Helixi167 – 178Combined sources12
Beta strandi185 – 188Combined sources4
Helixi196 – 204Combined sources9
Helixi208 – 214Combined sources7
Beta strandi221 – 224Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L4NX-ray1.50A113-231[»]
5J3RX-ray2.46A37-231[»]
ProteinModelPortaliQ12438
SMRiQ12438
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ12438

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 219GlutaredoxinPROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00550000075735
HOGENOMiHOG000208731
InParanoidiQ12438
OMAiMMALHES
OrthoDBiEOG092C3ZJC

Family and domain databases

InterProiView protein in InterPro
IPR002109 Glutaredoxin
IPR011899 Glutaredoxin_euk/vir
IPR014025 Glutaredoxin_subgr
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PRINTSiPR00160 GLUTAREDOXIN
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02180 GRX_euk, 1 hit
PROSITEiView protein in PROSITE
PS51354 GLUTAREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPSNKRNAR ILSITTLLLL LVFFVAQNAN FLTVEIKEET SKAFSTNMDN
60 70 80 90 100
MAGGSSREYA AMPTSTTNKG SSEVDEEINE IKQKVGLQQP IASVDDSLSA
110 120 130 140 150
IKNDKGSRIT KAFNVQKEYS LILDLSPIII FSKSTCSYSK GMKELLENEY
160 170 180 190 200
QFIPNYYIIE LDKHGHGEEL QEYIKLVTGR GTVPNLLVNG VSRGGNEEIK
210 220 230
KLHTQGKLLE SLQVWSDGKF SVEQREKPSN N
Length:231
Mass (Da):25,783
Last modified:November 1, 1996 - v1
Checksum:iC76DD4E2A6E16744
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48432 Genomic DNA Translation: CAA88349.1
Z74059 Genomic DNA Translation: CAA98567.1
BK006938 Genomic DNA Translation: DAA11838.1
PIRiS52509
RefSeqiNP_010274.1, NM_001180069.1

Genome annotation databases

EnsemblFungiiYDL010W; YDL010W; YDL010W
GeneIDi851551
KEGGisce:YDL010W

Similar proteinsi

Entry informationi

Entry nameiGLRX6_YEAST
AccessioniPrimary (citable) accession number: Q12438
Secondary accession number(s): D6VRX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health