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Q12433

- AHC1_YEAST

UniProt

Q12433 - AHC1_YEAST

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Protein

Protein AHC1

Gene

AHC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Functions as component of the transcription regulatory histone acetylation (HAT) complex ADA. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B. AHC1 is required for the overall structural integrity of the ADA complex.3 Publications

GO - Biological processi

  1. histone acetylation Source: SGD
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-33571-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AHC1
Alternative name(s):
ADA HAT complex component 1
Gene namesi
Name:AHC1
Ordered Locus Names:YOR023C
ORF Names:OR26.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XV

Organism-specific databases

CYGDiYOR023c.
SGDiS000005549. AHC1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. Ada2/Gcn5/Ada3 transcription activator complex Source: SGD
  2. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Protein AHC1PRO_0000227804Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei282 – 2821Phosphoserine1 Publication
Modified residuei505 – 5051Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12433.
PaxDbiQ12433.

Expressioni

Gene expression databases

GenevestigatoriQ12433.

Interactioni

Subunit structurei

Component of the 0.8 MDa ADA complex, which at least consists of ADA2, ADA3, AHC1 and GCN5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
AHC2P256496EBI-33947,EBI-21993

Protein-protein interaction databases

BioGridi34427. 77 interactions.
DIPiDIP-896N.
IntActiQ12433. 7 interactions.
MINTiMINT-391720.
STRINGi4932.YOR023C.

Structurei

3D structure databases

ProteinModelPortaliQ12433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG40866.
HOGENOMiHOG000033862.
InParanoidiQ12433.
KOiK11370.
OMAiYHTRSKS.
OrthoDBiEOG7VB2QG.

Family and domain databases

InterProiIPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12433-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMSPAQDKLQ HQHHNPNSSS SSSSKMTNVY QVTTPKSPQD LENNMDEPFK
60 70 80 90 100
MDTATSNPDK DSENTQRLKY ECAKGEIQNV LNLHIMLNHK HVRHLRRNVQ
110 120 130 140 150
KVNAKLALLE TLHKDTGLLN KIERTYQLKI KQHQQHSVLG GHFHDSTATE
160 170 180 190 200
NTNASNYNLS YPVLSDYNIN CQPLSSSSNR NLSTTRIPHH HYHTRSKSNG
210 220 230 240 250
LLLEPSALRP ANSNIIDYRL TGSKSLSEAI TKPTPVSLPH SNSDGISSPR
260 270 280 290 300
SSSISPLDEQ PGFQILPFKP SQMHLNHRRN YSSTCLTSNS GIIGKTENNE
310 320 330 340 350
PIFRRYDGIL VIITCSKCDR SGFTSAQGIV NHTRLKHSKL YSSQPLAVLN
360 370 380 390 400
NQKLLPNDKQ DPEILSKFKK LNLDPNKDYL PSDIAIPKPQ SPINHSENHT
410 420 430 440 450
RAPKTVKNTP HLEKLYQNKE DFKKLIDMVN ETPDDLNEYL KQREIQLRYQ
460 470 480 490 500
KEQEEESSKS DDEASYVPSP SLSATATTTT TTDPPSPPVL SSSLQRKLLR
510 520 530 540 550
KRKLSLNSST PMEDLPLRER LRANPTDKKP RKAALLTNEL EGPDPAAKSS
560
SYYNLRSKSR LRGSHT
Length:566
Mass (Da):63,869
Last modified:November 1, 1996 - v1
Checksum:iC18AFA10E4334764
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74931 Genomic DNA. Translation: CAA99213.1.
X87331 Genomic DNA. Translation: CAA60772.1.
BK006948 Genomic DNA. Translation: DAA10806.1.
PIRiS54629.
RefSeqiNP_014666.1. NM_001183442.1.

Genome annotation databases

EnsemblFungiiYOR023C; YOR023C; YOR023C.
GeneIDi854188.
KEGGisce:YOR023C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z74931 Genomic DNA. Translation: CAA99213.1 .
X87331 Genomic DNA. Translation: CAA60772.1 .
BK006948 Genomic DNA. Translation: DAA10806.1 .
PIRi S54629.
RefSeqi NP_014666.1. NM_001183442.1.

3D structure databases

ProteinModelPortali Q12433.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34427. 77 interactions.
DIPi DIP-896N.
IntActi Q12433. 7 interactions.
MINTi MINT-391720.
STRINGi 4932.YOR023C.

Proteomic databases

MaxQBi Q12433.
PaxDbi Q12433.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YOR023C ; YOR023C ; YOR023C .
GeneIDi 854188.
KEGGi sce:YOR023C.

Organism-specific databases

CYGDi YOR023c.
SGDi S000005549. AHC1.

Phylogenomic databases

eggNOGi NOG40866.
HOGENOMi HOG000033862.
InParanoidi Q12433.
KOi K11370.
OMAi YHTRSKS.
OrthoDBi EOG7VB2QG.

Enzyme and pathway databases

BioCyci YEAST:G3O-33571-MONOMER.

Miscellaneous databases

NextBioi 976005.

Gene expression databases

Genevestigatori Q12433.

Family and domain databases

InterProi IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
    Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
    , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
    Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex."
    Grant P.A., Duggan L., Cote J., Roberts S.M., Brownell J.E., Candau R., Ohba R., Owen-Hughes T., Allis C.D., Winston F., Berger S.L., Workman J.L.
    Genes Dev. 11:1640-1650(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE ADA COMPLEX.
  4. "The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae."
    Eberharter A., Sterner D.E., Schieltz D., Hassan A., Yates J.R. III, Berger S.L., Workman J.L.
    Mol. Cell. Biol. 19:6621-6631(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE ADA COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Expanded lysine acetylation specificity of Gcn5 in native complexes."
    Grant P.A., Eberharter A., John S., Cook R.G., Turner B.M., Workman J.L.
    J. Biol. Chem. 274:5895-5900(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE ADA COMPLEX.
  6. "A Gal4-sigma 54 hybrid protein that functions as a potent activator of RNA polymerase II transcription in yeast."
    Chen B.-S., Sun Z.-W., Hampsey M.
    J. Biol. Chem. 276:23881-23887(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
    Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
    Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-505, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-505, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282 AND SER-505, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAHC1_YEAST
AccessioniPrimary (citable) accession number: Q12433
Secondary accession number(s): D6W290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

External Data

Dasty 3