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Q12433

- AHC1_YEAST

UniProt

Q12433 - AHC1_YEAST

Protein

Protein AHC1

Gene

AHC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Functions as component of the transcription regulatory histone acetylation (HAT) complex ADA. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B. AHC1 is required for the overall structural integrity of the ADA complex.3 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. histone acetylation Source: SGD
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33571-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein AHC1
    Alternative name(s):
    ADA HAT complex component 1
    Gene namesi
    Name:AHC1
    Ordered Locus Names:YOR023C
    ORF Names:OR26.13
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR023c.
    SGDiS000005549. AHC1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. Ada2/Gcn5/Ada3 transcription activator complex Source: SGD
    2. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566Protein AHC1PRO_0000227804Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei282 – 2821Phosphoserine1 Publication
    Modified residuei505 – 5051Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ12433.
    PaxDbiQ12433.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12433.

    Interactioni

    Subunit structurei

    Component of the 0.8 MDa ADA complex, which at least consists of ADA2, ADA3, AHC1 and GCN5.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AHC2P256496EBI-33947,EBI-21993

    Protein-protein interaction databases

    BioGridi34427. 76 interactions.
    DIPiDIP-896N.
    IntActiQ12433. 7 interactions.
    MINTiMINT-391720.
    STRINGi4932.YOR023C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12433.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG40866.
    HOGENOMiHOG000033862.
    KOiK11370.
    OMAiYHTRSKS.
    OrthoDBiEOG7VB2QG.

    Family and domain databases

    InterProiIPR015880. Znf_C2H2-like.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12433-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMSPAQDKLQ HQHHNPNSSS SSSSKMTNVY QVTTPKSPQD LENNMDEPFK    50
    MDTATSNPDK DSENTQRLKY ECAKGEIQNV LNLHIMLNHK HVRHLRRNVQ 100
    KVNAKLALLE TLHKDTGLLN KIERTYQLKI KQHQQHSVLG GHFHDSTATE 150
    NTNASNYNLS YPVLSDYNIN CQPLSSSSNR NLSTTRIPHH HYHTRSKSNG 200
    LLLEPSALRP ANSNIIDYRL TGSKSLSEAI TKPTPVSLPH SNSDGISSPR 250
    SSSISPLDEQ PGFQILPFKP SQMHLNHRRN YSSTCLTSNS GIIGKTENNE 300
    PIFRRYDGIL VIITCSKCDR SGFTSAQGIV NHTRLKHSKL YSSQPLAVLN 350
    NQKLLPNDKQ DPEILSKFKK LNLDPNKDYL PSDIAIPKPQ SPINHSENHT 400
    RAPKTVKNTP HLEKLYQNKE DFKKLIDMVN ETPDDLNEYL KQREIQLRYQ 450
    KEQEEESSKS DDEASYVPSP SLSATATTTT TTDPPSPPVL SSSLQRKLLR 500
    KRKLSLNSST PMEDLPLRER LRANPTDKKP RKAALLTNEL EGPDPAAKSS 550
    SYYNLRSKSR LRGSHT 566
    Length:566
    Mass (Da):63,869
    Last modified:November 1, 1996 - v1
    Checksum:iC18AFA10E4334764
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z74931 Genomic DNA. Translation: CAA99213.1.
    X87331 Genomic DNA. Translation: CAA60772.1.
    BK006948 Genomic DNA. Translation: DAA10806.1.
    PIRiS54629.
    RefSeqiNP_014666.1. NM_001183442.1.

    Genome annotation databases

    EnsemblFungiiYOR023C; YOR023C; YOR023C.
    GeneIDi854188.
    KEGGisce:YOR023C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z74931 Genomic DNA. Translation: CAA99213.1 .
    X87331 Genomic DNA. Translation: CAA60772.1 .
    BK006948 Genomic DNA. Translation: DAA10806.1 .
    PIRi S54629.
    RefSeqi NP_014666.1. NM_001183442.1.

    3D structure databases

    ProteinModelPortali Q12433.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34427. 76 interactions.
    DIPi DIP-896N.
    IntActi Q12433. 7 interactions.
    MINTi MINT-391720.
    STRINGi 4932.YOR023C.

    Proteomic databases

    MaxQBi Q12433.
    PaxDbi Q12433.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR023C ; YOR023C ; YOR023C .
    GeneIDi 854188.
    KEGGi sce:YOR023C.

    Organism-specific databases

    CYGDi YOR023c.
    SGDi S000005549. AHC1.

    Phylogenomic databases

    eggNOGi NOG40866.
    HOGENOMi HOG000033862.
    KOi K11370.
    OMAi YHTRSKS.
    OrthoDBi EOG7VB2QG.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33571-MONOMER.

    Miscellaneous databases

    NextBioi 976005.

    Gene expression databases

    Genevestigatori Q12433.

    Family and domain databases

    InterProi IPR015880. Znf_C2H2-like.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex."
      Grant P.A., Duggan L., Cote J., Roberts S.M., Brownell J.E., Candau R., Ohba R., Owen-Hughes T., Allis C.D., Winston F., Berger S.L., Workman J.L.
      Genes Dev. 11:1640-1650(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE ADA COMPLEX.
    4. "The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae."
      Eberharter A., Sterner D.E., Schieltz D., Hassan A., Yates J.R. III, Berger S.L., Workman J.L.
      Mol. Cell. Biol. 19:6621-6631(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE ADA COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    5. "Expanded lysine acetylation specificity of Gcn5 in native complexes."
      Grant P.A., Eberharter A., John S., Cook R.G., Turner B.M., Workman J.L.
      J. Biol. Chem. 274:5895-5900(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE ADA COMPLEX.
    6. "A Gal4-sigma 54 hybrid protein that functions as a potent activator of RNA polymerase II transcription in yeast."
      Chen B.-S., Sun Z.-W., Hampsey M.
      J. Biol. Chem. 276:23881-23887(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-505, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-505, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282 AND SER-505, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAHC1_YEAST
    AccessioniPrimary (citable) accession number: Q12433
    Secondary accession number(s): D6W290
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 339 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3