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Q12428

- PRPD_YEAST

UniProt

Q12428 - PRPD_YEAST

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Protein
Probable 2-methylcitrate dehydratase
Gene
PDH1, YPR002W, LPZ2W, YP9723.02
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the dehydration of 2-methylcitrate to 2-methyl-cis-aconitate By similarity.

Catalytic activityi

(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.

Cofactori

Binds 1 2Fe-2S cluster By similarity.

Pathwayi

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 2-methylcitrate dehydratase activity Source: SGD
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. propionate catabolic process, 2-methylcitrate cycle Source: SGD
  2. propionate metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34164-MONOMER.
UniPathwayiUPA00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-methylcitrate dehydratase (EC:4.2.1.79)
Gene namesi
Name:PDH1
Ordered Locus Names:YPR002W
ORF Names:LPZ2W, YP9723.02
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR002w.
SGDiS000006206. PDH1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Probable 2-methylcitrate dehydratase
PRO_0000215027Add
BLAST

Proteomic databases

MaxQBiQ12428.
PaxDbiQ12428.
PeptideAtlasiQ12428.

Expressioni

Gene expression databases

GenevestigatoriQ12428.

Interactioni

Protein-protein interaction databases

BioGridi36178. 14 interactions.
IntActiQ12428. 1 interaction.
MINTiMINT-2784533.
STRINGi4932.YPR002W.

Structurei

3D structure databases

ProteinModelPortaliQ12428.
SMRiQ12428. Positions 38-513.

Family & Domainsi

Sequence similaritiesi

Belongs to the PrpD family.

Phylogenomic databases

eggNOGiCOG2079.
HOGENOMiHOG000159916.
KOiK01720.
OMAiFRREEGI.
OrthoDBiEOG773XR2.

Family and domain databases

InterProiIPR012705. 2Me_IsoCit_deHydtase_PrpD.
IPR005656. MmgE_PrpD.
[Graphical view]
PANTHERiPTHR16943. PTHR16943. 1 hit.
PfamiPF03972. MmgE_PrpD. 1 hit.
[Graphical view]
SUPFAMiSSF103378. SSF103378. 1 hit.
TIGRFAMsiTIGR02330. prpD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12428-1 [UniParc]FASTAAdd to Basket

« Hide

MFLAKNLKNN KIKVCLPKKK FAALSTASIQ TNERPNPDKV LKDIAKYVHE    50
TPLKSSLALD TARLCFLDTL GCGLAALKFK QAQNIIKPIV PGTIVPSGTK 100
ILGTSYVMDP VKGAFAIGTL IRWLDYNDCW LAAEWGHPSD NLGGILAVAD 150
HLSRLNKATH GKNGKQFLVK DVLEAMIKAH EIQGIIALEN SFNKVGLDHV 200
VLVKVATAGV VSKMLGLSQE QTIEALSQAF VDGQSLRTYR HAPNTGSRKS 250
WAAGDAVSRA VNLAYLVKNA NVGTIPSVLT ARTWGFYDVL FKGKPFSFQQ 300
RSKYDSYVME NVLFKISFPA EFHAQTAVEA AVKAYRILAK QGKTFKDIKS 350
IRIRTQEAAM RIIDKSGPLY NYADRDHCIQ YMIAVPLITG NLTATDYSDE 400
VARNPEIDNL RSKMYCIEDT HLTQNYHDPD KRSIGNALLI ELNDGTQLDE 450
IFVEYPVGHK FRREEGIPLL MNKFQRHLRE HFVESPDKVD LIMKVSSKTN 500
FLNMQIDKYM DLFTEG 516
Length:516
Mass (Da):57,684
Last modified:November 1, 1996 - v1
Checksum:i2ED7F1AF648F2AAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71255 Genomic DNA. Translation: CAA95042.1.
Z48951 Genomic DNA. Translation: CAA88780.1.
U31900 Genomic DNA. Translation: AAA97581.1.
BK006949 Genomic DNA. Translation: DAA11429.1.
PIRiS52815.
RefSeqiNP_015326.1. NM_001184099.1.

Genome annotation databases

EnsemblFungiiYPR002W; YPR002W; YPR002W.
GeneIDi856108.
KEGGisce:YPR002W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z71255 Genomic DNA. Translation: CAA95042.1 .
Z48951 Genomic DNA. Translation: CAA88780.1 .
U31900 Genomic DNA. Translation: AAA97581.1 .
BK006949 Genomic DNA. Translation: DAA11429.1 .
PIRi S52815.
RefSeqi NP_015326.1. NM_001184099.1.

3D structure databases

ProteinModelPortali Q12428.
SMRi Q12428. Positions 38-513.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36178. 14 interactions.
IntActi Q12428. 1 interaction.
MINTi MINT-2784533.
STRINGi 4932.YPR002W.

Proteomic databases

MaxQBi Q12428.
PaxDbi Q12428.
PeptideAtlasi Q12428.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR002W ; YPR002W ; YPR002W .
GeneIDi 856108.
KEGGi sce:YPR002W.

Organism-specific databases

CYGDi YPR002w.
SGDi S000006206. PDH1.

Phylogenomic databases

eggNOGi COG2079.
HOGENOMi HOG000159916.
KOi K01720.
OMAi FRREEGI.
OrthoDBi EOG773XR2.

Enzyme and pathway databases

UniPathwayi UPA00946 .
BioCyci YEAST:G3O-34164-MONOMER.

Miscellaneous databases

NextBioi 981170.
PROi Q12428.

Gene expression databases

Genevestigatori Q12428.

Family and domain databases

InterProi IPR012705. 2Me_IsoCit_deHydtase_PrpD.
IPR005656. MmgE_PrpD.
[Graphical view ]
PANTHERi PTHR16943. PTHR16943. 1 hit.
Pfami PF03972. MmgE_PrpD. 1 hit.
[Graphical view ]
SUPFAMi SSF103378. SSF103378. 1 hit.
TIGRFAMsi TIGR02330. prpD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPRPD_YEAST
AccessioniPrimary (citable) accession number: Q12428
Secondary accession number(s): D6W413
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2730 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

Similar proteinsi