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Protein

Probable 2-methylcitrate dehydratase

Gene

PDH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the stereospecific dehydration of (2S,3S)-2-methylcitrate (2-MC) to yield the cis isomer of 2-methyl-aconitate.By similarity

Miscellaneous

Present with 2730 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O.By similarity

Pathwayi: propanoate degradation

This protein is involved in the pathway propanoate degradation, which is part of Organic acid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway propanoate degradation and in Organic acid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciYEAST:G3O-34164-MONOMER
UniPathwayiUPA00946

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-methylcitrate dehydrataseBy similarity (EC:4.2.1.79By similarity)
Short name:
2-MC dehydrataseBy similarity
Alternative name(s):
(2S,3S)-2-methylcitrate dehydrataseBy similarity
Gene namesi
Name:PDH1
Ordered Locus Names:YPR002W
ORF Names:LPZ2W, YP9723.02
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR002W
SGDiS000006206 PDH1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150271 – 516Probable 2-methylcitrate dehydrataseAdd BLAST516

Proteomic databases

MaxQBiQ12428
PaxDbiQ12428
PRIDEiQ12428

Interactioni

Protein-protein interaction databases

BioGridi3617832 interactors.
IntActiQ12428 8 interactors.
MINTiQ12428
STRINGi4932.YPR002W

Structurei

3D structure databases

ProteinModelPortaliQ12428
SMRiQ12428
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PrpD family.Curated

Phylogenomic databases

HOGENOMiHOG000159916
InParanoidiQ12428
KOiK01720
OMAiECTKHLG
OrthoDBiEOG092C27P8

Family and domain databases

InterProiView protein in InterPro
IPR012705 2Me_IsoCit_deHydtase_PrpD
IPR036148 MmgE/PrpD_sf
IPR005656 MmgE_PrpD
PANTHERiPTHR16943 PTHR16943, 1 hit
PfamiView protein in Pfam
PF03972 MmgE_PrpD, 1 hit
SUPFAMiSSF103378 SSF103378, 1 hit
TIGRFAMsiTIGR02330 prpD, 1 hit

Sequencei

Sequence statusi: Complete.

Q12428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLAKNLKNN KIKVCLPKKK FAALSTASIQ TNERPNPDKV LKDIAKYVHE
60 70 80 90 100
TPLKSSLALD TARLCFLDTL GCGLAALKFK QAQNIIKPIV PGTIVPSGTK
110 120 130 140 150
ILGTSYVMDP VKGAFAIGTL IRWLDYNDCW LAAEWGHPSD NLGGILAVAD
160 170 180 190 200
HLSRLNKATH GKNGKQFLVK DVLEAMIKAH EIQGIIALEN SFNKVGLDHV
210 220 230 240 250
VLVKVATAGV VSKMLGLSQE QTIEALSQAF VDGQSLRTYR HAPNTGSRKS
260 270 280 290 300
WAAGDAVSRA VNLAYLVKNA NVGTIPSVLT ARTWGFYDVL FKGKPFSFQQ
310 320 330 340 350
RSKYDSYVME NVLFKISFPA EFHAQTAVEA AVKAYRILAK QGKTFKDIKS
360 370 380 390 400
IRIRTQEAAM RIIDKSGPLY NYADRDHCIQ YMIAVPLITG NLTATDYSDE
410 420 430 440 450
VARNPEIDNL RSKMYCIEDT HLTQNYHDPD KRSIGNALLI ELNDGTQLDE
460 470 480 490 500
IFVEYPVGHK FRREEGIPLL MNKFQRHLRE HFVESPDKVD LIMKVSSKTN
510
FLNMQIDKYM DLFTEG
Length:516
Mass (Da):57,684
Last modified:November 1, 1996 - v1
Checksum:i2ED7F1AF648F2AAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA Translation: CAA95042.1
Z48951 Genomic DNA Translation: CAA88780.1
U31900 Genomic DNA Translation: AAA97581.1
BK006949 Genomic DNA Translation: DAA11429.1
PIRiS52815
RefSeqiNP_015326.1, NM_001184099.1

Genome annotation databases

EnsemblFungiiYPR002W; YPR002W; YPR002W
GeneIDi856108
KEGGisce:YPR002W

Similar proteinsi

Entry informationi

Entry nameiPRPD_YEAST
AccessioniPrimary (citable) accession number: Q12428
Secondary accession number(s): D6W413
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome