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Protein

Iron-sulfur assembly protein 2

Gene

ISA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.1 Publication

Miscellaneous

Present with 1560 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi89IronBy similarity1
Metal bindingi175IronBy similarity1
Metal bindingi177IronBy similarity1

GO - Molecular functioni

GO - Biological processi

  • biotin biosynthetic process Source: SGD
  • iron-sulfur cluster assembly Source: SGD
  • protein maturation Source: GO_Central
  • protein maturation by iron-sulfur cluster transfer Source: SGD

Keywordsi

LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34215-MONOMER
ReactomeiR-SCE-1362409 Mitochondrial iron-sulfur cluster biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur assembly protein 2
Gene namesi
Name:ISA2
Ordered Locus Names:YPR067W
ORF Names:YP9499.22
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR067W
SGDiS000006271 ISA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000770351 – 185Iron-sulfur assembly protein 2Add BLAST185

Proteomic databases

MaxQBiQ12425
PaxDbiQ12425
PRIDEiQ12425

Interactioni

Protein-protein interaction databases

BioGridi36239, 25 interactors
DIPiDIP-6434N
IntActiQ12425, 1 interactor
MINTiQ12425
STRINGi4932.YPR067W

Structurei

3D structure databases

ProteinModelPortaliQ12425
SMRiQ12425
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HesB/IscA family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000005700
HOGENOMiHOG000228313
InParanoidiQ12425
KOiK22072
OMAiYTSTACG
OrthoDBiEOG092C5QRY

Family and domain databases

Gene3Di2.60.300.12, 1 hit
InterProiView protein in InterPro
IPR000361 FeS_biogenesis
IPR017870 FeS_cluster_insertion_CS
IPR035903 HesB-like_dom_sf
PfamiView protein in Pfam
PF01521 Fe-S_biosyn, 1 hit
SUPFAMiSSF89360 SSF89360, 1 hit
PROSITEiView protein in PROSITE
PS01152 HESB, 1 hit

Sequencei

Sequence statusi: Complete.

Q12425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAKLLFTRL NFRRPSTTLR QFPLTCFLFH SKAFYSDLVT KEPLITPKRI
60 70 80 90 100
INKTPGLNLS ISERASNRLA EIYRNSKENL RISVESGGCH GFQYNLTLEP
110 120 130 140 150
ATKPDIKNDV KDKEFSDDLD DDDSKDIIYV LPEDKGRVII DSKSLNILNN
160 170 180
TTLTYTNELI GSSFKIINGS LKSSCGCGSS FDIEN
Length:185
Mass (Da):20,877
Last modified:November 1, 1996 - v1
Checksum:iA4719A9EC54EECF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71255 Genomic DNA Translation: CAA94975.1
Z49219 Genomic DNA Translation: CAA89184.1
BK006949 Genomic DNA Translation: DAA11487.1
PIRiS54088
RefSeqiNP_015392.1, NM_001184164.1

Genome annotation databases

EnsemblFungiiYPR067W; YPR067W; YPR067W
GeneIDi856180
KEGGisce:YPR067W

Similar proteinsi

Entry informationi

Entry nameiISA2_YEAST
AccessioniPrimary (citable) accession number: Q12425
Secondary accession number(s): D6W471
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Rhizobium plasmid pNGR234a
    Rhizobium plasmid pNGR234a: entries and gene names
  2. Protein nomenclature information
    List of publications dealing with protein nomenclature and links to specialized websites

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