Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q12407 (YD199_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative metabolite transport protein YDL199C
Gene names
Ordered Locus Names:YDL199C
ORF Names:D1209
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length687 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

substrate-specific transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

HSP82P028292EBI-33162,EBI-8659

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 687687Putative metabolite transport protein YDL199C
PRO_0000242140

Regions

Topological domain1 – 122122Extracellular Potential
Transmembrane123 – 14321Helical; Potential
Topological domain144 – 16421Cytoplasmic Potential
Transmembrane165 – 18521Helical; Potential
Topological domain186 – 1927Extracellular Potential
Transmembrane193 – 21321Helical; Potential
Topological domain214 – 2163Cytoplasmic Potential
Transmembrane217 – 23721Helical; Potential
Topological domain238 – 25114Extracellular Potential
Transmembrane252 – 27221Helical; Potential
Topological domain273 – 28311Cytoplasmic Potential
Transmembrane284 – 30421Helical; Potential
Topological domain305 – 410106Extracellular Potential
Transmembrane411 – 43121Helical; Potential
Topological domain432 – 4398Cytoplasmic Potential
Transmembrane440 – 46021Helical; Potential
Topological domain461 – 4699Extracellular Potential
Transmembrane470 – 49021Helical; Potential
Topological domain491 – 50010Cytoplasmic Potential
Transmembrane501 – 52121Helical; Potential
Topological domain522 – 53312Extracellular Potential
Transmembrane534 – 55421Helical; Potential
Topological domain555 – 687133Cytoplasmic Potential

Amino acid modifications

Modified residue5341Phosphotyrosine Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q12407 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 06B676FEDC2D570A

FASTA68777,501
        10         20         30         40         50         60 
MKPPLNMSRS NKPLTQEANS SAHIDRAHQL AQDFNSKQDD TALTSLPHKN PDIFRFENNI 

        70         80         90        100        110        120 
TAHSSRRGSL YRDSDATVVL PLSEHTPRLS MDDPYRQLLQ QAEISQLRSK KKRHSSRVLR 

       130        140        150        160        170        180 
TSFISFVVLV SSLSGLDQGL ISGNVMTLSF QKYFHYPLTS PLGNIVSIVN LGAFMASLFV 

       190        200        210        220        230        240 
YSGILEPCSR KKMLQISTMI YSLGAIVQVL ALNQWCLLLG RFLLGVGMGF AFSMVIIYQF 

       250        260        270        280        290        300 
EFPLPCIRKR TLISIQCVSS VIAYSFGIWI NCAFRYLGFA WRYPLSTHVA LGIILNLMSF 

       310        320        330        340        350        360 
YLILESPSWL LKQKNDVEAL VLISNVFDDG NFEENQTQLK FRVLKRDILL KSHLQKNSYP 

       370        380        390        400        410        420 
YAYILKDFSS IIKLLIGFQL LTRTNGVDAF LYYSPLILQQ MGRGERKSIY LTGLNALIYS 

       430        440        450        460        470        480 
IVILAYVPLV LRKRKEKTNV LLGSIVMCAL LFTISFTDWF PKSTTRYISI LFAVFLFTHF 

       490        500        510        520        530        540 
ISWDSIGWVM TIELLPHLSQ APVILLVSNF YWIFKWFVSL ITPILIDRLS WKFYLIPSLS 

       550        560        570        580        590        600 
SFISIIFVLK IFPIETRDER LDSDDDSTGN GSGNHDDVFD DTGSEFSSSP SFSAYQINTL 

       610        620        630        640        650        660 
GSSIKQNNQA YSSIQNEQIL PKNGNLSNQT HGSAQNVYFI TSDSGPSRTG EFFSFHNRTD 

       670        680 
PNISDNIAAN KPSSGGGQNS PGDMAVA

« Hide

References

« Hide 'large scale' references
[1]"New open reading frames, one of which is similar to the nifV gene of Azotobacter vinelandii, found on a 12.5 kbp fragment of chromosome IV of Saccharomyces cerevisiae."
Verhasselt P., Voet M., Volckaert G.
Yeast 11:961-966(1995) [PubMed: 8533471] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[2]"The nucleotide sequence of a 39 kb segment of yeast chromosome IV: 12 new open reading frames, nine known genes and one gene for Gly-tRNA."
Bahr A., Moeller-Rieker S., Hankeln T., Kraemer C., Protin U., Schmidt E.R.
Yeast 13:163-169(1997) [PubMed: 9046097] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed: 9169867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[6]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-534, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X83276 Genomic DNA. Translation: CAA58248.1.
X99000 Genomic DNA. Translation: CAA67470.1.
Z74247 Genomic DNA. Translation: CAA98776.1.
BK006938 Genomic DNA. Translation: DAA11665.1.
PIRS58778.
RefSeqNP_010082.1. NM_001180259.1.

3D structure databases

ProteinModelPortalQ12407.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-8956N.
IntActQ12407. 2 interactions.
MINTMINT-2491777.
STRINGQ12407.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDL199C; YDL199C; YDL199C.
GeneID851328.
KEGGsce:YDL199C.
NMPDRfig|4932.3.peg.815.

Organism-specific databases

CYGDYDL199c.
SGDS000002358. YDL199C.

Phylogenomic databases

eggNOGfuNOG06872.
GeneTreeEFGT00070000008780.
OMADVEDDHA.
OrthoDBEOG4DJP4W.

Gene expression databases

ArrayExpressQ12407.
GenevestigatorQ12407.
GermOnlineYDL199C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968384.

Entry information

Entry nameYD199_YEAST
AccessionPrimary (citable) accession number: Q12407
Secondary accession number(s): D6VRF5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: December 14, 2011
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents