Reviewed,
UniProtKB/Swiss-Prot Q12402 (YOP1_YEAST)
Last modified
June 16, 2009.
Version 59.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Protein YOP1 Alternative name(s): YIP1 partner protein 1 YPT-interacting protein 2 | ||||||||
| Gene names |
| ||||||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||||||
| Taxonomic identifier | 4932 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 180 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in membrane/vesicle trafficking. Ref.5 |
| Subunit structure | Interacts with YIP1. Ref.4 |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Ref.4 Ref.6 |
| Miscellaneous | Present with 1759 molecules/cell in log phase SD medium. Ref.7 |
| Sequence similarities | Belongs to the DP1 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Golgi apparatus Membrane |
| Domain | Transmembrane |
| PTM | Acetylation |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | protein import into nucleus Inferred from genetic interaction. Source: SGD vesicle-mediated transport Ref.4 Ref.5Inferred from mutant phenotype. Source: SGD |
| Cellular component | Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membraneInferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Ref.4Inferred from direct assay. Source: SGD |
| Molecular function | identical protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.3 | ||||||
| Chain | 2 – 180 | 179 | Protein YOP1 | PRO_0000101859 | |||||
Regions | |||||||||
| Transmembrane | 39 – 59 | 21 | Potential | ||||||
| Transmembrane | 61 – 81 | 21 | Potential | ||||||
| Transmembrane | 89 – 109 | 21 | Potential | ||||||
| Transmembrane | 110 – 130 | 21 | Potential | ||||||
| Region | 2 – 17 | 16 | Interaction with YIP1 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylserine Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Matern H.T., Gallwitz D. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.  Hani J.Nature 387:103-105(1997) [PubMed: 9169875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972. |
| [3] | Bienvenut W.V., Peters C. Submitted (MAY-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-13; 24-31 AND 143-150, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY. |
| [4] | "Yop1p, the yeast homolog of the polyposis locus protein 1, interacts with Yip1p and negatively regulates cell growth." Calero M., Whittaker G.R., Collins R.N. J. Biol. Chem. 276:12100-12112(2001) [PubMed: 11278413] [Abstract] Cited for: INTERACTION WITH YIP1, SUBCELLULAR LOCATION. |
| [5] | "Function of a plant stress-induced gene, HVA22. Synthetic enhancement screen with its yeast homolog reveals its role in vesicular traffic." Brands A., Ho T.-H.D. Plant Physiol. 130:1121-1131(2002) [PubMed: 12427979] [Abstract] Cited for: FUNCTION. |
| [6] | "Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
| [7] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AJ007902 Genomic DNA. Translation: CAA07720.1. Z71255 Genomic DNA. Translation: CAA95024.1. Z49274 Genomic DNA. Translation: CAA89282.1. | |
| PIR | S54502. |
| RefSeq | NP_015353.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:3914N. |
| IntAct | Q12402. 74 interactions. |
Genome annotation databases | |
| Ensembl | YPR028W. Saccharomyces cerevisiae. [Contig view] |
| GeneID | 856140. |
| GenomeReviews | Gene locus YPR028W in contig U00094_GR. |
| KEGG | sce:YPR028W. |
| NMPDR | fig|4932.3.peg.6488. |
Organism-specific databases | |
| CYGD | YPR028w. |
| SGD | S000006232. YOP1. |
| Yeast-GFP | Search... |
Phylogenomic databases | |
| HOGENOM | Q12402. |
| OMA | Q12402. CAFLVWC. |
Gene expression databases | |
| ArrayExpress | Q12402. |
| GermOnline | YPR028W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR004345. TB2_DP1_HVA22. [Graphical view] |
| PANTHER | PTHR12300. TB2_DP1_HVA22. 1 hit. |
| Pfam | PF03134. TB2_DP1_HVA22. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 981250. |
Entry information
| Entry name | YOP1_YEAST | ||||||||
| Accession | Primary (citable) accession number: Q12402 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |
