Q12402 (YOP1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein YOP1

Alternative name(s):
YIP1 partner protein 1
YPT-interacting protein 2

Gene names

Name:	YOP1
Synonyms:	YIP2
Ordered Locus Names:	YPR028W
ORF Names:	YP9367.08

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in membrane/vesicle trafficking. Ref.6
Subunit structure	Interacts with YIP1. Ref.5
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein Ref.5 Ref.7.
Miscellaneous	Present with 1759 molecules/cell in log phase SD medium. Ref.8
Sequence similarities	Belongs to the DP1 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Golgi apparatus Membrane
Domain	Transmembrane Transmembrane helix
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	endoplasmic reticulum inheritance Inferred from genetic interaction. Source: UniProtKB endoplasmic reticulum tubular network organization Inferred from mutant phenotype. Source: UniProtKB nuclear pore complex assembly Inferred from genetic interaction. Source: SGD vesicle-mediated transport Inferred from mutant phenotype Ref.5Ref.6. Source: SGD
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from direct assay Ref.5. Source: SGD
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PEX30	Q06169	3	EBI-37092,EBI-31008
SEY1	Q99287	4	EBI-37092,EBI-37523

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.4
	Chain	2 – 180	179	Protein YOP1		PRO_0000101859
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	61 – 81	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential
	Transmembrane	110 – 130	21	Helical; Potential
	Region	2 – 17	16	Interaction with YIP1
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q12402 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 6F1073444B653CCF	FASTA	180	20,270
	10 20 30 40 50 60 MSEYASSIHS QMKQFDTKYS GNRILQQLEN KTNLPKSYLV AGLGFAYLLL IFINVGGVGE 70 80 90 100 110 120 ILSNFAGFVL PAYLSLVALK TPTSTDDTQL LTYWIVFSFL SVIEFWSKAI LYLIPFYWFL 130 140 150 160 170 180 KTVFLIYIAL PQTGGARMIY QKIVAPLTDR YILRDVSKTE KDEIRASVNE ASKATGASVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Matern H.T., Gallwitz D. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI." Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J. Nature 387:103-105(1997) [PubMed: 9169875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	Bienvenut W.V., Peters C. Submitted (MAY-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-13; 24-31 AND 143-150, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY.
[5]	"Yop1p, the yeast homolog of the polyposis locus protein 1, interacts with Yip1p and negatively regulates cell growth." Calero M., Whittaker G.R., Collins R.N. J. Biol. Chem. 276:12100-12112(2001) [PubMed: 11278413] [Abstract] Cited for: INTERACTION WITH YIP1, SUBCELLULAR LOCATION.
[6]	"Function of a plant stress-induced gene, HVA22. Synthetic enhancement screen with its yeast homolog reveals its role in vesicular traffic." Brands A., Ho T.-H.D. Plant Physiol. 130:1121-1131(2002) [PubMed: 12427979] [Abstract] Cited for: FUNCTION.
[7]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ007902 Genomic DNA. Translation: CAA07720.1. Z71255 Genomic DNA. Translation: CAA95024.1. Z49274 Genomic DNA. Translation: CAA89282.1. BK006949 Genomic DNA. Translation: DAA11454.1.
PIR	S54502.
RefSeq	NP_015353.1. NM_001184125.1.
3D structure databases
ProteinModelPortal	Q12402.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3914N.
IntAct	Q12402. 57 interactions.
MINT	MINT-480869.
STRING	Q12402.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YPR028W; YPR028W; YPR028W.
GeneID	856140.
KEGG	sce:YPR028W.
NMPDR	fig|4932.3.peg.6488.
Organism-specific databases
SGD	S000006232. YOP1.
Phylogenomic databases
eggNOG	fuNOG09230.
GeneTree	EFGT00050000004652.
HOGENOM	HBG630822.
OMA	LSVIEFW.
OrthoDB	EOG480N6B.
Gene expression databases
ArrayExpress	Q12402.
Genevestigator	Q12402.
GermOnline	YPR028W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR004345. TB2_DP1_HVA22. [Graphical view]
PANTHER	PTHR12300. TB2_DP1_HVA22. 1 hit.
Pfam	PF03134. TB2_DP1_HVA22. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	981250.

Entry information

Entry name

YOP1_YEAST

Accession

Primary (citable) accession number: Q12402
Secondary accession number(s): D6W438

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	January 23, 2007
Last modified:	December 14, 2011
This is version 82 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program