Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q12402 (YOP1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein YOP1
Alternative name(s):
YIP1 partner protein 1
YPT-interacting protein 2
Gene names
Name:YOP1
Synonyms:YIP2
Ordered Locus Names:YPR028W
ORF Names:YP9367.08
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in membrane/vesicle trafficking. Ref.6

Subunit structure

Interacts with YIP1. Ref.5

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein Ref.5 Ref.7.

Miscellaneous

Present with 1759 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the DP1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SEY1Q992872EBI-37092,EBI-37523

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 180179Protein YOP1
PRO_0000101859

Regions

Transmembrane39 – 5921Helical; Potential
Transmembrane61 – 8121Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane110 – 13021Helical; Potential
Region2 – 1716Interaction with YIP1

Amino acid modifications

Modified residue21N-acetylserine Ref.4 Ref.9

Sequences

Sequence LengthMass (Da)Tools
Q12402 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 6F1073444B653CCF

FASTA18020,270
        10         20         30         40         50         60 
MSEYASSIHS QMKQFDTKYS GNRILQQLEN KTNLPKSYLV AGLGFAYLLL IFINVGGVGE 

        70         80         90        100        110        120 
ILSNFAGFVL PAYLSLVALK TPTSTDDTQL LTYWIVFSFL SVIEFWSKAI LYLIPFYWFL 

       130        140        150        160        170        180 
KTVFLIYIAL PQTGGARMIY QKIVAPLTDR YILRDVSKTE KDEIRASVNE ASKATGASVH 

« Hide

References

« Hide 'large scale' references
[1]Matern H.T., Gallwitz D.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]Bienvenut W.V., Peters C.
Submitted (MAY-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-13; 24-31 AND 143-150, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
[5]"Yop1p, the yeast homolog of the polyposis locus protein 1, interacts with Yip1p and negatively regulates cell growth."
Calero M., Whittaker G.R., Collins R.N.
J. Biol. Chem. 276:12100-12112(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH YIP1, SUBCELLULAR LOCATION.
[6]"Function of a plant stress-induced gene, HVA22. Synthetic enhancement screen with its yeast homolog reveals its role in vesicular traffic."
Brands A., Ho T.-H.D.
Plant Physiol. 130:1121-1131(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ007902 Genomic DNA. Translation: CAA07720.1.
Z71255 Genomic DNA. Translation: CAA95024.1.
Z49274 Genomic DNA. Translation: CAA89282.1.
BK006949 Genomic DNA. Translation: DAA11454.1.
PIRS54502.
RefSeqNP_015353.1. NM_001184125.1.

3D structure databases

ProteinModelPortalQ12402.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36206. 76 interactions.
DIPDIP-3914N.
IntActQ12402. 8 interactions.
MINTMINT-480869.
STRING4932.YPR028W.

Proteomic databases

PaxDbQ12402.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPR028W; YPR028W; YPR028W.
GeneID856140.
KEGGsce:YPR028W.

Organism-specific databases

SGDS000006232. YOP1.

Phylogenomic databases

eggNOGCOG5052.
GeneTreeENSGT00550000074535.
HOGENOMHOG000172351.
KOK17279.
OMAVPKSYAF.
OrthoDBEOG7WX0NB.

Enzyme and pathway databases

BioCycYEAST:G3O-34187-MONOMER.

Gene expression databases

GenevestigatorQ12402.

Family and domain databases

InterProIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERPTHR12300. PTHR12300. 1 hit.
PfamPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio981250.
PROQ12402.

Entry information

Entry nameYOP1_YEAST
AccessionPrimary (citable) accession number: Q12402
Secondary accession number(s): D6W438
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families