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Q12402

- YOP1_YEAST

UniProt

Q12402 - YOP1_YEAST

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Protein
Protein YOP1
Gene
YOP1, YIP2, YPR028W, YP9367.08
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in membrane/vesicle trafficking.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. endoplasmic reticulum inheritance Source: UniProtKB
  2. endoplasmic reticulum organization Source: SGD
  3. endoplasmic reticulum tubular network organization Source: UniProtKB
  4. nuclear pore complex assembly Source: SGD
  5. vesicle-mediated transport Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-34187-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YOP1
Alternative name(s):
YIP1 partner protein 1
YPT-interacting protein 2
Gene namesi
Name:YOP1
Synonyms:YIP2
Ordered Locus Names:YPR028W
ORF Names:YP9367.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

SGDiS000006232. YOP1.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921Helical; Reviewed prediction
Add
BLAST
Transmembranei61 – 8121Helical; Reviewed prediction
Add
BLAST
Transmembranei89 – 10921Helical; Reviewed prediction
Add
BLAST
Transmembranei110 – 13021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. endoplasmic reticulum Source: SGD
  3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  4. endoplasmic reticulum tubular network Source: SGD
  5. integral component of membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 180179Protein YOP1
PRO_0000101859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ12402.
PaxDbiQ12402.

Expressioni

Gene expression databases

GenevestigatoriQ12402.

Interactioni

Subunit structurei

Interacts with YIP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SEY1Q992872EBI-37092,EBI-37523

Protein-protein interaction databases

BioGridi36206. 76 interactions.
DIPiDIP-3914N.
IntActiQ12402. 8 interactions.
MINTiMINT-480869.
STRINGi4932.YPR028W.

Structurei

3D structure databases

ProteinModelPortaliQ12402.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 1716Interaction with YIP1
Add
BLAST

Sequence similaritiesi

Belongs to the DP1 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5052.
GeneTreeiENSGT00550000074535.
HOGENOMiHOG000172351.
KOiK17279.
OMAiKFIFLLW.
OrthoDBiEOG7WX0NB.

Family and domain databases

InterProiIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERiPTHR12300. PTHR12300. 1 hit.
PfamiPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12402-1 [UniParc]FASTAAdd to Basket

« Hide

MSEYASSIHS QMKQFDTKYS GNRILQQLEN KTNLPKSYLV AGLGFAYLLL    50
IFINVGGVGE ILSNFAGFVL PAYLSLVALK TPTSTDDTQL LTYWIVFSFL 100
SVIEFWSKAI LYLIPFYWFL KTVFLIYIAL PQTGGARMIY QKIVAPLTDR 150
YILRDVSKTE KDEIRASVNE ASKATGASVH 180
Length:180
Mass (Da):20,270
Last modified:January 23, 2007 - v3
Checksum:i6F1073444B653CCF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007902 Genomic DNA. Translation: CAA07720.1.
Z71255 Genomic DNA. Translation: CAA95024.1.
Z49274 Genomic DNA. Translation: CAA89282.1.
BK006949 Genomic DNA. Translation: DAA11454.1.
PIRiS54502.
RefSeqiNP_015353.1. NM_001184125.1.

Genome annotation databases

EnsemblFungiiYPR028W; YPR028W; YPR028W.
GeneIDi856140.
KEGGisce:YPR028W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ007902 Genomic DNA. Translation: CAA07720.1 .
Z71255 Genomic DNA. Translation: CAA95024.1 .
Z49274 Genomic DNA. Translation: CAA89282.1 .
BK006949 Genomic DNA. Translation: DAA11454.1 .
PIRi S54502.
RefSeqi NP_015353.1. NM_001184125.1.

3D structure databases

ProteinModelPortali Q12402.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36206. 76 interactions.
DIPi DIP-3914N.
IntActi Q12402. 8 interactions.
MINTi MINT-480869.
STRINGi 4932.YPR028W.

Proteomic databases

MaxQBi Q12402.
PaxDbi Q12402.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR028W ; YPR028W ; YPR028W .
GeneIDi 856140.
KEGGi sce:YPR028W.

Organism-specific databases

SGDi S000006232. YOP1.

Phylogenomic databases

eggNOGi COG5052.
GeneTreei ENSGT00550000074535.
HOGENOMi HOG000172351.
KOi K17279.
OMAi KFIFLLW.
OrthoDBi EOG7WX0NB.

Enzyme and pathway databases

BioCyci YEAST:G3O-34187-MONOMER.

Miscellaneous databases

NextBioi 981250.
PROi Q12402.

Gene expression databases

Genevestigatori Q12402.

Family and domain databases

InterProi IPR004345. TB2_DP1_HVA22.
[Graphical view ]
PANTHERi PTHR12300. PTHR12300. 1 hit.
Pfami PF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Matern H.T., Gallwitz D.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Bienvenut W.V., Peters C.
    Submitted (MAY-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-13; 24-31 AND 143-150, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Yop1p, the yeast homolog of the polyposis locus protein 1, interacts with Yip1p and negatively regulates cell growth."
    Calero M., Whittaker G.R., Collins R.N.
    J. Biol. Chem. 276:12100-12112(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH YIP1, SUBCELLULAR LOCATION.
  6. "Function of a plant stress-induced gene, HVA22. Synthetic enhancement screen with its yeast homolog reveals its role in vesicular traffic."
    Brands A., Ho T.-H.D.
    Plant Physiol. 130:1121-1131(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYOP1_YEAST
AccessioniPrimary (citable) accession number: Q12402
Secondary accession number(s): D6W438
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1759 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

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