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Q12402

- YOP1_YEAST

UniProt

Q12402 - YOP1_YEAST

Protein

Protein YOP1

Gene

YOP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in membrane/vesicle trafficking.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. endoplasmic reticulum inheritance Source: UniProtKB
    2. endoplasmic reticulum organization Source: SGD
    3. endoplasmic reticulum tubular network organization Source: UniProtKB
    4. nuclear pore complex assembly Source: SGD
    5. vesicle-mediated transport Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-34187-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein YOP1
    Alternative name(s):
    YIP1 partner protein 1
    YPT-interacting protein 2
    Gene namesi
    Name:YOP1
    Synonyms:YIP2
    Ordered Locus Names:YPR028W
    ORF Names:YP9367.08
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    SGDiS000006232. YOP1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. endoplasmic reticulum tubular network Source: SGD
    4. Golgi membrane Source: UniProtKB-SubCell
    5. integral component of membrane Source: SGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 180179Protein YOP1PRO_0000101859Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ12402.
    PaxDbiQ12402.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12402.

    Interactioni

    Subunit structurei

    Interacts with YIP1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SEY1Q992872EBI-37092,EBI-37523

    Protein-protein interaction databases

    BioGridi36206. 76 interactions.
    DIPiDIP-3914N.
    IntActiQ12402. 8 interactions.
    MINTiMINT-480869.
    STRINGi4932.YPR028W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12402.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 1716Interaction with YIP1Add
    BLAST

    Sequence similaritiesi

    Belongs to the DP1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5052.
    GeneTreeiENSGT00550000074535.
    HOGENOMiHOG000172351.
    KOiK17279.
    OMAiKFIFLLW.
    OrthoDBiEOG7WX0NB.

    Family and domain databases

    InterProiIPR004345. TB2_DP1_HVA22.
    [Graphical view]
    PANTHERiPTHR12300. PTHR12300. 1 hit.
    PfamiPF03134. TB2_DP1_HVA22. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q12402-1 [UniParc]FASTAAdd to Basket

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    MSEYASSIHS QMKQFDTKYS GNRILQQLEN KTNLPKSYLV AGLGFAYLLL    50
    IFINVGGVGE ILSNFAGFVL PAYLSLVALK TPTSTDDTQL LTYWIVFSFL 100
    SVIEFWSKAI LYLIPFYWFL KTVFLIYIAL PQTGGARMIY QKIVAPLTDR 150
    YILRDVSKTE KDEIRASVNE ASKATGASVH 180
    Length:180
    Mass (Da):20,270
    Last modified:January 23, 2007 - v3
    Checksum:i6F1073444B653CCF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007902 Genomic DNA. Translation: CAA07720.1.
    Z71255 Genomic DNA. Translation: CAA95024.1.
    Z49274 Genomic DNA. Translation: CAA89282.1.
    BK006949 Genomic DNA. Translation: DAA11454.1.
    PIRiS54502.
    RefSeqiNP_015353.1. NM_001184125.1.

    Genome annotation databases

    EnsemblFungiiYPR028W; YPR028W; YPR028W.
    GeneIDi856140.
    KEGGisce:YPR028W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007902 Genomic DNA. Translation: CAA07720.1 .
    Z71255 Genomic DNA. Translation: CAA95024.1 .
    Z49274 Genomic DNA. Translation: CAA89282.1 .
    BK006949 Genomic DNA. Translation: DAA11454.1 .
    PIRi S54502.
    RefSeqi NP_015353.1. NM_001184125.1.

    3D structure databases

    ProteinModelPortali Q12402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36206. 76 interactions.
    DIPi DIP-3914N.
    IntActi Q12402. 8 interactions.
    MINTi MINT-480869.
    STRINGi 4932.YPR028W.

    Proteomic databases

    MaxQBi Q12402.
    PaxDbi Q12402.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPR028W ; YPR028W ; YPR028W .
    GeneIDi 856140.
    KEGGi sce:YPR028W.

    Organism-specific databases

    SGDi S000006232. YOP1.

    Phylogenomic databases

    eggNOGi COG5052.
    GeneTreei ENSGT00550000074535.
    HOGENOMi HOG000172351.
    KOi K17279.
    OMAi KFIFLLW.
    OrthoDBi EOG7WX0NB.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-34187-MONOMER.

    Miscellaneous databases

    NextBioi 981250.
    PROi Q12402.

    Gene expression databases

    Genevestigatori Q12402.

    Family and domain databases

    InterProi IPR004345. TB2_DP1_HVA22.
    [Graphical view ]
    PANTHERi PTHR12300. PTHR12300. 1 hit.
    Pfami PF03134. TB2_DP1_HVA22. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Matern H.T., Gallwitz D.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Bienvenut W.V., Peters C.
      Submitted (MAY-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-13; 24-31 AND 143-150, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    5. "Yop1p, the yeast homolog of the polyposis locus protein 1, interacts with Yip1p and negatively regulates cell growth."
      Calero M., Whittaker G.R., Collins R.N.
      J. Biol. Chem. 276:12100-12112(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH YIP1, SUBCELLULAR LOCATION.
    6. "Function of a plant stress-induced gene, HVA22. Synthetic enhancement screen with its yeast homolog reveals its role in vesicular traffic."
      Brands A., Ho T.-H.D.
      Plant Physiol. 130:1121-1131(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiYOP1_YEAST
    AccessioniPrimary (citable) accession number: Q12402
    Secondary accession number(s): D6W438
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1759 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3