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Protein

Protein YOP1

Gene

YOP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in membrane/vesicle trafficking.1 Publication

GO - Biological processi

  • endoplasmic reticulum inheritance Source: UniProtKB
  • endoplasmic reticulum organization Source: SGD
  • endoplasmic reticulum tubular network organization Source: UniProtKB
  • nuclear pore complex assembly Source: SGD
  • vesicle-mediated transport Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-34187-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YOP1
Alternative name(s):
YIP1 partner protein 1
YPT-interacting protein 2
Gene namesi
Name:YOP1
Synonyms:YIP2
Ordered Locus Names:YPR028W
ORF Names:YP9367.08
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR028W.
SGDiS000006232. YOP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: SGD
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • endoplasmic reticulum tubular network Source: SGD
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 180179Protein YOP1PRO_0000101859Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ12402.
PaxDbiQ12402.

Interactioni

Subunit structurei

Interacts with YIP1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SEY1Q992872EBI-37092,EBI-37523

Protein-protein interaction databases

BioGridi36206. 86 interactions.
DIPiDIP-3914N.
IntActiQ12402. 8 interactions.
MINTiMINT-480869.

Structurei

3D structure databases

ProteinModelPortaliQ12402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 1716Interaction with YIP1Add
BLAST

Sequence similaritiesi

Belongs to the DP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5052.
GeneTreeiENSGT00550000074535.
HOGENOMiHOG000172351.
InParanoidiQ12402.
KOiK17279.
OMAiFIIPGYY.
OrthoDBiEOG7WX0NB.

Family and domain databases

InterProiIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERiPTHR12300. PTHR12300. 1 hit.
PfamiPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12402-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEYASSIHS QMKQFDTKYS GNRILQQLEN KTNLPKSYLV AGLGFAYLLL
60 70 80 90 100
IFINVGGVGE ILSNFAGFVL PAYLSLVALK TPTSTDDTQL LTYWIVFSFL
110 120 130 140 150
SVIEFWSKAI LYLIPFYWFL KTVFLIYIAL PQTGGARMIY QKIVAPLTDR
160 170 180
YILRDVSKTE KDEIRASVNE ASKATGASVH
Length:180
Mass (Da):20,270
Last modified:January 23, 2007 - v3
Checksum:i6F1073444B653CCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007902 Genomic DNA. Translation: CAA07720.1.
Z71255 Genomic DNA. Translation: CAA95024.1.
Z49274 Genomic DNA. Translation: CAA89282.1.
BK006949 Genomic DNA. Translation: DAA11454.1.
PIRiS54502.
RefSeqiNP_015353.1. NM_001184125.1.

Genome annotation databases

EnsemblFungiiYPR028W; YPR028W; YPR028W.
GeneIDi856140.
KEGGisce:YPR028W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007902 Genomic DNA. Translation: CAA07720.1.
Z71255 Genomic DNA. Translation: CAA95024.1.
Z49274 Genomic DNA. Translation: CAA89282.1.
BK006949 Genomic DNA. Translation: DAA11454.1.
PIRiS54502.
RefSeqiNP_015353.1. NM_001184125.1.

3D structure databases

ProteinModelPortaliQ12402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36206. 86 interactions.
DIPiDIP-3914N.
IntActiQ12402. 8 interactions.
MINTiMINT-480869.

Proteomic databases

MaxQBiQ12402.
PaxDbiQ12402.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR028W; YPR028W; YPR028W.
GeneIDi856140.
KEGGisce:YPR028W.

Organism-specific databases

EuPathDBiFungiDB:YPR028W.
SGDiS000006232. YOP1.

Phylogenomic databases

eggNOGiCOG5052.
GeneTreeiENSGT00550000074535.
HOGENOMiHOG000172351.
InParanoidiQ12402.
KOiK17279.
OMAiFIIPGYY.
OrthoDBiEOG7WX0NB.

Enzyme and pathway databases

BioCyciYEAST:G3O-34187-MONOMER.

Miscellaneous databases

NextBioi981250.
PROiQ12402.

Family and domain databases

InterProiIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERiPTHR12300. PTHR12300. 1 hit.
PfamiPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Matern H.T., Gallwitz D.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Bienvenut W.V., Peters C.
    Submitted (MAY-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-13; 24-31 AND 143-150, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
  5. "Yop1p, the yeast homolog of the polyposis locus protein 1, interacts with Yip1p and negatively regulates cell growth."
    Calero M., Whittaker G.R., Collins R.N.
    J. Biol. Chem. 276:12100-12112(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH YIP1, SUBCELLULAR LOCATION.
  6. "Function of a plant stress-induced gene, HVA22. Synthetic enhancement screen with its yeast homolog reveals its role in vesicular traffic."
    Brands A., Ho T.-H.D.
    Plant Physiol. 130:1121-1131(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYOP1_YEAST
AccessioniPrimary (citable) accession number: Q12402
Secondary accession number(s): D6W438
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1759 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.