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Reviewed, UniProtKB/Swiss-Prot Q12402 (YOP1_YEAST)

Last modified June 16, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein YOP1
Alternative name(s):
    YIP1 partner protein 1
    YPT-interacting protein 2
Gene names
Name: YOP1
Synonyms: YIP2
Ordered Locus Names: YPR028W
ORF Names: YP9367.08
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in membrane/vesicle trafficking. Ref.5

Subunit structure

Interacts with YIP1. Ref.4

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Ref.4 Ref.6

Miscellaneous

Present with 1759 molecules/cell in log phase SD medium. Ref.7

Sequence similarities

Belongs to the DP1 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself1EBI-37092,EBI-37092
P360761EBI-37092,EBI-26778
P388451EBI-37092,EBI-24770
P532781EBI-37092,EBI-23314
Q120661EBI-37092,EBI-35877
Q121441EBI-37092,EBI-37691
Q121641EBI-37092,EBI-30000
AGP1P253761EBI-37092,EBI-2357
ARO8P530901EBI-37092,EBI-2042933
CBR1P386261EBI-37092,EBI-2048224
CHO1P084561EBI-37092,EBI-14055
CYS4P325821EBI-37092,EBI-4167
DNM1P548611EBI-37092,EBI-6002
ERG11P106141EBI-37092,EBI-5127
ERP1Q053591EBI-37092,EBI-6581
ERV25P548371EBI-37092,EBI-6642
GAP1P191451EBI-37092,EBI-7314
GLN1P322881EBI-37092,EBI-7665
GOT1Q035541EBI-37092,EBI-2057821
GRX2P176951EBI-37092,EBI-7699
GTT1P405821EBI-37092,EBI-7941
HSP12P229431EBI-37092,EBI-8548
IPP1P008171EBI-37092,EBI-9338
LSP1Q122301EBI-37092,EBI-34978
NUP120P357291EBI-37092,EBI-11713
NUP145P496871EBI-37092,EBI-11730
OSH7P387551EBI-37092,EBI-12641
OST1P415431EBI-37092,EBI-12651
PEX30Q061692EBI-37092,EBI-31008
PEX31P532031EBI-37092,EBI-23069
PHO84P252971EBI-37092,EBI-13320
PHO88P382641EBI-37092,EBI-13350
PHS1P408571EBI-37092,EBI-26003
PIS1P061971EBI-37092,EBI-13458
PLM2Q043831EBI-37092,EBI-2079237
PMP2P409751EBI-37092,EBI-2043041
PMP3P872841EBI-37092,EBI-13555
PMR1P135861EBI-37092,EBI-3091
PPZ1P265701EBI-37092,EBI-13807
RBD2Q122701EBI-37092,EBI-31471
RTN1Q049471EBI-37092,EBI-38020
RTN2Q124431EBI-37092,EBI-32591
SAC1P323681EBI-37092,EBI-16210
SCS7Q035291EBI-37092,EBI-16747
SEC27P418111EBI-37092,EBI-4898
SEY1Q992871EBI-37092,EBI-37523
SIS2P360241EBI-37092,EBI-17250
SPF1P399861EBI-37092,EBI-3128
TCB3Q036401EBI-37092,EBI-27872
UBP1P250371EBI-37092,EBI-19819
VAS1P07806-11EBI-37092,EBI-1009942
VHS3Q084381EBI-37092,EBI-30482
VRG4P401071EBI-37092,EBI-7764
YER053C-AQ3E7B01EBI-37092,EBI-2047907
YET1P357231EBI-37092,EBI-26730

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 180179Protein YOP1
PRO_0000101859

Regions

Transmembrane39 – 5921 Potential
Transmembrane61 – 8121 Potential
Transmembrane89 – 10921 Potential
Transmembrane110 – 13021 Potential
Region2 – 1716Interaction with YIP1

Amino acid modifications

Modified residue21N-acetylserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q12402-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 6F1073444B653CCF

FASTA18020,270
        10         20         30         40         50         60 
MSEYASSIHS QMKQFDTKYS GNRILQQLEN KTNLPKSYLV AGLGFAYLLL IFINVGGVGE 

        70         80         90        100        110        120 
ILSNFAGFVL PAYLSLVALK TPTSTDDTQL LTYWIVFSFL SVIEFWSKAI LYLIPFYWFL 

       130        140        150        160        170        180 
KTVFLIYIAL PQTGGARMIY QKIVAPLTDR YILRDVSKTE KDEIRASVNE ASKATGASVH 

« Hide

References

« Hide 'large scale' references
[1]Matern H.T., Gallwitz D.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed: 9169875] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]Bienvenut W.V., Peters C.
Submitted (MAY-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-13; 24-31 AND 143-150, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY.
[4]"Yop1p, the yeast homolog of the polyposis locus protein 1, interacts with Yip1p and negatively regulates cell growth."
Calero M., Whittaker G.R., Collins R.N.
J. Biol. Chem. 276:12100-12112(2001) [PubMed: 11278413] [Abstract]
Cited for: INTERACTION WITH YIP1, SUBCELLULAR LOCATION.
[5]"Function of a plant stress-induced gene, HVA22. Synthetic enhancement screen with its yeast homolog reveals its role in vesicular traffic."
Brands A., Ho T.-H.D.
Plant Physiol. 130:1121-1131(2002) [PubMed: 12427979] [Abstract]
Cited for: FUNCTION.
[6]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

AJ007902 Genomic DNA. Translation: CAA07720.1.
Z71255 Genomic DNA. Translation: CAA95024.1.
Z49274 Genomic DNA. Translation: CAA89282.1.
PIRS54502.
RefSeqNP_015353.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:3914N.
IntActQ12402. 74 interactions.

Genome annotation databases

EnsemblYPR028W. Saccharomyces cerevisiae. [Contig view]
GeneID856140.
GenomeReviewsGene locus YPR028W in contig U00094_GR.
KEGGsce:YPR028W.
NMPDRfig|4932.3.peg.6488.

Organism-specific databases

CYGDYPR028w.
SGDS000006232. YOP1.
Yeast-GFPSearch...

Phylogenomic databases

HOGENOMQ12402.
OMAQ12402. CAFLVWC.

Gene expression databases

ArrayExpressQ12402.
GermOnlineYPR028W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERPTHR12300. TB2_DP1_HVA22. 1 hit.
PfamPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio981250.

Entry information

Entry nameYOP1_YEAST
AccessionPrimary (citable) accession number: Q12402
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 59 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents