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Protein

Protein-L-isoaspartate O-methyltransferase 2

Gene

pcm2

Organism
Polaromonas sp. (strain JS666 / ATCC BAA-500)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei61UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferase 2UniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferase 2UniRule annotation
Protein L-isoaspartyl methyltransferase 2UniRule annotation
Protein-beta-aspartate methyltransferase 2UniRule annotation
Short name:
PIMT 2UniRule annotation
Gene namesi
Name:pcm2UniRule annotation
Ordered Locus Names:Bpro_4278
OrganismiPolaromonas sp. (strain JS666 / ATCC BAA-500)
Taxonomic identifieri296591 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaePolaromonas
Proteomesi
  • UP000001983 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003519021 – 211Protein-L-isoaspartate O-methyltransferase 2Add BLAST211

Interactioni

Protein-protein interaction databases

STRINGi296591.Bpro_4278.

Structurei

3D structure databases

ProteinModelPortaliQ123X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E26. Bacteria.
COG2518. LUCA.
HOGENOMiHOG000257189.
KOiK00573.
OMAiGDGYHGW.
OrthoDBiPOG091H06AY.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q123X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEEITALVR ETRTETGKPA LDERVMAVMG KVPRHEFVPA DQLPRAYQNR
60 70 80 90 100
PLPIGHGQTI SQPYIVALMT DLARVEPGHK VLEVGTGSGY QAAVMAHLAR
110 120 130 140 150
AVYTIEIIEP LGLQARQRLQ KLGYDNVQVR LGDGYHGWEE HAPYDAILVT
160 170 180 190 200
AAASHIPPPL IRQLKAGGRM VIPVGAAFMV QQLMLVEKNR DGTVSTRQIL
210
PVAFVPLTGQ R
Length:211
Mass (Da):23,226
Last modified:August 22, 2006 - v1
Checksum:iA050B1BEC89513B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000316 Genomic DNA. Translation: ABE46170.1.

Genome annotation databases

EnsemblBacteriaiABE46170; ABE46170; Bpro_4278.
KEGGipol:Bpro_4278.
PATRICi22961828. VBIPolSp102244_4362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000316 Genomic DNA. Translation: ABE46170.1.

3D structure databases

ProteinModelPortaliQ123X2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi296591.Bpro_4278.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABE46170; ABE46170; Bpro_4278.
KEGGipol:Bpro_4278.
PATRICi22961828. VBIPolSp102244_4362.

Phylogenomic databases

eggNOGiENOG4105E26. Bacteria.
COG2518. LUCA.
HOGENOMiHOG000257189.
KOiK00573.
OMAiGDGYHGW.
OrthoDBiPOG091H06AY.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIMT2_POLSJ
AccessioniPrimary (citable) accession number: Q123X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: August 22, 2006
Last modified: November 2, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.