ID   GST2_YEAST              Reviewed;         233 AA.
AC   Q12390;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   16-JUN-2009, entry version 72.
DE   RecName: Full=Glutathione S-transferase 2;
DE            EC=2.5.1.18;
DE   AltName: Full=GST-II;
GN   Name=GTT2; OrderedLocusNames=YLL060C; ORFNames=L0560;
OS   Saccharomyces cerevisiae (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=4932;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204511 / S288c / AB972;
RA   Wedler H., Wambutt R.;
RT   "Sequence of a 37 kb DNA fragment from chromosome XII of Saccharomyces
RT   cerevisiae including the subtelomeric region of the left arm.";
RL   Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204511 / S288c / AB972;
RX   MEDLINE=97313267; PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B.,
RA   Ansorge W., Benes V., Brueckner M., Delius H., Dubois E.,
RA   Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U.,
RA   Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K.,
RA   Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T.,
RA   Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E.,
RA   Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M.,
RA   Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C.,
RA   Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M.,
RA   Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H.,
RA   Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A.,
RA   Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A.,
RA   Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F.,
RA   Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G.,
RA   Kolodner R.D., LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-
RT   encoding clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   CHARACTERIZATION.
RX   MEDLINE=99009110; PubMed=9792709; DOI=10.1074/jbc.273.45.29915;
RA   Choi J.H., Lou W., Vancura A.;
RT   "A novel membrane-bound glutathione S-transferase functions in the
RT   stationary phase of the yeast Saccharomyces cerevisiae.";
RL   J. Biol. Chem. 273:29915-29922(1998).
CC   -!- CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the GST superfamily.
CC   -!- SIMILARITY: Contains 1 GST C-terminal domain.
CC   -!- SIMILARITY: Contains 1 GST N-terminal domain.
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DR   EMBL; Z47973; CAA87997.1; -; Genomic_DNA.
DR   EMBL; Z73165; CAA97513.1; -; Genomic_DNA.
DR   EMBL; AY557940; AAS56266.1; -; Genomic_DNA.
DR   PIR; S50960; S50960.
DR   RefSeq; NP_013040.1; -.
DR   HSSP; Q9ZVQ3; 1E6B.
DR   DIP; DIP:2981N; -.
DR   IntAct; Q12390; 3.
DR   PeptideAtlas; Q12390; -.
DR   Ensembl; YLL060C; Saccharomyces cerevisiae.
DR   GeneID; 850666; -.
DR   GenomeReviews; Y13138_GR; YLL060C.
DR   KEGG; sce:YLL060C; -.
DR   NMPDR; fig|4932.3.peg.4031; -.
DR   CYGD; YLL060c; -.
DR   SGD; S000003983; GTT2.
DR   HOGENOM; Q12390; -.
DR   OMA; Q12390; CEALRAW.
DR   BRENDA; 2.5.1.18; 250.
DR   NextBio; 966644; -.
DR   GermOnline; YLL060C; Saccharomyces cerevisiae.
DR   GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR   GO; GO:0004364; F:glutathione transferase activity; IDA:SGD.
DR   GO; GO:0006749; P:glutathione metabolic process; IDA:SGD.
DR   GO; GO:0009636; P:response to toxin; IEP:SGD.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:1.20.1050.10; GST_C_like; 1.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Transferase.
FT   CHAIN         1    233       Glutathione S-transferase 2.
FT                                /FTId=PRO_0000185988.
FT   DOMAIN       17    101       GST N-terminal.
FT   DOMAIN      106    233       GST C-terminal.
SQ   SEQUENCE   233 AA;  26340 MW;  B5EE0E47D5A37175 CRC64;
     MNGRGFLIYN GGEKMKQKMI IYDTPAGPYP ARVRIALAEK NMLSSVQFVR INLWKGEHKK
     PEFLAKNYSG TVPVLELDDG TLIAECTAIT EYIDALDGTP TLTGKTPLEK GVIHMMNKRA
     ELELLDPVSV YFHHATPGLG PEVELYQNKE WGLRQRDKAL HGMHYFDTVL RERPYVAGDS
     FSMADITVIA GLIFAAIVKL QVPEECEALR AWYKRMQQRP SVKKLLEIRS KSS
//