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Protein

N-terminal acetyltransferase B complex subunit MDM20

Gene

MDM20

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met. NatB acetylates TPM1 protein and regulates tropomyocin-actin interactions. MDM20 is required for mitochondrial inheritance during budding and together with TPM1, is essential for the integrity and assembly of actin cables. Genetically interacts with CIN8.3 Publications

Miscellaneous

Present with 5800 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • cytoskeleton organization Source: SGD
  • mitochondrion inheritance Source: SGD
  • N-terminal peptidyl-methionine acetylation Source: SGD
  • regulation of actin cytoskeleton organization Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-33480-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
N-terminal acetyltransferase B complex subunit MDM20
Short name:
NatB complex subunit MDM20
Alternative name(s):
Dislikes extra CIN8 protein 1
Mitochondrial distribution and morphology protein 20
Gene namesi
Name:MDM20
Synonyms:DEC1
Ordered Locus Names:YOL076W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL076W.
SGDiS000005436. MDM20.

Subcellular locationi

GO - Cellular componenti

  • NatB complex Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000798502 – 796N-terminal acetyltransferase B complex subunit MDM20Add BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ12387.
PRIDEiQ12387.

PTM databases

iPTMnetiQ12387.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase B (NatB) complex, which is composed of NAT3 and MDM20.1 Publication

Protein-protein interaction databases

BioGridi34326. 170 interactors.
IntActiQ12387. 1 interactor.
MINTiMINT-1164738.
STRINGi4932.YOL076W.

Structurei

3D structure databases

ProteinModelPortaliQ12387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MDM20/NAA25 family.Curated

Phylogenomic databases

HOGENOMiHOG000113510.
InParanoidiQ12387.
KOiK17973.
OMAiRDFKSEW.
OrthoDBiEOG092C2IZB.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR019183. N-acetylTrfase_B_cplx_non-cat.
IPR011990. TPR-like_helical_dom.
PANTHERiPTHR22767:SF8. PTHR22767:SF8. 1 hit.
PfamiView protein in Pfam
PF09797. NatB_MDM20. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKIQEEIL GLVSRSNFKQ CYAKLGQLQK QFPNALYFKI LETYVKFKQS
60 70 80 90 100
PGKFDYNKLL EEPYGLKGTT ITGDTRSLEF LHNFFVELGK YDEALHVYER
110 120 130 140 150
GNFKFPSYEL SYHWFMKALE DSNYNQMSKA SLQLAKYSDS GNLPKRAYYF
160 170 180 190 200
WNAISILAVS RFQENTLSDP KKILLSRLAR QSLLDLKPFQ NVQEIIVYCL
210 220 230 240 250
VLDELFPQSR EISEEIVAIT FANFDTSVNL YLKNFILKHT KLLNSPQKLF
260 270 280 290 300
EVCSKLIEKG LDDYELITNL IDAAYKLSKS KDEVKQWIDE NLGDSRNTRL
310 320 330 340 350
ARLKLDIMYT DSVSESSLSY YLSKYHNKPC CSIDLNHYSG HINIDMLKSI
360 370 380 390 400
MSKYDPEDKD LIHHCNILEL GLIGSDSINN YNKFKGTLEK KSVTDYSSCS
410 420 430 440 450
TFLLEIVKDK CKKTNPELKD VLLCITILEN YQAKDPHNFD TMCWLIVLYM
460 470 480 490 500
YLGLVPDAYF HFINLKIKNV QTDSLDYMIF SRFSTLFPNK QSDFYSKTFH
510 520 530 540 550
EHNNLYDTSL ANLPRYIQVA FERNSYSKIL GMLEMRDKLM KSYTRWTKTL
560 570 580 590 600
ENLQFSRLCN DKRGHLLQKL HEDWRSLEMT QSVSFSDNRD FSILDENFAQ
610 620 630 640 650
FLNRGKILEY ANLNEESIFL TLIRELIIEA LPNGEKTEQI SALLKKLPSI
660 670 680 690 700
NLEELLNNNL TEVESASFLI FFEIYENNGK NLHDLISRLM KVPINAKQNW
710 720 730 740 750
MVSHTYLTKM ATLKTLDSLK RIKDKEIQKL IKNSLKELRS CCDDVFKGYS
760 770 780 790
KALVQAYEEL KKDECGNLLK ELDVKAENVK NIKNSLLGIQ KSVRNL
Length:796
Mass (Da):92,809
Last modified:November 1, 1997 - v1
Checksum:i30E57DB1B12DCD2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36382 Genomic DNA. Translation: AAA79781.1.
U54799 Genomic DNA. Translation: AAB00196.1.
Z74818 Genomic DNA. Translation: CAA99086.1.
AY693080 Genomic DNA. Translation: AAT93099.1.
BK006948 Genomic DNA. Translation: DAA10708.1.
PIRiS66769.
RefSeqiNP_014566.1. NM_001183330.1.

Genome annotation databases

EnsemblFungiiYOL076W; YOL076W; YOL076W.
GeneIDi854079.
KEGGisce:YOL076W.

Similar proteinsi

Entry informationi

Entry nameiNAA25_YEAST
AccessioniPrimary (citable) accession number: Q12387
Secondary accession number(s): D6W1Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names