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Protein

1-acylglycerol-3-phosphate O-acyltransferase ICT1

Gene

ICT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Lysophosphatidic acid acyltransferase involved in membrane remodeling leading to increased organic solvent tolerance. Involved in resistance to azoles and copper.4 Publications

Miscellaneous

The isooctane tolerance of organic-solvent tolerant strain KK-21 may result from the alteration of the expression of several genes including ICT1, due to the loss of their proper regulation.

Catalytic activityi

Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

  • phosphatidic acid biosynthetic process Source: SGD

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism, Stress response

Enzyme and pathway databases

BioCyciYEAST:G3O-32249-MONOMER
ReactomeiR-SCE-1482839 Acyl chain remodelling of PE

Protein family/group databases

ESTHERiyeast-ict1 CGI-58_ABHD5_ABHD4
MEROPSiS33.A43

Names & Taxonomyi

Protein namesi
Recommended name:
1-acylglycerol-3-phosphate O-acyltransferase ICT1 (EC:2.3.1.51)
Alternative name(s):
Increased copper tolerance protein 1
Lysophosphatidic acid acyltransferase ICT1
Short name:
LPAAT
Gene namesi
Name:ICT1
Ordered Locus Names:YLR099C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR099C
SGDiS000004089 ICT1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000808541 – 3941-acylglycerol-3-phosphate O-acyltransferase ICT1Add BLAST394

Proteomic databases

PaxDbiQ12385
PRIDEiQ12385

Interactioni

Protein-protein interaction databases

BioGridi31372, 75 interactors
DIPiDIP-5245N
IntActiQ12385, 2 interactors
STRINGi4932.YLR099C

Structurei

3D structure databases

ProteinModelPortaliQ12385
SMRiQ12385
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 381AB hydrolase-1Sequence analysisAdd BLAST308

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi374 – 379HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000016277
HOGENOMiHOG000065957
InParanoidiQ12385
KOiK13699
OMAiKAPEDWE
OrthoDBiEOG092C49VO

Family and domain databases

Gene3Di3.40.50.1820, 2 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PRINTSiPR00111 ABHYDROLASE
SUPFAMiSSF53474 SSF53474, 2 hits

Sequencei

Sequence statusi: Complete.

Q12385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTNTFKWCS KTEKETTTAD AKVCASVQGL KALQQQIMDS TTVRGSVNNT
60 70 80 90 100
MTPGGINQWH FHNKRANKVC TPTVLIHGYA ASSMAFYRTF ENLSDNIKDL
110 120 130 140 150
YAIDLPANGA SEAPALQVNK TKKIKSLRFK HIEDDVVIPV IEKRPPAEDI
160 170 180 190 200
KSHLEQYESY FVDRIEQWRK DNKLRKINVV GHSFGGYISF KYALKYPDSI
210 220 230 240 250
EKLCLISPLG VENSIHAITH KWEPNTTYPL TFTDPSSRYY TRKLNVPRFI
260 270 280 290 300
FENQLNVLKW MGPIGSKLCS NYISTAYVKV PDQIYKDYLL HSFVGKNQTV
310 320 330 340 350
QPQTIKVFTH LFERNLIARD PIINNVRFLN PATPVMFMYG EHDWMDKYAG
360 370 380 390
YLTTESMLKN KAKASYVEVP DAGHNLFLDN PQHFASSLVS FLSK
Length:394
Mass (Da):45,141
Last modified:November 1, 1996 - v1
Checksum:i7B686E611E81C380
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73271 Genomic DNA Translation: CAA97663.1
Z73272 Genomic DNA Translation: CAA97666.1
U53876 Genomic DNA Translation: AAB67543.1
BK006945 Genomic DNA Translation: DAA09415.1
PIRiS64933
RefSeqiNP_013200.1, NM_001181986.1

Genome annotation databases

EnsemblFungiiYLR099C; YLR099C; YLR099C
GeneIDi850788
KEGGisce:YLR099C

Similar proteinsi

Entry informationi

Entry nameiICT1_YEAST
AccessioniPrimary (citable) accession number: Q12385
Secondary accession number(s): D6VY99, Q7LGX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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