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Q12378

- RTR2_YEAST

UniProt

Q12378 - RTR2_YEAST

Protein

RNA polymerase II subunit B1 CTD phosphatase RTR2

Gene

RTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Probable RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that regulates RNA polymerase II transcription. May have functional redundancy with RTR1.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri52 – 12372RTR1-typeAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29673-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase II subunit B1 CTD phosphatase RTR2 (EC:3.1.3.16)
    Alternative name(s):
    RNA polymerase II-associated protein 2 homolog RTR2
    Regulator of transcription 2
    Gene namesi
    Name:RTR2
    Ordered Locus Names:YDR066C
    ORF Names:D4261
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR066c.
    SGDiS000002473. RTR2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 196196RNA polymerase II subunit B1 CTD phosphatase RTR2PRO_0000244439Add
    BLAST

    Proteomic databases

    PaxDbiQ12378.

    Expressioni

    Gene expression databases

    GenevestigatoriQ12378.

    Interactioni

    Protein-protein interaction databases

    BioGridi32121. 6 interactions.
    DIPiDIP-5708N.
    MINTiMINT-564231.
    STRINGi4932.YDR066C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ12378.
    SMRiQ12378. Positions 9-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RPAP2 family.Curated
    Contains 1 RTR1-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri52 – 12372RTR1-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG315830.
    GeneTreeiENSGT00530000069589.
    OMAiSIVEARM.
    OrthoDBiEOG7TXKVF.

    Family and domain databases

    InterProiIPR007308. DUF408.
    [Graphical view]
    PfamiPF04181. RPAP2_Rtr1. 1 hit.
    [Graphical view]
    PROSITEiPS51479. ZF_RTR1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q12378-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQIITTTFIQ KVILGSHQLH EQLSIVEARM IESAIVSMLT ESFCENEQTL    50
    KYLARLLSPM SYMDVINARR GKKICGYPLC YKSAAENSSD GFFIHSMYCN 100
    NYHSKCSLYL MRQLSQTPLH ERRGVHLTSY INLEFDDMYS VSLLEELVGS 150
    EVPIDTVKSL ITSFKDLEFD DTYKNEPLPL DVYFGQLTTD EETCIE 196
    Length:196
    Mass (Da):22,541
    Last modified:November 1, 1996 - v1
    Checksum:iE6FA7F6F40C1C517
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84162 Genomic DNA. Translation: CAA58982.1.
    Z49209 Genomic DNA. Translation: CAA89095.1.
    Z74362 Genomic DNA. Translation: CAA98884.1.
    BK006938 Genomic DNA. Translation: DAA11912.1.
    PIRiS54050.
    RefSeqiNP_010351.1. NM_001180374.1.

    Genome annotation databases

    EnsemblFungiiYDR066C; YDR066C; YDR066C.
    GeneIDi851638.
    KEGGisce:YDR066C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84162 Genomic DNA. Translation: CAA58982.1 .
    Z49209 Genomic DNA. Translation: CAA89095.1 .
    Z74362 Genomic DNA. Translation: CAA98884.1 .
    BK006938 Genomic DNA. Translation: DAA11912.1 .
    PIRi S54050.
    RefSeqi NP_010351.1. NM_001180374.1.

    3D structure databases

    ProteinModelPortali Q12378.
    SMRi Q12378. Positions 9-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32121. 6 interactions.
    DIPi DIP-5708N.
    MINTi MINT-564231.
    STRINGi 4932.YDR066C.

    Proteomic databases

    PaxDbi Q12378.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR066C ; YDR066C ; YDR066C .
    GeneIDi 851638.
    KEGGi sce:YDR066C.

    Organism-specific databases

    CYGDi YDR066c.
    SGDi S000002473. RTR2.

    Phylogenomic databases

    eggNOGi NOG315830.
    GeneTreei ENSGT00530000069589.
    OMAi SIVEARM.
    OrthoDBi EOG7TXKVF.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29673-MONOMER.

    Miscellaneous databases

    NextBioi 969200.

    Gene expression databases

    Genevestigatori Q12378.

    Family and domain databases

    InterProi IPR007308. DUF408.
    [Graphical view ]
    Pfami PF04181. RPAP2_Rtr1. 1 hit.
    [Graphical view ]
    PROSITEi PS51479. ZF_RTR1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence analysis of a 32,500 bp region of the right arm of Saccharomyces cerevisiae chromosome IV."
      Brandt P., Ramlow S., Otto B., Bloecker H.
      Yeast 12:85-90(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins."
      Gibney P.A., Fries T., Bailer S.M., Morano K.A.
      Eukaryot. Cell 7:938-948(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: ZINC-FINGER, FUNCTION.

    Entry informationi

    Entry nameiRTR2_YEAST
    AccessioniPrimary (citable) accession number: Q12378
    Secondary accession number(s): D6VS52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1050 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3