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Q12378

- RTR2_YEAST

UniProt

Q12378 - RTR2_YEAST

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Protein

RNA polymerase II subunit B1 CTD phosphatase RTR2

Gene

RTR2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Probable RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that regulates RNA polymerase II transcription. May have functional redundancy with RTR1.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri52 – 12372RTR1-typeAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-29673-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit B1 CTD phosphatase RTR2 (EC:3.1.3.16)
Alternative name(s):
RNA polymerase II-associated protein 2 homolog RTR2
Regulator of transcription 2
Gene namesi
Name:RTR2
Ordered Locus Names:YDR066C
ORF Names:D4261
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR066c.
SGDiS000002473. RTR2.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196RNA polymerase II subunit B1 CTD phosphatase RTR2PRO_0000244439Add
BLAST

Proteomic databases

PaxDbiQ12378.

Expressioni

Gene expression databases

GenevestigatoriQ12378.

Interactioni

Protein-protein interaction databases

BioGridi32121. 6 interactions.
DIPiDIP-5708N.
MINTiMINT-564231.
STRINGi4932.YDR066C.

Structurei

3D structure databases

ProteinModelPortaliQ12378.
SMRiQ12378. Positions 9-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RPAP2 family.Curated
Contains 1 RTR1-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri52 – 12372RTR1-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG315830.
GeneTreeiENSGT00530000069589.
InParanoidiQ12378.
OMAiSIVEARM.
OrthoDBiEOG7TXKVF.

Family and domain databases

InterProiIPR007308. DUF408.
[Graphical view]
PfamiPF04181. RPAP2_Rtr1. 1 hit.
[Graphical view]
PROSITEiPS51479. ZF_RTR1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12378-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQIITTTFIQ KVILGSHQLH EQLSIVEARM IESAIVSMLT ESFCENEQTL
60 70 80 90 100
KYLARLLSPM SYMDVINARR GKKICGYPLC YKSAAENSSD GFFIHSMYCN
110 120 130 140 150
NYHSKCSLYL MRQLSQTPLH ERRGVHLTSY INLEFDDMYS VSLLEELVGS
160 170 180 190
EVPIDTVKSL ITSFKDLEFD DTYKNEPLPL DVYFGQLTTD EETCIE
Length:196
Mass (Da):22,541
Last modified:November 1, 1996 - v1
Checksum:iE6FA7F6F40C1C517
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84162 Genomic DNA. Translation: CAA58982.1.
Z49209 Genomic DNA. Translation: CAA89095.1.
Z74362 Genomic DNA. Translation: CAA98884.1.
BK006938 Genomic DNA. Translation: DAA11912.1.
PIRiS54050.
RefSeqiNP_010351.1. NM_001180374.1.

Genome annotation databases

EnsemblFungiiYDR066C; YDR066C; YDR066C.
GeneIDi851638.
KEGGisce:YDR066C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84162 Genomic DNA. Translation: CAA58982.1 .
Z49209 Genomic DNA. Translation: CAA89095.1 .
Z74362 Genomic DNA. Translation: CAA98884.1 .
BK006938 Genomic DNA. Translation: DAA11912.1 .
PIRi S54050.
RefSeqi NP_010351.1. NM_001180374.1.

3D structure databases

ProteinModelPortali Q12378.
SMRi Q12378. Positions 9-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32121. 6 interactions.
DIPi DIP-5708N.
MINTi MINT-564231.
STRINGi 4932.YDR066C.

Proteomic databases

PaxDbi Q12378.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR066C ; YDR066C ; YDR066C .
GeneIDi 851638.
KEGGi sce:YDR066C.

Organism-specific databases

CYGDi YDR066c.
SGDi S000002473. RTR2.

Phylogenomic databases

eggNOGi NOG315830.
GeneTreei ENSGT00530000069589.
InParanoidi Q12378.
OMAi SIVEARM.
OrthoDBi EOG7TXKVF.

Enzyme and pathway databases

BioCyci YEAST:G3O-29673-MONOMER.

Miscellaneous databases

NextBioi 969200.

Gene expression databases

Genevestigatori Q12378.

Family and domain databases

InterProi IPR007308. DUF408.
[Graphical view ]
Pfami PF04181. RPAP2_Rtr1. 1 hit.
[Graphical view ]
PROSITEi PS51479. ZF_RTR1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence analysis of a 32,500 bp region of the right arm of Saccharomyces cerevisiae chromosome IV."
    Brandt P., Ramlow S., Otto B., Bloecker H.
    Yeast 12:85-90(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins."
    Gibney P.A., Fries T., Bailer S.M., Morano K.A.
    Eukaryot. Cell 7:938-948(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ZINC-FINGER, FUNCTION.

Entry informationi

Entry nameiRTR2_YEAST
AccessioniPrimary (citable) accession number: Q12378
Secondary accession number(s): D6VS52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1050 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3