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Q12375 (ORT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial ornithine transporter 1
Gene names
Name:ORT1
Synonyms:ARG11
Ordered Locus Names:YOR130C
ORF Names:O3299, YOR3299C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for arginine biosynthesis. Transports ornithine synthesized from glutamate in the mitochondrial matrix to the cytosol, where it is converted to arginine. Ref.6

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Ref.7.

Miscellaneous

Present with 432 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Mitochondrial ornithine transporter 1
PRO_0000090684

Regions

Transmembrane14 – 3421Helical; Name=1; Potential
Transmembrane69 – 8921Helical; Name=2; Potential
Transmembrane104 – 12421Helical; Name=3; Potential
Transmembrane171 – 18717Helical; Name=4; Potential
Transmembrane213 – 23321Helical; Name=5; Potential
Transmembrane267 – 28721Helical; Name=6; Potential
Repeat11 – 9787Solcar 1
Repeat105 – 19692Solcar 2
Repeat211 – 29282Solcar 3

Experimental info

Sequence conflict1051S → F in CAA62118. Ref.2
Sequence conflict1051S → F in CAA64049. Ref.3
Sequence conflict1051S → F in CAA99329. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q12375 [UniParc].

Last modified September 21, 2011. Version 2.
Checksum: 3B80DDCC5875FD66

FASTA29231,520
        10         20         30         40         50         60 
MEDSKKKGLI EGAILDIING SIAGACGKVI EFPFDTVKVR LQTQASNVFP TTWSCIKFTY 

        70         80         90        100        110        120 
QNEGIARGFF QGIASPLVGA CLENATLFVS YNQCSKFLEK HTNVSPLGQI LISGGVAGSC 

       130        140        150        160        170        180 
ASLVLTPVEL VKCKLQVANL QVASAKTKHT KVLPTIKAII TERGLAGLWQ GQSGTFIRES 

       190        200        210        220        230        240 
FGGVAWFATY EIVKKSLKDR HSLDDPKRDE SKIWELLISG GSAGLAFNAS IFPADTVKSV 

       250        260        270        280        290 
MQTEHISLTN AVKKIFGKFG LKGFYRGLGI TLFRAVPANA AVFYIFETLS AL

« Hide

References

« Hide 'large scale' references
[1]"The ARG11 gene of Saccharomyces cerevisiae encodes a mitochondrial integral membrane protein required for arginine biosynthesis."
Crabeel M., Soetens O., de Rijcke M., Pratiwi R., Pankiewicz R.
J. Biol. Chem. 271:25011-25018(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
Strain: ATCC 28383 / FL100 / VTT C-80102.
[2]"Sequencing and analysis of 51 kb on the right arm of chromosome XV from Saccharomyces cerevisiae reveals 30 open reading frames."
Wiemann S., Rechmann S., Benes V., Voss H., Schwager C., Vlcek C., Stegemann J., Zimmermann J., Erfle H., Paces V., Ansorge W.
Yeast 12:281-288(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[3]"DNA sequencing and analysis of 130 kb from yeast chromosome XV."
Voss H., Benes V., Andrade M.A., Valencia A., Rechmann S., Teodoru C., Schwager C., Paces V., Sander C., Ansorge W.
Yeast 13:655-672(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. expand/collapse author list , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 96604 / S288c / FY1679.
[5]Saccharomyces Genome Database
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 105.
Strain: ATCC 204508 / S288c.
[6]"Identification of the yeast ARG-11 gene as a mitochondrial ornithine carrier involved in arginine biosynthesis."
Palmieri L., De Marco V., Iacobazzi V., Palmieri F., Runswick M.J., Walker J.E.
FEBS Lett. 410:447-451(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X87414 Genomic DNA. Translation: CAA60862.1.
X90518 Genomic DNA. Translation: CAA62118.1.
X94335 Genomic DNA. Translation: CAA64049.1.
Z75038 Genomic DNA. Translation: CAA99329.1.
BK006948 Genomic DNA. Translation: DAA10904.2.
PIRS60997.
RefSeqNP_014773.4. NM_001183549.4.

3D structure databases

ProteinModelPortalQ12375.
SMRQ12375. Positions 17-292.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-8953N.
MINTMINT-2493498.
STRING4932.YOR130C.

Protein family/group databases

TCDB2.A.29.9.2. mitochondrial carrier (MC) family.

Proteomic databases

PaxDbQ12375.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYOR130C; YOR130C; YOR130C.
GeneID854297.
KEGGsce:YOR130C.

Organism-specific databases

CYGDYOR130c.
SGDS000005656. ORT1.

Phylogenomic databases

eggNOGNOG245037.
GeneTreeENSGT00640000092016.
HOGENOMHOG000168307.
KOK15114.
OMASRKMMMN.
OrthoDBEOG4B5SF2.

Enzyme and pathway databases

BioCycYEAST:G3O-33654-MONOMER.

Gene expression databases

GenevestigatorQ12375.
GermOnlineYOR130C. Saccharomyces cerevisiae.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMSSF103506. Mitoch_carrier. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio976296.

Entry information

Entry nameORT1_YEAST
AccessionPrimary (citable) accession number: Q12375
Secondary accession number(s): D6W2I8, Q92273
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 21, 2011
Last modified: May 29, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XV

Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents