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Protein

Mitochondrial ornithine transporter 1

Gene

ORT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for arginine biosynthesis. Transports ornithine synthesized from glutamate in the mitochondrial matrix to the cytosol, where it is converted to arginine.1 Publication

GO - Molecular functioni

  • L-ornithine transmembrane transporter activity Source: SGD

GO - Biological processi

  • arginine biosynthetic process Source: SGD
  • mitochondrial ornithine transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33654-MONOMER.
ReactomeiR-SCE-70635. Urea cycle.

Protein family/group databases

TCDBi2.A.29.9.2. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial ornithine transporter 1
Gene namesi
Name:ORT1
Synonyms:ARG11
Ordered Locus Names:YOR130C
ORF Names:O3299, YOR3299C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR130C.
SGDiS000005656. ORT1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei171 – 187Helical; Name=4Sequence analysisAdd BLAST17
Transmembranei213 – 233Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei267 – 287Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial envelope Source: SGD
  • mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000906841 – 292Mitochondrial ornithine transporter 1Add BLAST292

Proteomic databases

MaxQBiQ12375.
PRIDEiQ12375.

Interactioni

Protein-protein interaction databases

BioGridi34525. 22 interactors.
DIPiDIP-8953N.
MINTiMINT-2493498.

Structurei

3D structure databases

ProteinModelPortaliQ12375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 97Solcar 1Add BLAST87
Repeati105 – 196Solcar 2Add BLAST92
Repeati211 – 292Solcar 3Add BLAST82

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00730000110966.
HOGENOMiHOG000168307.
InParanoidiQ12375.
KOiK15114.
OMAiVIREVWH.
OrthoDBiEOG092C3A14.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSKKKGLI EGAILDIING SIAGACGKVI EFPFDTVKVR LQTQASNVFP
60 70 80 90 100
TTWSCIKFTY QNEGIARGFF QGIASPLVGA CLENATLFVS YNQCSKFLEK
110 120 130 140 150
HTNVSPLGQI LISGGVAGSC ASLVLTPVEL VKCKLQVANL QVASAKTKHT
160 170 180 190 200
KVLPTIKAII TERGLAGLWQ GQSGTFIRES FGGVAWFATY EIVKKSLKDR
210 220 230 240 250
HSLDDPKRDE SKIWELLISG GSAGLAFNAS IFPADTVKSV MQTEHISLTN
260 270 280 290
AVKKIFGKFG LKGFYRGLGI TLFRAVPANA AVFYIFETLS AL
Length:292
Mass (Da):31,520
Last modified:September 21, 2011 - v2
Checksum:i3B80DDCC5875FD66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105S → F in CAA62118 (PubMed:8904341).Curated1
Sequence conflicti105S → F in CAA64049 (PubMed:9200815).Curated1
Sequence conflicti105S → F in CAA99329 (PubMed:9169874).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87414 Genomic DNA. Translation: CAA60862.1.
X90518 Genomic DNA. Translation: CAA62118.1.
X94335 Genomic DNA. Translation: CAA64049.1.
Z75038 Genomic DNA. Translation: CAA99329.1.
BK006948 Genomic DNA. Translation: DAA10904.2.
PIRiS60997.
RefSeqiNP_014773.4. NM_001183549.4.

Genome annotation databases

EnsemblFungiiYOR130C; YOR130C; YOR130C.
GeneIDi854297.
KEGGisce:YOR130C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87414 Genomic DNA. Translation: CAA60862.1.
X90518 Genomic DNA. Translation: CAA62118.1.
X94335 Genomic DNA. Translation: CAA64049.1.
Z75038 Genomic DNA. Translation: CAA99329.1.
BK006948 Genomic DNA. Translation: DAA10904.2.
PIRiS60997.
RefSeqiNP_014773.4. NM_001183549.4.

3D structure databases

ProteinModelPortaliQ12375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34525. 22 interactors.
DIPiDIP-8953N.
MINTiMINT-2493498.

Protein family/group databases

TCDBi2.A.29.9.2. the mitochondrial carrier (mc) family.

Proteomic databases

MaxQBiQ12375.
PRIDEiQ12375.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR130C; YOR130C; YOR130C.
GeneIDi854297.
KEGGisce:YOR130C.

Organism-specific databases

EuPathDBiFungiDB:YOR130C.
SGDiS000005656. ORT1.

Phylogenomic databases

GeneTreeiENSGT00730000110966.
HOGENOMiHOG000168307.
InParanoidiQ12375.
KOiK15114.
OMAiVIREVWH.
OrthoDBiEOG092C3A14.

Enzyme and pathway databases

BioCyciYEAST:G3O-33654-MONOMER.
ReactomeiR-SCE-70635. Urea cycle.

Miscellaneous databases

PROiQ12375.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiORT1_YEAST
AccessioniPrimary (citable) accession number: Q12375
Secondary accession number(s): D6W2I8, Q92273
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 21, 2011
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 432 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.