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Protein

HAT1-interacting factor 1

Gene

HIF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Histone H3 and H4 specific chaperone component of the nuclear histone acetyltransferase B (HAT-B) complex. Involved in chromatin assembly and telomere silencing.2 Publications

GO - Molecular functioni

  • histone binding Source: SGD

GO - Biological processi

  • chromatin silencing at telomere Source: SGD
  • histone acetylation Source: SGD
  • nucleosome assembly Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32126-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HAT1-interacting factor 1
Gene namesi
Name:HIF1
Ordered Locus Names:YLL022C
ORF Names:L1205
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL022C.
SGDiS000003945. HIF1.

Subcellular locationi

GO - Cellular componenti

  • chromosome, telomeric region Source: GOC
  • histone acetyltransferase complex Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277311 – 385HAT1-interacting factor 1Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12373.
PRIDEiQ12373.

PTM databases

iPTMnetiQ12373.

Interactioni

Subunit structurei

Component of the nuclear histone acetyltransferase B (HAT-B) complex composed of at least HAT1, HAT2 and HIF1. Interacts with histones H3 and H4 in a HAT1/HAT2 dependent manner.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HAT2P399843EBI-31911,EBI-8185
HHF2P023095EBI-31911,EBI-8113

GO - Molecular functioni

  • histone binding Source: SGD

Protein-protein interaction databases

BioGridi31231. 38 interactors.
DIPiDIP-6442N.
IntActiQ12373. 6 interactors.
MINTiMINT-473929.

Structurei

Secondary structure

1385
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 34Combined sources21
Helixi38 – 51Combined sources14
Beta strandi54 – 56Combined sources3
Helixi61 – 77Combined sources17
Helixi161 – 163Combined sources3
Helixi167 – 171Combined sources5
Helixi186 – 188Combined sources3
Helixi194 – 198Combined sources5
Helixi202 – 218Combined sources17
Helixi229 – 248Combined sources20
Helixi252 – 266Combined sources15
Helixi273 – 290Combined sources18
Helixi298 – 316Combined sources19
Helixi323 – 342Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NQ0X-ray2.10A1-385[»]
ProteinModelPortaliQ12373.
SMRiQ12373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati186 – 220TPR 1Add BLAST35
Repeati229 – 262TPR 2Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi97 – 184Glu-richAdd BLAST88

Sequence similaritiesi

Belongs to the NASP family.Curated
Contains 2 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

InParanoidiQ12373.
KOiK11372.
OMAiHIYFEND.
OrthoDBiEOG092C5ND8.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR011990. TPR-like_helical_dom.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRAEDVLA NGTSRHKVQI DMERQVQIAK DLLAQKKFLE AAKRCQQTLD
60 70 80 90 100
SLPKDGLLPD PELFTIFAQA VYNMEVQNSG NLFGDALLAG DDGSGSESES
110 120 130 140 150
EPESDVSNGE EGNENGQTEI PNSRMFQFDQ EEEDLTGDVD SGDSEDSGEG
160 170 180 190 200
SEEEEENVEK EEERLALHEL ANFSPANEHD DEIEDVSQLR KSGFHIYFEN
210 220 230 240 250
DLYENALDLL AQALMLLGRP TADGQSLTEN SRLRIGDVYI LMGDIEREAE
260 270 280 290 300
MFSRAIHHYL KALGYYKTLK PAEQVTEKVI QAEFLVCDAL RWVDQVPAKD
310 320 330 340 350
KLKRFKHAKA LLEKHMTTRP KDSELQQARL AQIQDDIDEV QENQQHGSKR
360 370 380
PLSQPTTSIG FPALEKPLGD FNDLSQLVKK KPRRH
Length:385
Mass (Da):43,428
Last modified:November 1, 1996 - v1
Checksum:iB280CFCCB6896506
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97560 Genomic DNA. Translation: CAA66169.1.
Z73127 Genomic DNA. Translation: CAA97470.1.
BK006945 Genomic DNA. Translation: DAA09298.1.
PIRiS64770.
RefSeqiNP_013078.1. NM_001181842.1.

Genome annotation databases

EnsemblFungiiYLL022C; YLL022C; YLL022C.
GeneIDi850638.
KEGGisce:YLL022C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97560 Genomic DNA. Translation: CAA66169.1.
Z73127 Genomic DNA. Translation: CAA97470.1.
BK006945 Genomic DNA. Translation: DAA09298.1.
PIRiS64770.
RefSeqiNP_013078.1. NM_001181842.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NQ0X-ray2.10A1-385[»]
ProteinModelPortaliQ12373.
SMRiQ12373.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31231. 38 interactors.
DIPiDIP-6442N.
IntActiQ12373. 6 interactors.
MINTiMINT-473929.

PTM databases

iPTMnetiQ12373.

Proteomic databases

MaxQBiQ12373.
PRIDEiQ12373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLL022C; YLL022C; YLL022C.
GeneIDi850638.
KEGGisce:YLL022C.

Organism-specific databases

EuPathDBiFungiDB:YLL022C.
SGDiS000003945. HIF1.

Phylogenomic databases

InParanoidiQ12373.
KOiK11372.
OMAiHIYFEND.
OrthoDBiEOG092C5ND8.

Enzyme and pathway databases

BioCyciYEAST:G3O-32126-MONOMER.

Miscellaneous databases

PROiQ12373.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR011990. TPR-like_helical_dom.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIF1_YEAST
AccessioniPrimary (citable) accession number: Q12373
Secondary accession number(s): D6VXY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4550 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.