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Protein

HAT1-interacting factor 1

Gene

HIF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Histone H3 and H4 specific chaperone component of the nuclear histone acetyltransferase B (HAT-B) complex. Involved in chromatin assembly and telomere silencing.2 Publications

GO - Molecular functioni

  • histone binding Source: SGD

GO - Biological processi

  • chromatin silencing at telomere Source: SGD
  • histone acetylation Source: SGD
  • nucleosome assembly Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32126-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HAT1-interacting factor 1
Gene namesi
Name:HIF1
Ordered Locus Names:YLL022C
ORF Names:L1205
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL022C.
SGDiS000003945. HIF1.

Subcellular locationi

GO - Cellular componenti

  • chromosome, telomeric region Source: GOC
  • histone acetyltransferase complex Source: SGD
  • nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385HAT1-interacting factor 1PRO_0000227731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei174 – 1741PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12373.
PeptideAtlasiQ12373.

PTM databases

iPTMnetiQ12373.

Interactioni

Subunit structurei

Component of the nuclear histone acetyltransferase B (HAT-B) complex composed of at least HAT1, HAT2 and HIF1. Interacts with histones H3 and H4 in a HAT1/HAT2 dependent manner.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HAT2P399843EBI-31911,EBI-8185
HHF2P023095EBI-31911,EBI-8113

GO - Molecular functioni

  • histone binding Source: SGD

Protein-protein interaction databases

BioGridi31231. 38 interactions.
DIPiDIP-6442N.
IntActiQ12373. 6 interactions.
MINTiMINT-473929.

Structurei

Secondary structure

1
385
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi14 – 3421Combined sources
Helixi38 – 5114Combined sources
Beta strandi54 – 563Combined sources
Helixi61 – 7717Combined sources
Helixi161 – 1633Combined sources
Helixi167 – 1715Combined sources
Helixi186 – 1883Combined sources
Helixi194 – 1985Combined sources
Helixi202 – 21817Combined sources
Helixi229 – 24820Combined sources
Helixi252 – 26615Combined sources
Helixi273 – 29018Combined sources
Helixi298 – 31619Combined sources
Helixi323 – 34220Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NQ0X-ray2.10A1-385[»]
ProteinModelPortaliQ12373.
SMRiQ12373. Positions 13-79, 160-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati186 – 22035TPR 1Add
BLAST
Repeati229 – 26234TPR 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi97 – 18488Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the NASP family.Curated
Contains 2 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

InParanoidiQ12373.
KOiK11372.
OrthoDBiEOG7VMPG8.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR011990. TPR-like_helical_dom.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12373-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRAEDVLA NGTSRHKVQI DMERQVQIAK DLLAQKKFLE AAKRCQQTLD
60 70 80 90 100
SLPKDGLLPD PELFTIFAQA VYNMEVQNSG NLFGDALLAG DDGSGSESES
110 120 130 140 150
EPESDVSNGE EGNENGQTEI PNSRMFQFDQ EEEDLTGDVD SGDSEDSGEG
160 170 180 190 200
SEEEEENVEK EEERLALHEL ANFSPANEHD DEIEDVSQLR KSGFHIYFEN
210 220 230 240 250
DLYENALDLL AQALMLLGRP TADGQSLTEN SRLRIGDVYI LMGDIEREAE
260 270 280 290 300
MFSRAIHHYL KALGYYKTLK PAEQVTEKVI QAEFLVCDAL RWVDQVPAKD
310 320 330 340 350
KLKRFKHAKA LLEKHMTTRP KDSELQQARL AQIQDDIDEV QENQQHGSKR
360 370 380
PLSQPTTSIG FPALEKPLGD FNDLSQLVKK KPRRH
Length:385
Mass (Da):43,428
Last modified:November 1, 1996 - v1
Checksum:iB280CFCCB6896506
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97560 Genomic DNA. Translation: CAA66169.1.
Z73127 Genomic DNA. Translation: CAA97470.1.
BK006945 Genomic DNA. Translation: DAA09298.1.
PIRiS64770.
RefSeqiNP_013078.1. NM_001181842.1.

Genome annotation databases

EnsemblFungiiYLL022C; YLL022C; YLL022C.
GeneIDi850638.
KEGGisce:YLL022C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97560 Genomic DNA. Translation: CAA66169.1.
Z73127 Genomic DNA. Translation: CAA97470.1.
BK006945 Genomic DNA. Translation: DAA09298.1.
PIRiS64770.
RefSeqiNP_013078.1. NM_001181842.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NQ0X-ray2.10A1-385[»]
ProteinModelPortaliQ12373.
SMRiQ12373. Positions 13-79, 160-346.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31231. 38 interactions.
DIPiDIP-6442N.
IntActiQ12373. 6 interactions.
MINTiMINT-473929.

PTM databases

iPTMnetiQ12373.

Proteomic databases

MaxQBiQ12373.
PeptideAtlasiQ12373.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLL022C; YLL022C; YLL022C.
GeneIDi850638.
KEGGisce:YLL022C.

Organism-specific databases

EuPathDBiFungiDB:YLL022C.
SGDiS000003945. HIF1.

Phylogenomic databases

InParanoidiQ12373.
KOiK11372.
OrthoDBiEOG7VMPG8.

Enzyme and pathway databases

BioCyciYEAST:G3O-32126-MONOMER.

Miscellaneous databases

PROiQ12373.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR011990. TPR-like_helical_dom.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of 32kb on the left arm of yeast chromosome XII reveals six known genes, a new member of the seripauperins family and a new ABC transporter homologous to the human multidrug resistance protein."
    Purnelle B., Goffeau A.
    Yeast 13:183-188(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Hif1 is a component of yeast histone acetyltransferase B, a complex mainly localized in the nucleus."
    Poveda A., Pamblanco M., Tafrov S., Tordera V., Sternglanz R., Sendra R.
    J. Biol. Chem. 279:16033-16043(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NUCLEAR HAT-B COMPLEX, FUNCTION OF THE HAT-B COMPLEX, INTERACTION WITH HISTONE H4, SUBCELLULAR LOCATION.
  7. "The nuclear Hat1p/Hat2p complex: a molecular link between type B histone acetyltransferases and chromatin assembly."
    Ai X., Parthun M.R.
    Mol. Cell 14:195-205(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE NUCLEAR HAT-B COMPLEX, INTERACTION WITH HISTONES H3 AND H4, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHIF1_YEAST
AccessioniPrimary (citable) accession number: Q12373
Secondary accession number(s): D6VXY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4550 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.