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Protein

S-methylmethionine permease 1

Gene

MMP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity S-methylmethionine (SMM) permease, required for utilization of S-methylmethionine as a sulfur source.1 Publication

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • L-amino acid transmembrane transporter activity Source: GO_Central
  • S-methylmethionine transmembrane transporter activity Source: SGD

GO - Biological processi

  • S-methylmethionine transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32158-MONOMER.

Protein family/group databases

TCDBi2.A.3.10.16. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methylmethionine permease 1
Gene namesi
Name:MMP1
Ordered Locus Names:YLL061W
ORF Names:L0555
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL061W.
SGDiS000003984. MMP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 77CytoplasmicSequence analysisAdd BLAST77
Transmembranei78 – 96HelicalSequence analysisAdd BLAST19
Topological domaini97 – 101ExtracellularSequence analysis5
Transmembranei102 – 123HelicalSequence analysisAdd BLAST22
Topological domaini124 – 143CytoplasmicSequence analysisAdd BLAST20
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 182ExtracellularSequence analysisAdd BLAST18
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 215CytoplasmicSequence analysisAdd BLAST12
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Topological domaini237 – 254ExtracellularSequence analysisAdd BLAST18
Transmembranei255 – 274HelicalSequence analysisAdd BLAST20
Topological domaini275 – 298CytoplasmicSequence analysisAdd BLAST24
Transmembranei299 – 319HelicalSequence analysisAdd BLAST21
Topological domaini320 – 356ExtracellularSequence analysisAdd BLAST37
Transmembranei357 – 377HelicalSequence analysisAdd BLAST21
Topological domaini378 – 402CytoplasmicSequence analysisAdd BLAST25
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 428ExtracellularSequence analysis5
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21
Topological domaini450 – 473CytoplasmicSequence analysisAdd BLAST24
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Topological domaini495 – 505ExtracellularSequence analysisAdd BLAST11
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Topological domaini527 – 583CytoplasmicSequence analysisAdd BLAST57

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
  • vacuole Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541571 – 583S-methylmethionine permease 1Add BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei21PhosphothreonineCombined sources1
Modified residuei23PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12372.
PRIDEiQ12372.

PTM databases

iPTMnetiQ12372.

Interactioni

Protein-protein interaction databases

BioGridi31255. 24 interactors.
DIPiDIP-8952N.
IntActiQ12372. 2 interactors.
MINTiMINT-4494329.

Structurei

3D structure databases

ProteinModelPortaliQ12372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiQ12372.
KOiK16261.
OMAiFVLAFNR.
OrthoDBiEOG092C164R.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEFESTKLS KVQFSTSVLS TPSNEGNNLI HRFKNSFKRN DSPAIQEGLL
60 70 80 90 100
YSELSEEEKI QWDLANQPYK KVLDQRHLTM IAIGGTLGTG LFIGLGESLA
110 120 130 140 150
SGPASLLIGF LLVGASMLCV VQCGAELSCQ YPVSGSYALH ASRFIDPSVG
160 170 180 190 200
FSIGINYLLM WLISYPSELV GCSLTISYWA PSVNPAAWVA IAFVLSMLLN
210 220 230 240 250
LFGARGFAES EFYMSIFKIV ALFIFIIIGI VLIAGGGPDS TGYIGTKYWH
260 270 280 290 300
DPGSFAVPVF KNLCNTFVSA AYSFSGTEMV VLTSTEARSV SSVSRAAKGT
310 320 330 340 350
FWRIIIFYIV TVIIIGCLVP YNDPRLISGS SSEDITASPF VIALSNTGAM
360 370 380 390 400
GTRVSHFMNA VILIAVFSVC NSCVYASSRL IQGLATAGQL PKICAYMDRN
410 420 430 440 450
GRPLVGMAIC GAFGLLGFLV VSKNQGTVFT WLFALCSISF FTTWFCICFC
460 470 480 490 500
QVRFRMAMKA QGRSKDDIIY RSTLGIYGGI FGCILNVLLV IGEIYVSAAP
510 520 530 540 550
VGSPSSAANF FEYCMSIPIM IAVYIGHRIY RRDWRHWYIK RMDIDLDSGH
560 570 580
SLEDFEATKL ERDEDKKYVS SKPLYYRIYR FFC
Length:583
Mass (Da):64,218
Last modified:November 1, 1996 - v1
Checksum:iAF88AB299957C5AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73166 Genomic DNA. Translation: CAA97514.1.
Z47973 Genomic DNA. Translation: CAA87996.1.
BK006945 Genomic DNA. Translation: DAA09264.1.
PIRiS50959.
RefSeqiNP_013039.1. NM_001181881.1.

Genome annotation databases

EnsemblFungiiYLL061W; YLL061W; YLL061W.
GeneIDi850665.
KEGGisce:YLL061W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73166 Genomic DNA. Translation: CAA97514.1.
Z47973 Genomic DNA. Translation: CAA87996.1.
BK006945 Genomic DNA. Translation: DAA09264.1.
PIRiS50959.
RefSeqiNP_013039.1. NM_001181881.1.

3D structure databases

ProteinModelPortaliQ12372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31255. 24 interactors.
DIPiDIP-8952N.
IntActiQ12372. 2 interactors.
MINTiMINT-4494329.

Protein family/group databases

TCDBi2.A.3.10.16. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiQ12372.

Proteomic databases

MaxQBiQ12372.
PRIDEiQ12372.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLL061W; YLL061W; YLL061W.
GeneIDi850665.
KEGGisce:YLL061W.

Organism-specific databases

EuPathDBiFungiDB:YLL061W.
SGDiS000003984. MMP1.

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiQ12372.
KOiK16261.
OMAiFVLAFNR.
OrthoDBiEOG092C164R.

Enzyme and pathway databases

BioCyciYEAST:G3O-32158-MONOMER.

Miscellaneous databases

PROiQ12372.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMMP1_YEAST
AccessioniPrimary (citable) accession number: Q12372
Secondary accession number(s): D6VXU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.