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Protein

S-methylmethionine permease 1

Gene

MMP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity S-methylmethionine (SMM) permease, required for utilization of S-methylmethionine as a sulfur source.1 Publication

GO - Molecular functioni

  • S-methylmethionine transmembrane transporter activity Source: SGD

GO - Biological processi

  • S-methylmethionine transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32158-MONOMER.

Protein family/group databases

TCDBi2.A.3.10.16. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methylmethionine permease 1
Gene namesi
Name:MMP1
Ordered Locus Names:YLL061W
ORF Names:L0555
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL061W.
SGDiS000003984. MMP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7777CytoplasmicSequence analysisAdd
BLAST
Transmembranei78 – 9619HelicalSequence analysisAdd
BLAST
Topological domaini97 – 1015ExtracellularSequence analysis
Transmembranei102 – 12322HelicalSequence analysisAdd
BLAST
Topological domaini124 – 14320CytoplasmicSequence analysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence analysisAdd
BLAST
Topological domaini165 – 18218ExtracellularSequence analysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence analysisAdd
BLAST
Topological domaini204 – 21512CytoplasmicSequence analysisAdd
BLAST
Transmembranei216 – 23621HelicalSequence analysisAdd
BLAST
Topological domaini237 – 25418ExtracellularSequence analysisAdd
BLAST
Transmembranei255 – 27420HelicalSequence analysisAdd
BLAST
Topological domaini275 – 29824CytoplasmicSequence analysisAdd
BLAST
Transmembranei299 – 31921HelicalSequence analysisAdd
BLAST
Topological domaini320 – 35637ExtracellularSequence analysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence analysisAdd
BLAST
Topological domaini378 – 40225CytoplasmicSequence analysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence analysisAdd
BLAST
Topological domaini424 – 4285ExtracellularSequence analysis
Transmembranei429 – 44921HelicalSequence analysisAdd
BLAST
Topological domaini450 – 47324CytoplasmicSequence analysisAdd
BLAST
Transmembranei474 – 49421HelicalSequence analysisAdd
BLAST
Topological domaini495 – 50511ExtracellularSequence analysisAdd
BLAST
Transmembranei506 – 52621HelicalSequence analysisAdd
BLAST
Topological domaini527 – 58357CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 583583S-methylmethionine permease 1PRO_0000054157Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61PhosphoserineBy similarity
Modified residuei21 – 211PhosphothreonineCombined sources
Modified residuei23 – 231PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12372.

PTM databases

iPTMnetiQ12372.

Interactioni

Protein-protein interaction databases

BioGridi31255. 24 interactions.
DIPiDIP-8952N.
IntActiQ12372. 2 interactions.
MINTiMINT-4494329.

Structurei

3D structure databases

ProteinModelPortaliQ12372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiQ12372.
KOiK16261.
OMAiCAFAPIS.
OrthoDBiEOG74J9HZ.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.

Sequencei

Sequence statusi: Complete.

Q12372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEFESTKLS KVQFSTSVLS TPSNEGNNLI HRFKNSFKRN DSPAIQEGLL
60 70 80 90 100
YSELSEEEKI QWDLANQPYK KVLDQRHLTM IAIGGTLGTG LFIGLGESLA
110 120 130 140 150
SGPASLLIGF LLVGASMLCV VQCGAELSCQ YPVSGSYALH ASRFIDPSVG
160 170 180 190 200
FSIGINYLLM WLISYPSELV GCSLTISYWA PSVNPAAWVA IAFVLSMLLN
210 220 230 240 250
LFGARGFAES EFYMSIFKIV ALFIFIIIGI VLIAGGGPDS TGYIGTKYWH
260 270 280 290 300
DPGSFAVPVF KNLCNTFVSA AYSFSGTEMV VLTSTEARSV SSVSRAAKGT
310 320 330 340 350
FWRIIIFYIV TVIIIGCLVP YNDPRLISGS SSEDITASPF VIALSNTGAM
360 370 380 390 400
GTRVSHFMNA VILIAVFSVC NSCVYASSRL IQGLATAGQL PKICAYMDRN
410 420 430 440 450
GRPLVGMAIC GAFGLLGFLV VSKNQGTVFT WLFALCSISF FTTWFCICFC
460 470 480 490 500
QVRFRMAMKA QGRSKDDIIY RSTLGIYGGI FGCILNVLLV IGEIYVSAAP
510 520 530 540 550
VGSPSSAANF FEYCMSIPIM IAVYIGHRIY RRDWRHWYIK RMDIDLDSGH
560 570 580
SLEDFEATKL ERDEDKKYVS SKPLYYRIYR FFC
Length:583
Mass (Da):64,218
Last modified:November 1, 1996 - v1
Checksum:iAF88AB299957C5AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73166 Genomic DNA. Translation: CAA97514.1.
Z47973 Genomic DNA. Translation: CAA87996.1.
BK006945 Genomic DNA. Translation: DAA09264.1.
PIRiS50959.
RefSeqiNP_013039.1. NM_001181881.1.

Genome annotation databases

EnsemblFungiiYLL061W; YLL061W; YLL061W.
GeneIDi850665.
KEGGisce:YLL061W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73166 Genomic DNA. Translation: CAA97514.1.
Z47973 Genomic DNA. Translation: CAA87996.1.
BK006945 Genomic DNA. Translation: DAA09264.1.
PIRiS50959.
RefSeqiNP_013039.1. NM_001181881.1.

3D structure databases

ProteinModelPortaliQ12372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31255. 24 interactions.
DIPiDIP-8952N.
IntActiQ12372. 2 interactions.
MINTiMINT-4494329.

Protein family/group databases

TCDBi2.A.3.10.16. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiQ12372.

Proteomic databases

MaxQBiQ12372.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLL061W; YLL061W; YLL061W.
GeneIDi850665.
KEGGisce:YLL061W.

Organism-specific databases

EuPathDBiFungiDB:YLL061W.
SGDiS000003984. MMP1.

Phylogenomic databases

GeneTreeiENSGT00510000049744.
HOGENOMiHOG000261848.
InParanoidiQ12372.
KOiK16261.
OMAiCAFAPIS.
OrthoDBiEOG74J9HZ.

Enzyme and pathway databases

BioCyciYEAST:G3O-32158-MONOMER.

Miscellaneous databases

PROiQ12372.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR002293. AA/rel_permease1.
IPR004762. Amino_acid_permease_fungi.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF00324. AA_permease. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00913. 2A0310. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Transport of sulfonium compounds. Characterization of the s-adenosylmethionine and s-methylmethionine permeases from the yeast Saccharomyces cerevisiae."
    Rouillon A., Surdin-Kerjan Y., Thomas D.
    J. Biol. Chem. 274:28096-28105(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-21 AND SER-23, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMMP1_YEAST
AccessioniPrimary (citable) accession number: Q12372
Secondary accession number(s): D6VXU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.