UniProtKB - Q12359 (ATO3_YEAST)
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Protein
Ammonia transport outward protein 3
Gene
ATO3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Transporter protein required for ammonia export. Induced in rho0 cells, probably to eliminate the excess ammonia that arises because of a potential defect in ammonia assimilation in those cells.1 Publication
GO - Molecular functioni
- acetate transmembrane transporter activity Source: GO_Central
- ammonium transmembrane transporter activity Source: SGD
GO - Biological processi
- ammonium transport Source: SGD
- nitrogen utilization Source: SGD
- plasma membrane acetate transport Source: GO_Central
- transmembrane transport Source: SGD
Keywordsi
Biological process | Ammonia transport, Ion transport, Transport |
Enzyme and pathway databases
BioCyci | YEAST:G3O-29932-MONOMER. |
Protein family/group databases
TCDBi | 2.A.96.1.5. the acetate uptake transporter (acetr) family. |
Names & Taxonomyi
Protein namesi | Recommended name: Ammonia transport outward protein 3 |
Gene namesi | Name:ATO3 Ordered Locus Names:YDR384C ORF Names:D9481.20, D9509.4 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YDR384C. |
SGDi | S000002792. ATO3. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 84 | ExtracellularSequence analysisAdd BLAST | 84 | |
Transmembranei | 85 – 105 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 106 – 120 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 121 – 141 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 142 – 181 | ExtracellularSequence analysisAdd BLAST | 40 | |
Transmembranei | 182 – 202 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 203 – 207 | CytoplasmicSequence analysis | 5 | |
Transmembranei | 208 – 228 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 229 – 236 | ExtracellularSequence analysis | 8 | |
Transmembranei | 237 – 257 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 258 – 275 | CytoplasmicSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000135707 | 1 – 275 | Ammonia transport outward protein 3Add BLAST | 275 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 4 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q12359. |
PRIDEi | Q12359. |
TopDownProteomicsi | Q12359. |
PTM databases
iPTMneti | Q12359. |
Expressioni
Inductioni
Expression is under the control of the ADR1, CAT8, and GCN4 transcription factors. Also induced by external ammonia and in rho0 cells.3 Publications
Interactioni
Protein-protein interaction databases
BioGridi | 32445. 22 interactors. |
DIPi | DIP-4513N. |
IntActi | Q12359. 2 interactors. |
MINTi | Q12359. |
STRINGi | 4932.YDR384C. |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00390000006887. |
HOGENOMi | HOG000224167. |
InParanoidi | Q12359. |
KOi | K07034. |
OMAi | MTVFSSF. |
OrthoDBi | EOG092C3O7T. |
Family and domain databases
InterProi | View protein in InterPro IPR000791. Grp1/Fun34/SatP. |
Pfami | View protein in Pfam PF01184. Grp1_Fun34_YaaH. 1 hit. |
PROSITEi | View protein in PROSITE PS01114. GPR1_FUN34_YAAH. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q12359-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSSASSPQD LEKGVNTLEN IETLPQQGSI AGVSQGFPNI QEIYSDRDFI
60 70 80 90 100
TLGSSTYRRR DLLNALDRGD GEEGNCAKYT PHQFANPVPL GLASFSLSCL
110 120 130 140 150
VLSLINANVR GVTDGKWALS LFMFFGGAIE LFAGLLCFVI GDTYAMTVFS
160 170 180 190 200
SFGGFWICYG YGLTDTDNLV SGYTDPTMLN NVIGFFLAGW TVFTFLMLMC
210 220 230 240 250
TLKSTWGLFL LLTFLDLTFL LLCIGTFIDN NNLKMAGGYF GILSSCCGWY
260 270
SLYCSVVSPS NSYLAFRAHT MPNAP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28373 Genomic DNA. Translation: AAB64820.1. U32274 Genomic DNA. Translation: AAB64826.1. BK006938 Genomic DNA. Translation: DAA12228.1. |
PIRi | S61179. |
RefSeqi | NP_010672.1. NM_001180692.1. |
Genome annotation databases
EnsemblFungii | YDR384C; YDR384C; YDR384C. |
GeneIDi | 851992. |
KEGGi | sce:YDR384C. |
Similar proteinsi
Entry informationi
Entry namei | ATO3_YEAST | |
Accessioni | Q12359Primary (citable) accession number: Q12359 Secondary accession number(s): D6VT18 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 28, 2018 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |