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Protein

Alpha-ketoglutarate-dependent sulfonate dioxygenase

Gene

JLP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an alpha-ketoglutarate-dependent dioxygenase active on sulfonates. Although taurine is a poor substrate, a variety of other sulfonates are utilized, with the best natural substrates being isethionate and taurocholate.1 Publication

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Pathwayi: alkanesulfonate degradation

This protein is involved in the pathway alkanesulfonate degradation, which is part of Organosulfur degradation.
View all proteins of this organism that are known to be involved in the pathway alkanesulfonate degradation and in Organosulfur degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi218Iron; catalyticBy similarity1
Metal bindingi220Iron; catalyticBy similarity1
Binding sitei2452-oxoglutarateBy similarity1
Binding sitei3522-oxoglutarateBy similarity1
Metal bindingi367Iron; catalyticBy similarity1
Binding sitei3792-oxoglutarateBy similarity1
Binding sitei3832-oxoglutarateBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • sulfonate dioxygenase activity Source: SGD
  • taurine dioxygenase activity Source: GO_Central

GO - Biological processi

  • alkanesulfonate catabolic process Source: UniProtKB-UniPathway
  • sulfur compound catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32156-MONOMER.
UniPathwayiUPA00338.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-ketoglutarate-dependent sulfonate dioxygenase (EC:1.14.11.-)
Gene namesi
Name:JLP1
Ordered Locus Names:YLL057C
ORF Names:L0572
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL057C.
SGDiS000003980. JLP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001940221 – 412Alpha-ketoglutarate-dependent sulfonate dioxygenaseAdd BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ12358.

PTM databases

iPTMnetiQ12358.

Interactioni

Protein-protein interaction databases

BioGridi31258. 22 interactors.
DIPiDIP-1933N.
IntActiQ12358. 1 interactor.
MINTiMINT-387964.

Structurei

3D structure databases

ProteinModelPortaliQ12358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TfdA dioxygenase family.Curated

Phylogenomic databases

HOGENOMiHOG000165073.
InParanoidiQ12358.
KOiK19245.
OMAiATHDFTK.
OrthoDBiEOG092C2QNA.

Family and domain databases

InterProiIPR003819. TauD/TfdA-like.
[Graphical view]
PfamiPF02668. TauD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12358-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPAAAQTAI PLPSTDLPVK IITNGLKNLN YTSKQGYGNF DTHFYDGQDE
60 70 80 90 100
VSPSGLLKIR KSYREKSKYP DYLPTWDPTE KYGPLEFHEY HDPALRADGN
110 120 130 140 150
FSNLFAKENV GQLKVKKITP KLGLEINGIQ LTDLSDAAKD ELALLVAQKG
160 170 180 190 200
VVVFRNQNFA DEGPDYVTEY GRHFGKLHIH QTSGHPQNNP ELHITFRRPD
210 220 230 240 250
AEEFARVFDD STSSGGWHTD VSYELQPPSY TFFSVVEGPD GGGDTLFADT
260 270 280 290 300
IEAFDRLSKP LQDFLSTLHV IHSSKEQAEN SQRQGGIKRR APVTHIHPLV
310 320 330 340 350
RVHPVLKKKC LYVNRAFSRK IVELKRQESE SLLNFLYNLV ESSHDLQLRA
360 370 380 390 400
KWEPHSVVIW DNRRVQHSAV IDWEEPIHRH AFRITPQAER PVEDLKFLND
410
ENYYPSSLTL DI
Length:412
Mass (Da):46,983
Last modified:November 1, 1996 - v1
Checksum:iF1BB8588B56CEEBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47973 Genomic DNA. Translation: CAA88000.1.
Z73162 Genomic DNA. Translation: CAA97510.1.
AY692737 Genomic DNA. Translation: AAT92756.1.
BK006945 Genomic DNA. Translation: DAA09267.1.
PIRiS50963.
RefSeqiNP_013043.1. NM_001181877.1.

Genome annotation databases

EnsemblFungiiYLL057C; YLL057C; YLL057C.
GeneIDi850669.
KEGGisce:YLL057C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47973 Genomic DNA. Translation: CAA88000.1.
Z73162 Genomic DNA. Translation: CAA97510.1.
AY692737 Genomic DNA. Translation: AAT92756.1.
BK006945 Genomic DNA. Translation: DAA09267.1.
PIRiS50963.
RefSeqiNP_013043.1. NM_001181877.1.

3D structure databases

ProteinModelPortaliQ12358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31258. 22 interactors.
DIPiDIP-1933N.
IntActiQ12358. 1 interactor.
MINTiMINT-387964.

PTM databases

iPTMnetiQ12358.

Proteomic databases

PRIDEiQ12358.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLL057C; YLL057C; YLL057C.
GeneIDi850669.
KEGGisce:YLL057C.

Organism-specific databases

EuPathDBiFungiDB:YLL057C.
SGDiS000003980. JLP1.

Phylogenomic databases

HOGENOMiHOG000165073.
InParanoidiQ12358.
KOiK19245.
OMAiATHDFTK.
OrthoDBiEOG092C2QNA.

Enzyme and pathway databases

UniPathwayiUPA00338.
BioCyciYEAST:G3O-32156-MONOMER.

Miscellaneous databases

PROiQ12358.

Family and domain databases

InterProiIPR003819. TauD/TfdA-like.
[Graphical view]
PfamiPF02668. TauD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiJLP1_YEAST
AccessioniPrimary (citable) accession number: Q12358
Secondary accession number(s): D6VXV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.