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Protein

Cell wall mannoprotein PST1

Gene

PST1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a partially redundant function to ECM33 in cell wall integrity. May be involved in a repair mechanism activated in response to cell wall damage.2 Publications

Miscellaneous

Present with 11700 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • fungal-type cell wall organization Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-29664-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cell wall mannoprotein PST1
Alternative name(s):
Haze protective factor 2
Protoplast secreted protein 1
Gene namesi
Name:PST1
Synonyms:HPF2
Ordered Locus Names:YDR055W
ORF Names:D4214, YD9609.09
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR055W
SGDiS000002462 PST1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell wall, Membrane, Secreted

Pathology & Biotechi

Biotechnological usei

Mannoprotein called haze protective factor from wine that is able to prevent visible wine protein haze formation. This mannoprotein showed haze-protective activity against wine proteins and BSA when either was heated in white wine.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003319320 – 419Cell wall mannoprotein PST1Add BLAST400
PropeptideiPRO_0000033194420 – 444Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi228N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi235N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi242N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi263N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi329N-linked (GlcNAc...) asparagine1 Publication1
Lipidationi419GPI-anchor amidated asparagineSequence analysis1

Post-translational modificationi

Extensively N- and O-mannosylated.

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ12355
PaxDbiQ12355
PRIDEiQ12355

2D gel databases

COMPLUYEAST-2DPAGEQ12355

PTM databases

iPTMnetiQ12355

Expressioni

Inductioni

Positively regulated by cell integrity signaling through MPK1 in response to cell wall perturbation. Induction is dependent on transcription factor RLM1.3 Publications

Interactioni

Protein-protein interaction databases

BioGridi32108, 64 interactors
DIPiDIP-7811N
IntActiQ12355, 1 interactor
MINTiQ12355
STRINGi4932.YDR055W

Structurei

3D structure databases

ProteinModelPortaliQ12355
SMRiQ12355
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 26Poly-Ser5
Compositional biasi356 – 416Ser-richAdd BLAST61

Sequence similaritiesi

Belongs to the SPS2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00530000065410
HOGENOMiHOG000093252
InParanoidiQ12355
OMAiCTISSHA
OrthoDBiEOG092C3DSS

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q12355-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLHSLIAST ALLITSALAA TSSSSSIPSS CTISSHATAT AQSDLDKYSR
60 70 80 90 100
CDTLVGNLTI GGGLKTGALA NVKEINGSLT IFNATNLTSF AADSLESITD
110 120 130 140 150
SLNLQSLTIL TSASFGSLQS VDSIKLITLP AISSFTSNIK SANNIYISDT
160 170 180 190 200
SLQSVDGFSA LKKVNVFNVN NNKKLTSIKS PVETVSDSLQ FSFNGNQTKI
210 220 230 240 250
TFDDLVWANN ISLTDVHSVS FANLQKINSS LGFINNSISS LNFTKLNTIG
260 270 280 290 300
QTFSIVSNDY LKNLSFSNLS TIGGALVVAN NTGLQKIGGL DNLTTIGGTL
310 320 330 340 350
EVVGNFTSLN LDSLKSVKGG ADVESKSSNF SCNALKALQK KGGIKGESFV
360 370 380 390 400
CKNGASSTSV KLSSTSKSQS SQTTAKVSKS SSKAEEKKFT SGDIKAAASA
410 420 430 440
SSVSSSGASS SSSKSSKGNA AIMAPIGQTT PLVGLLTAII MSIM
Length:444
Mass (Da):45,777
Last modified:November 1, 1996 - v1
Checksum:i230F60CACA5921A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84162 Genomic DNA Translation: CAA58971.1
Z74351 Genomic DNA Translation: CAA98873.1
Z49209 Genomic DNA Translation: CAA89084.1
BK006938 Genomic DNA Translation: DAA11901.1
PIRiS54039
RefSeqiNP_010340.1, NM_001180363.1

Genome annotation databases

EnsemblFungiiYDR055W; YDR055W; YDR055W
GeneIDi851625
KEGGisce:YDR055W

Similar proteinsi

Entry informationi

Entry nameiPST1_YEAST
AccessioniPrimary (citable) accession number: Q12355
Secondary accession number(s): D6VS41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health