Reviewed, UniProtKB/Swiss-Prot Q12339 (UTP23_YEAST)

Names and origin

Protein names

Recommended name:
    rRNA-processing protein UTP23
Alternative name(s):
    U3 small nucleolar RNA-associated protein 23
      Short name=U3 snoRNA-associated protein 23
    U three protein 23

Gene names

Name:	UTP23
Ordered Locus Names:	YOR004W

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in rRNA-processing and ribosome biogenesis. Ref.3
Subcellular location	Mitochondrion. Nucleus › nucleolus Ref.4 Ref.5.
Miscellaneous	Present with 6960 molecules/cell in log phase SD medium. Ref.6
Sequence similarities	Belongs to the UTP23/FCF1 family. UTP23 subfamily.

Ontologies

Keywords
Biological process	Ribosome biogenesis rRNA processing
Cellular component	Mitochondrion Nucleus
Ligand	RNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Inferred from mutant phenotype. Source: SGD endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Inferred from mutant phenotype. Source: SGD endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Inferred from mutant phenotype. Source: SGD
Cellular component	mitochondrion Ref.5 Inferred from direct assay. Source: SGD nucleolus Ref.4 Inferred from direct assay. Source: SGD small-subunit processome Inferred from direct assay. Source: SGD
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GAR1	P28007	1	EBI-30231,EBI-7321
SNU114	P36048	1	EBI-30231,EBI-243
SOF1	P33750	1	EBI-30231,EBI-17651

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	rRNA-processing protein UTP23		PRO_0000245250
Regions
	Compositional bias	188 – 239	52	Lys-rich
Amino acid modifications
	Modified residue	182	1	Phosphoserine Ref.7
	Modified residue	215	1	Phosphoserine Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Q12339-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 27D00C72F6B492F6	FASTA	254	28,801
	10 20 30 40 50 60 MRQKRAKSYR KQLLVYSHTF KFREPYQVLV DNQLVLECNN SNFNLPSGLK RTLQADVKVM 70 80 90 100 110 120 ITQCCIQALY ETRNDGAINL AKQFERRRCN HSFKDPKSPA ECIESVVNIS GANKHRYVVA 130 140 150 160 170 180 SQDIDLRRKL RTVPGVPLIH LTRSVMVMEP LSTASAKASK ITEEQKLYKG LNDPNIEKLQ 190 200 210 220 230 240 ESGDGSGKES ITKKRKLGPK APNPLSVKKK KKVNSPSDEV KDKEDTSKEK KKRRRRKHKS 250 NTNVPVSNGT TAAQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of a 30 kb fragment on the left arm of chromosome XV from Saccharomyces cerevisiae reveals 15 open reading frames, five of which correspond to previously identified genes." Sterky F., Holmberg A., Pettersson B., Uhlen M. Yeast 12:1091-1095(1996) [PubMed: 8896276] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed: 9169874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	"Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters." Wu L.F., Hughes T.R., Davierwala A.P., Robinson M.D., Stoughton R., Altschuler S.J. Nat. Genet. 31:255-265(2002) [PubMed: 12089522] [Abstract] Cited for: FUNCTION.
[4]	"Assigning function to yeast proteins by integration of technologies." Hazbun T.R., Malmstroem L., Anderson S., Graczyk B.J., Fox B., Riffle M., Sundin B.A., Aranda J.D., McDonald W.H., Chiu C.-H., Snydsman B.E., Bradley P., Muller E.G.D., Fields S., Baker D., Yates J.R. III, Davis T.N. Mol. Cell 12:1353-1365(2003) [PubMed: 14690591] [Abstract] Cited for: SUBCELLULAR LOCATION.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND SER-215, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U43491 Genomic DNA. Translation: AAC49483.1. Z74912 Genomic DNA. Translation: CAA99192.1.
PIR	S61987.
RefSeq	NP_014646.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4352N.
IntAct	Q12339. 22 interactions.
STRING	Q12339.
Proteomic databases
PeptideAtlas	Q12339.
Genome annotation databases
Ensembl	YOR004W; YOR004W; YOR004W; Saccharomyces cerevisiae. [Genome view]
GeneID	854165.
KEGG	sce:YOR004W.
NMPDR	fig|4932.3.peg.5741.
Organism-specific databases
CYGD	YOR004w.
SGD	S000005530. UTP23.
Phylogenomic databases
HOGENOM	HBG562115.
OMA	PGIPLMF.
OrthoDB	EOG9QZ93J.
Gene expression databases
ArrayExpress	Q12339.
Genevestigator	Q12339.
GermOnline	YOR004W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR006984. DUF652. [Graphical view]
PANTHER	PTHR12416. DUF652. 1 hit.
Pfam	PF04900. Fcf1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	975947.

Entry information

Entry name

UTP23_YEAST

Accession

Primary (citable) accession number: Q12339

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	November 1, 1996
Last modified:	December 15, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)