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Protein

Ribonuclease H2 subunit C

Gene

RNH203

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • DNA replication, removal of RNA primer Source: SGD
  • RNA catabolic process Source: SGD
  • RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC

Enzyme and pathway databases

BioCyciYEAST:G3O-32288-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease H2 subunit C
Short name:
RNase H2 subunit C
Short name:
Rnh2C
Alternative name(s):
RNase H(203)
Ribonuclease HI subunit C
Gene namesi
Name:RNH203
Ordered Locus Names:YLR154C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR154C
SGDiS000004144 RNH203

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002483871 – 110Ribonuclease H2 subunit CAdd BLAST110

Proteomic databases

MaxQBiQ12338
PaxDbiQ12338
PRIDEiQ12338

Interactioni

Subunit structurei

The RNase 2 complex is a heterotrimer composed of the catalytic subunit RNH201 and of the non-catalytic subunits RNH202 and RNH203.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31423101 interactors.
DIPiDIP-1839N
IntActiQ12338 10 interactors.
MINTiQ12338
STRINGi4932.YLR154C

Structurei

3D structure databases

ProteinModelPortaliQ12338
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ12338
OrthoDBiEOG092C5QJO

Family and domain databases

CDDicd09271 RNase_H2-C, 1 hit
InterProiView protein in InterPro
IPR013924 RNase_H2_suC

Sequencei

Sequence statusi: Complete.

Q12338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKDAVNLDA YTVSFMPFYT EYQGPTEEFK DYKFEDTIYF RGKELKREKS
60 70 80 90 100
ATPSSSDNTT SNTFSNGAIL SGNTITGKIV SVNNYEREGT DRNELARLQE
110
LISLIDVINQ
Length:110
Mass (Da):12,482
Last modified:November 1, 1996 - v1
Checksum:i87A110F6A1754426
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64F → L in AAS56535 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79456 Genomic DNA Translation: AAB35144.1
Z73326 Genomic DNA Translation: CAA97726.1
U53879 Genomic DNA Translation: AAB82388.1
AY558209 Genomic DNA Translation: AAS56535.1
BK006945 Genomic DNA Translation: DAA09465.1
PIRiS65003
RefSeqiNP_013255.1, NM_001182041.1

Genome annotation databases

EnsemblFungiiYLR154C; YLR154C; YLR154C
GeneIDi850847
KEGGisce:YLR154C

Similar proteinsi

Entry informationi

Entry nameiRNH2C_YEAST
AccessioniPrimary (citable) accession number: Q12338
Secondary accession number(s): D6VYE9, Q6Q5B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome