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Protein

Ribonuclease H2 subunit C

Gene

RNH203

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.

GO - Biological processi

  • DNA replication, removal of RNA primer Source: SGD
  • RNA catabolic process Source: SGD
  • RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32288-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease H2 subunit C
Short name:
RNase H2 subunit C
Short name:
Rnh2C
Alternative name(s):
RNase H(203)
Ribonuclease HI subunit C
Gene namesi
Name:RNH203
Ordered Locus Names:YLR154C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR154C.
SGDiS000004144. RNH203.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • ribonuclease H2 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002483871 – 110Ribonuclease H2 subunit CAdd BLAST110

Proteomic databases

MaxQBiQ12338.
PRIDEiQ12338.

Interactioni

Subunit structurei

The RNase 2 complex is a heterotrimer composed of the catalytic subunit RNH201 and of the non-catalytic subunits RNH202 and RNH203.

Binary interactionsi

WithEntry#Exp.IntActNotes
RNH201P539422EBI-33805,EBI-15663
RNH202Q056352EBI-33805,EBI-33940

Protein-protein interaction databases

BioGridi31423. 33 interactors.
DIPiDIP-1839N.
IntActiQ12338. 2 interactors.
MINTiMINT-399196.

Structurei

3D structure databases

ProteinModelPortaliQ12338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ12338.
OrthoDBiEOG092C5QJO.

Family and domain databases

CDDicd09271. RNase_H2-C. 1 hit.
InterProiIPR013924. RNase_H2_suC.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKDAVNLDA YTVSFMPFYT EYQGPTEEFK DYKFEDTIYF RGKELKREKS
60 70 80 90 100
ATPSSSDNTT SNTFSNGAIL SGNTITGKIV SVNNYEREGT DRNELARLQE
110
LISLIDVINQ
Length:110
Mass (Da):12,482
Last modified:November 1, 1996 - v1
Checksum:i87A110F6A1754426
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64F → L in AAS56535 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79456 Genomic DNA. Translation: AAB35144.1.
Z73326 Genomic DNA. Translation: CAA97726.1.
U53879 Genomic DNA. Translation: AAB82388.1.
AY558209 Genomic DNA. Translation: AAS56535.1.
BK006945 Genomic DNA. Translation: DAA09465.1.
PIRiS65003.
RefSeqiNP_013255.1. NM_001182041.1.

Genome annotation databases

EnsemblFungiiYLR154C; YLR154C; YLR154C.
GeneIDi850847.
KEGGisce:YLR154C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79456 Genomic DNA. Translation: AAB35144.1.
Z73326 Genomic DNA. Translation: CAA97726.1.
U53879 Genomic DNA. Translation: AAB82388.1.
AY558209 Genomic DNA. Translation: AAS56535.1.
BK006945 Genomic DNA. Translation: DAA09465.1.
PIRiS65003.
RefSeqiNP_013255.1. NM_001182041.1.

3D structure databases

ProteinModelPortaliQ12338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31423. 33 interactors.
DIPiDIP-1839N.
IntActiQ12338. 2 interactors.
MINTiMINT-399196.

Proteomic databases

MaxQBiQ12338.
PRIDEiQ12338.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR154C; YLR154C; YLR154C.
GeneIDi850847.
KEGGisce:YLR154C.

Organism-specific databases

EuPathDBiFungiDB:YLR154C.
SGDiS000004144. RNH203.

Phylogenomic databases

InParanoidiQ12338.
OrthoDBiEOG092C5QJO.

Enzyme and pathway databases

BioCyciYEAST:G3O-32288-MONOMER.

Miscellaneous databases

PROiQ12338.

Family and domain databases

CDDicd09271. RNase_H2-C. 1 hit.
InterProiIPR013924. RNase_H2_suC.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRNH2C_YEAST
AccessioniPrimary (citable) accession number: Q12338
Secondary accession number(s): D6VYE9, Q6Q5B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.