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Q12338

- RNH2C_YEAST

UniProt

Q12338 - RNH2C_YEAST

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Protein

Ribonuclease H2 subunit C

Gene
RNH203, YLR154C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. DNA replication, removal of RNA primer Source: SGD
  2. RNA catabolic process Source: SGD
  3. RNA phosphodiester bond hydrolysis, endonucleolytic Source: GOC
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32288-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease H2 subunit C
Short name:
RNase H2 subunit C
Short name:
Rnh2C
Alternative name(s):
RNase H(203)
Ribonuclease HI subunit C
Gene namesi
Name:RNH203
Ordered Locus Names:YLR154C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR154c.
SGDiS000004144. RNH203.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. ribonuclease H2 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 110110Ribonuclease H2 subunit CPRO_0000248387Add
BLAST

Proteomic databases

MaxQBiQ12338.
PaxDbiQ12338.

Expressioni

Gene expression databases

GenevestigatoriQ12338.

Interactioni

Subunit structurei

The RNase 2 complex is a heterotrimer composed of the catalytic subunit RNH201 and of the non-catalytic subunits RNH202 and RNH203.

Binary interactionsi

WithEntry#Exp.IntActNotes
RNH201P539422EBI-33805,EBI-15663
RNH202Q056352EBI-33805,EBI-33940

Protein-protein interaction databases

BioGridi31423. 32 interactions.
DIPiDIP-1839N.
IntActiQ12338. 2 interactions.
MINTiMINT-399196.

Structurei

3D structure databases

ProteinModelPortaliQ12338.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OMAiXALESAP.
OrthoDBiEOG754J2P.

Sequencei

Sequence statusi: Complete.

Q12338-1 [UniParc]FASTAAdd to Basket

« Hide

MTKDAVNLDA YTVSFMPFYT EYQGPTEEFK DYKFEDTIYF RGKELKREKS    50
ATPSSSDNTT SNTFSNGAIL SGNTITGKIV SVNNYEREGT DRNELARLQE 100
LISLIDVINQ 110
Length:110
Mass (Da):12,482
Last modified:November 1, 1996 - v1
Checksum:i87A110F6A1754426
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641F → L in AAS56535. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S79456 Genomic DNA. Translation: AAB35144.1.
Z73326 Genomic DNA. Translation: CAA97726.1.
U53879 Genomic DNA. Translation: AAB82388.1.
AY558209 Genomic DNA. Translation: AAS56535.1.
BK006945 Genomic DNA. Translation: DAA09465.1.
PIRiS65003.
RefSeqiNP_013255.1. NM_001182041.1.

Genome annotation databases

EnsemblFungiiYLR154C; YLR154C; YLR154C.
GeneIDi850847.
KEGGisce:YLR154C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S79456 Genomic DNA. Translation: AAB35144.1 .
Z73326 Genomic DNA. Translation: CAA97726.1 .
U53879 Genomic DNA. Translation: AAB82388.1 .
AY558209 Genomic DNA. Translation: AAS56535.1 .
BK006945 Genomic DNA. Translation: DAA09465.1 .
PIRi S65003.
RefSeqi NP_013255.1. NM_001182041.1.

3D structure databases

ProteinModelPortali Q12338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31423. 32 interactions.
DIPi DIP-1839N.
IntActi Q12338. 2 interactions.
MINTi MINT-399196.

Proteomic databases

MaxQBi Q12338.
PaxDbi Q12338.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR154C ; YLR154C ; YLR154C .
GeneIDi 850847.
KEGGi sce:YLR154C.

Organism-specific databases

CYGDi YLR154c.
SGDi S000004144. RNH203.

Phylogenomic databases

OMAi XALESAP.
OrthoDBi EOG754J2P.

Enzyme and pathway databases

BioCyci YEAST:G3O-32288-MONOMER.

Miscellaneous databases

NextBioi 967141.

Gene expression databases

Genevestigatori Q12338.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "ACS2, a Saccharomyces cerevisiae gene encoding acetyl-coenzyme A synthetase, essential for growth on glucose."
    van den Berg M.A., de Steensma H.Y.
    Eur. J. Biochem. 231:704-713(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "RNase H2 of Saccharomyces cerevisiae is a complex of three proteins."
    Jeong H.-S., Backlund P.S., Chen H.-C., Karavanov A.A., Crouch R.J.
    Nucleic Acids Res. 32:407-414(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF N-TERMINUS, IDENTIFICATION BY MASS SPECTROMETRY, INTERACTION WITH RNH201 AND RNH202.
  8. Erratum
    Jeong H.-S., Backlund P.S., Chen H.-C., Karavanov A.A., Crouch R.J.
    Nucleic Acids Res. 32:1616-1616(2004)

Entry informationi

Entry nameiRNH2C_YEAST
AccessioniPrimary (citable) accession number: Q12338
Secondary accession number(s): D6VYE9, Q6Q5B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3

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