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Protein

Protein SCM3

Gene

SCM3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • CENP-A containing nucleosome binding Source: SGD
  • histone binding Source: InterPro
  • protein heterodimerization activity Source: InterPro

GO - Biological processi

  • chromosome segregation Source: SGD
  • G2/M transition of mitotic cell cycle Source: SGD
  • kinetochore assembly Source: SGD
  • negative regulation of ubiquitin-dependent protein catabolic process Source: SGD
  • protein localization to chromosome, centromeric region Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-29538-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SCM3
Alternative name(s):
Suppressor of chromosome missegregation protein 3
Gene namesi
Name:SCM3
Ordered Locus Names:YDL139C
ORF Names:D2155
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL139C
SGDiS000002298 SCM3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002522981 – 223Protein SCM3Add BLAST223

Proteomic databases

MaxQBiQ12334
PaxDbiQ12334
PRIDEiQ12334

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CSE4P360125EBI-31788,EBI-5182

GO - Molecular functioni

Protein-protein interaction databases

BioGridi31922, 147 interactors
DIPiDIP-5045N
IntActiQ12334, 9 interactors
MINTiQ12334
STRINGi4932.YDL139C

Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi94 – 114Combined sources21
Beta strandi125 – 128Combined sources4
Helixi146 – 148Combined sources3
Helixi154 – 164Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L5ANMR-A93-172[»]
ProteinModelPortaliQ12334
SMRiQ12334
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000154269
InParanoidiQ12334
OMAiHENSETR
OrthoDBiEOG092C5628

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR018465 Scm3/HJURP
PfamiView protein in Pfam
PF10384 Scm3, 1 hit

Sequencei

Sequence statusi: Complete.

Q12334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTNKKISKR RSLKNLHGAL KGLLKESGKK SESKIRKHSD CNPVHRVYPP
60 70 80 90 100
NIEKRKTKKD DGISRPIAER NGHVYIMSKE NHIIPKLTDD EVMERHKLAD
110 120 130 140 150
ENMRKVWSNI ISKYESIEEQ GDLVDLKTGE IVEDNGHIKT LTANNSTKDK
160 170 180 190 200
RTKYTSVLRD IIDISDEEDG DKNDEYTLWA NDSEASDSEV DADNDTEEEK
210 220
DEKLIDADFK KYEAKLSKRI LRD
Length:223
Mass (Da):25,754
Last modified:October 3, 2006 - v2
Checksum:iD7668117BCC7FF12
GO

Sequence cautioni

The sequence AAS56490 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA65620 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA98712 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96876 Genomic DNA Translation: CAA65620.1 Different initiation.
Z74187 Genomic DNA Translation: CAA98712.1 Different initiation.
AY558164 Genomic DNA Translation: AAS56490.1 Different initiation.
BK006938 Genomic DNA Translation: DAA11719.1
PIRiS67685
RefSeqiNP_010142.2, NM_001180199.1

Genome annotation databases

EnsemblFungiiYDL139C; YDL139C; YDL139C
GeneIDi851416
KEGGisce:YDL139C

Similar proteinsi

Entry informationi

Entry nameiSCM3_YEAST
AccessioniPrimary (citable) accession number: Q12334
Secondary accession number(s): D6VRK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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