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Protein

Protein SCM3

Gene

SCM3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • CENP-A containing nucleosome binding Source: SGD

GO - Biological processi

  • chromosome segregation Source: SGD
  • G2/M transition of mitotic cell cycle Source: SGD
  • kinetochore assembly Source: SGD
  • negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: SGD
  • protein localization to chromosome, centromeric region Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29538-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SCM3
Alternative name(s):
Suppressor of chromosome missegregation protein 3
Gene namesi
Name:SCM3
Ordered Locus Names:YDL139C
ORF Names:D2155
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDL139C.
SGDiS000002298. SCM3.

Subcellular locationi

GO - Cellular componenti

  • condensed nuclear chromosome, centromeric region Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Protein SCM3PRO_0000252298Add
BLAST

Proteomic databases

MaxQBiQ12334.

Interactioni

GO - Molecular functioni

  • CENP-A containing nucleosome binding Source: SGD

Protein-protein interaction databases

BioGridi31922. 34 interactions.
DIPiDIP-5045N.
IntActiQ12334. 9 interactions.
MINTiMINT-543391.

Structurei

Secondary structure

1
223
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi94 – 11421Combined sources
Beta strandi125 – 1284Combined sources
Helixi146 – 1483Combined sources
Helixi154 – 16411Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L5ANMR-A93-172[»]
ProteinModelPortaliQ12334.
SMRiQ12334. Positions 93-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000154269.
InParanoidiQ12334.
OMAiHENSETR.
OrthoDBiEOG092C5628.

Family and domain databases

InterProiIPR018465. Scm3/HJURP.
[Graphical view]
PfamiPF10384. Scm3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q12334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTNKKISKR RSLKNLHGAL KGLLKESGKK SESKIRKHSD CNPVHRVYPP
60 70 80 90 100
NIEKRKTKKD DGISRPIAER NGHVYIMSKE NHIIPKLTDD EVMERHKLAD
110 120 130 140 150
ENMRKVWSNI ISKYESIEEQ GDLVDLKTGE IVEDNGHIKT LTANNSTKDK
160 170 180 190 200
RTKYTSVLRD IIDISDEEDG DKNDEYTLWA NDSEASDSEV DADNDTEEEK
210 220
DEKLIDADFK KYEAKLSKRI LRD
Length:223
Mass (Da):25,754
Last modified:October 3, 2006 - v2
Checksum:iD7668117BCC7FF12
GO

Sequence cautioni

The sequence AAS56490 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA65620 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA98712 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96876 Genomic DNA. Translation: CAA65620.1. Different initiation.
Z74187 Genomic DNA. Translation: CAA98712.1. Different initiation.
AY558164 Genomic DNA. Translation: AAS56490.1. Different initiation.
BK006938 Genomic DNA. Translation: DAA11719.1.
PIRiS67685.
RefSeqiNP_010142.2. NM_001180199.1.

Genome annotation databases

EnsemblFungiiYDL139C; YDL139C; YDL139C.
GeneIDi851416.
KEGGisce:YDL139C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96876 Genomic DNA. Translation: CAA65620.1. Different initiation.
Z74187 Genomic DNA. Translation: CAA98712.1. Different initiation.
AY558164 Genomic DNA. Translation: AAS56490.1. Different initiation.
BK006938 Genomic DNA. Translation: DAA11719.1.
PIRiS67685.
RefSeqiNP_010142.2. NM_001180199.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2L5ANMR-A93-172[»]
ProteinModelPortaliQ12334.
SMRiQ12334. Positions 93-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31922. 34 interactions.
DIPiDIP-5045N.
IntActiQ12334. 9 interactions.
MINTiMINT-543391.

Proteomic databases

MaxQBiQ12334.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL139C; YDL139C; YDL139C.
GeneIDi851416.
KEGGisce:YDL139C.

Organism-specific databases

EuPathDBiFungiDB:YDL139C.
SGDiS000002298. SCM3.

Phylogenomic databases

HOGENOMiHOG000154269.
InParanoidiQ12334.
OMAiHENSETR.
OrthoDBiEOG092C5628.

Enzyme and pathway databases

BioCyciYEAST:G3O-29538-MONOMER.

Miscellaneous databases

PROiQ12334.

Family and domain databases

InterProiIPR018465. Scm3/HJURP.
[Graphical view]
PfamiPF10384. Scm3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCM3_YEAST
AccessioniPrimary (citable) accession number: Q12334
Secondary accession number(s): D6VRK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.