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Protein

Heat shock protein 42

Gene

HSP42

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 1470 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • unfolded protein binding Source: SGD

GO - Biological processi

  • cytoskeleton organization Source: SGD

Keywordsi

Biological processStress response

Enzyme and pathway databases

BioCyciYEAST:G3O-29760-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 42
Alternative name(s):
42 kDa heat shock protein
Gene namesi
Name:HSP42
Ordered Locus Names:YDR171W
ORF Names:YD9395.04
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR171W
SGDiS000002578 HSP42

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001260051 – 375Heat shock protein 42Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei182PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei223PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ12329
PaxDbiQ12329
PRIDEiQ12329

PTM databases

iPTMnetiQ12329

Expressioni

Inductioni

By stress such as heat shock or increased salt concentration. Up-regulated by all stress conditions tested. Also expressed in unstressed cells.

Interactioni

Subunit structurei

Forms oligomeric complexes. Interacts with itself.

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC14Q006842EBI-8571,EBI-4192

GO - Molecular functioni

  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi32224, 102 interactors
DIPiDIP-2515N
IntActiQ12329, 105 interactors
MINTiQ12329
STRINGi4932.YDR171W

Structurei

3D structure databases

ProteinModelPortaliQ12329
SMRiQ12329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini237 – 356sHSPPROSITE-ProRule annotationAdd BLAST120

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000065948
InParanoidiQ12329
KOiK13993
OMAiELKYGAF
OrthoDBiEOG092C3XL8

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR008978 HSP20-like_chaperone
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

Q12329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFYQPSLSL YDVLNALSNQ TGQRGQQGYP RQPQRPQRYH PHYGQVHVGG
60 70 80 90 100
HHPRHHPLYS RYNGVPNTYY YQFPGQAYYY SPEYGYDDED GEEEDQDEDM
110 120 130 140 150
VGDSGTTRQE DGGEDSNSRR YPSYYHCNTA RNNRTNQQAN SLNDLLTALI
160 170 180 190 200
GVPPYEGTEP EIEANTEQEG EKGEEKDKKD KSEAPKEEAG ETNKEKPLNQ
210 220 230 240 250
LEESSRPPLA KKSSSFAHLQ APSPIPDPLQ VSKPETRMDL PFSPEVNVYD
260 270 280 290 300
TEDTYVVVLA LPGANSRAFH IDYHPSSHEM LIKGKIEDRV GIDEKFLKIT
310 320 330 340 350
ELKYGAFERT VKFPVLPRIK DEEIKATYNN GLLQIKVPKI VNDTEKPKPK
360 370
KRIAIEEIPD EELEFEENPN PTVEN
Length:375
Mass (Da):42,817
Last modified:November 1, 1997 - v1
Checksum:iDF353A76493E3CE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U41401 Genomic DNA Translation: AAC49256.1
Z46727 Genomic DNA Translation: CAA86676.1
AY558574 Genomic DNA Translation: AAS56900.1
BK006938 Genomic DNA Translation: DAA12013.1
PIRiS49767
RefSeqiNP_010456.1, NM_001180478.1

Genome annotation databases

EnsemblFungiiYDR171W; YDR171W; YDR171W
GeneIDi851751
KEGGisce:YDR171W

Similar proteinsi

Entry informationi

Entry nameiHSP42_YEAST
AccessioniPrimary (citable) accession number: Q12329
Secondary accession number(s): D6VSF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  2. Protein nomenclature information
    List of publications dealing with protein nomenclature and links to specialized websites

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