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Protein

Phosphoglycerate mutase 3

Gene

GPM3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be non-functional.

Miscellaneous

Present with 3730 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 1 (TDH1), Glyceraldehyde-3-phosphate dehydrogenase 2 (TDH2), Glyceraldehyde-3-phosphate dehydrogenase 3 (TDH3)
  2. Phosphoglycerate kinase (PGK1)
  3. Phosphoglycerate mutase 2 (GPM2), Phosphoglycerate mutase 3 (GPM3), Phosphoglycerate mutase 1 (GPM1)
  4. Enolase 2 (ENO2), Enolase-related protein 2 (ERR2), Enolase-related protein 3 (ERR3), Enolase-related protein 1 (ERR1), Enolase 1 (ENO1)
  5. Pyruvate kinase 2 (PYK2), Pyruvate kinase 1 (CDC19)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei14Tele-phosphohistidine intermediateBy similarity1
Binding sitei70SubstrateBy similarity1
Active sitei120Proton donor/acceptorBy similarity1
Binding sitei131SubstrateBy similarity1
Sitei235Transition state stabilizerBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGlycolysis

Enzyme and pathway databases

BioCyciYEAST:G3O-33467-MONOMER
UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate mutase 3 (EC:5.4.2.11)
Short name:
PGAM 3
Alternative name(s):
BPG-dependent PGAM 3
MPGM 3
Phosphoglyceromutase 3
Gene namesi
Name:GPM3
Ordered Locus Names:YOL056W
ORF Names:O1236
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOL056W
SGDiS000005417 GPM3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001798411 – 303Phosphoglycerate mutase 3Add BLAST303

Proteomic databases

MaxQBiQ12326
PaxDbiQ12326
PRIDEiQ12326

Interactioni

Protein-protein interaction databases

BioGridi34345, 92 interactors
DIPiDIP-4234N
IntActiQ12326, 5 interactors
STRINGi4932.YOL056W

Structurei

3D structure databases

ProteinModelPortaliQ12326
SMRiQ12326
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 20Substrate bindingBy similarity8
Regioni26 – 27Substrate bindingBy similarity2
Regioni120 – 123Substrate bindingBy similarity4
Regioni147 – 148Substrate bindingBy similarity2
Regioni236 – 237Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000075884
HOGENOMiHOG000221682
InParanoidiQ12326
KOiK01834
OMAiNRYYYTI
OrthoDBiEOG092C3A2P

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 3 hits
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q12326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVTDTFKLF ILRHGQSELN SENIFCGWID AQLTEKGKSQ ARHSAKLIKQ
60 70 80 90 100
FCDSNNISLP QIGYTSRLIR TQQTMDVILE ELGLKHTNYV ITTNTNIKEE
110 120 130 140 150
LQDTRFEGSM PVLQTWRLNE RHYGAWQGQR KPDILKEYGK EKYMYIRRDY
160 170 180 190 200
NGKPPKVNLN LEMVQEENDQ GSSTGYDFKE PNRHLKYGPE EKANERLPES
210 220 230 240 250
ESLCEVVVRL KPFLNNVVLS TANKISQESC VIVGHGSSVR SLLKVLEGIS
260 270 280 290 300
DEDIKDVDIP NGIPLVIELD RDNYSFVRKF YLDPESAKVN AQMVRDEGFE

KNP
Length:303
Mass (Da):34,863
Last modified:November 1, 1997 - v1
Checksum:i29C3FF3D28560914
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91067 Genomic DNA Translation: CAA62530.1
Z74798 Genomic DNA Translation: CAA99064.1
BK006948 Genomic DNA Translation: DAA10727.1
PIRiS61723
RefSeqiNP_014585.1, NM_001183311.1

Genome annotation databases

EnsemblFungiiYOL056W; YOL056W; YOL056W
GeneIDi854098
KEGGisce:YOL056W

Similar proteinsi

Entry informationi

Entry nameiPMG3_YEAST
AccessioniPrimary (citable) accession number: Q12326
Secondary accession number(s): D6W211
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

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