Q12326 (PMG3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate mutase 3
Short name=PGAM 3
EC=5.4.2.1

Alternative name(s):
BPG-dependent PGAM 3
MPGM 3
Phosphoglyceromutase 3

Gene names

Name:	GPM3
Ordered Locus Names:	YOL056W
ORF Names:	O1236

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Could be non-functional.
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate.
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.
Miscellaneous	Present with 3730 molecules/cell in log phase SD medium. Ref.5
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Phosphoglycerate mutase 3		PRO_0000179841
Sites
	Active site	14	1	Tele-phosphohistidine intermediate By similarity
	Active site	235	1	By similarity
	Site	70	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q12326 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 29C3FF3D28560914	FASTA	303	34,863
	10 20 30 40 50 60 MTVTDTFKLF ILRHGQSELN SENIFCGWID AQLTEKGKSQ ARHSAKLIKQ FCDSNNISLP 70 80 90 100 110 120 QIGYTSRLIR TQQTMDVILE ELGLKHTNYV ITTNTNIKEE LQDTRFEGSM PVLQTWRLNE 130 140 150 160 170 180 RHYGAWQGQR KPDILKEYGK EKYMYIRRDY NGKPPKVNLN LEMVQEENDQ GSSTGYDFKE 190 200 210 220 230 240 PNRHLKYGPE EKANERLPES ESLCEVVVRL KPFLNNVVLS TANKISQESC VIVGHGSSVR 250 260 270 280 290 300 SLLKVLEGIS DEDIKDVDIP NGIPLVIELD RDNYSFVRKF YLDPESAKVN AQMVRDEGFE KNP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of a 26 kb region on the left arm of yeast chromosome XV." Mannhaupt G., Vetter I., Schwarzlose C., Mitzel S., Feldmann H. Yeast 12:67-76(1996) [PubMed: 8789261] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 90843 / S288c / FY73.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XV." Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D. , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K. Nature 387:98-102(1997) [PubMed: 9169874] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Investigation of two yeast genes encoding putative isoenzymes of phosphoglycerate mutase." Heinisch J.J., Mueller S., Schlueter E., Jacoby J., Rodicio R. Yeast 14:203-213(1998) [PubMed: 9544241] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X91067 Genomic DNA. Translation: CAA62530.1. Z74798 Genomic DNA. Translation: CAA99064.1. BK006948 Genomic DNA. Translation: DAA10727.1.
PIR	S61723.
RefSeq	NP_014585.1. NM_001183311.1.
3D structure databases
ProteinModelPortal	Q12326.
SMR	Q12326. Positions 7-294.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4234N.
IntAct	Q12326. 5 interactions.
MINT	MINT-520340.
STRING	Q12326.
Proteomic databases
PeptideAtlas	Q12326.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YOL056W; YOL056W; YOL056W.
GeneID	854098.
KEGG	sce:YOL056W.
NMPDR	fig|4932.3.peg.5677.
Organism-specific databases
CYGD	YOL056w.
SGD	S000005417. GPM3.
Phylogenomic databases
eggNOG	fuNOG04978.
GeneTree	EFGT00070000008776.
HOGENOM	HBG658938.
OMA	NVARERW.
OrthoDB	EOG44F9K8.
Gene expression databases
ArrayExpress	Q12326.
Genevestigator	Q12326.
GermOnline	YOL056W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR013078. His_Pase_superF_clade-1. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1. [Graphical view]
KO	K01834.
PANTHER	PTHR11931. Phosphogly_mut1. 1 hit.
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. Pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	975767.

Entry information

Entry name

PMG3_YEAST

Accession

Primary (citable) accession number: Q12326
Secondary accession number(s): D6W211

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program